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公开(公告)号：EP3010537A2
公开(公告)日：2016-04-27
申请号：EP14734942.7
申请日：2014-06-17
CPC分类号： A61K39/13 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/545 , C12N7/00 , C12N2760/16051 , C12N2760/16134 , C12N2760/18051 , C12N2770/32051 , C12N2770/32351 , C12N2770/32634 , C12N2770/32651 , C12N2770/32663 , Y02A50/466
摘要： The present invention relates to a method for prevention and/or reduction of aggregation of viral components.
摘要翻译： 本发明涉及一种用于预防和/或减少病毒组分的聚合的方法。
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2.发明公开CELL LINES FOR VIRUS PRODUCTION AND METHODS OF USE 有权ZELLLINIEN ZUR VIRENHERSTELLUNG UND VERFAHREN ZUR VERWENDUNG
公开(公告)号：EP2954055A2
公开(公告)日：2015-12-16
申请号：EP14706395.2
申请日：2014-02-05
申请人： THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , The United States of America, as represented by The Secretary, Department of Health and Human Services , Thermo Fisher Scientific Inc.
IPC分类号： C12N15/113 , C12N5/00
CPC分类号： A61K39/13 , C12N7/00 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12N2770/32021 , C12N2770/32034 , C12N2770/32052 , C12N2770/32351 , C12N2770/32651
摘要： Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picomavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.
摘要翻译： 本文提供了工程细胞系。 在一些实施方案中，工程改造的细胞系的细胞具有改变的基因的表达和/或改变的miRNA表达，其中改变的表达导致病毒的产生增加或减少。 病毒是一种皮微病毒病毒，例如脊髓灰质炎病毒或肠病毒71.本文还提供了使用工程细胞产生病毒的方法，以及用于治疗患有或有风险患有病毒感染的受试者的方法。
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公开(公告)号：EP0357709A1
公开(公告)日：1990-03-14
申请号：EP89901874.0
申请日：1989-01-18
发明人： ROSER, Bruce, Joseph
CPC分类号： A61K39/245 , A61K39/12 , A61K39/13 , A61K39/23 , A61K2039/5252 , A61K2039/70 , C12N7/00 , C12N2750/14334 , C12N2760/16051 , C12N2760/16134 , C12N2770/32634 , C12N2770/32651 , C12N2795/10351 , Y02A50/466 , Y10S435/948
摘要： PCT No. PCT/GB89/00047 Sec. 371 Date Nov. 20, 1989 Sec. 102(e) Date Nov. 20, 1989 PCT Filed Jan. 18, 1989 PCT Pub. No. WO89/06542 PCT Pub. Date Jul. 27, 1989.A method of preserving live viruses comprises subjecting an aqueous system containing the virus to drying either in the frozen state or at ambient temperature, in the presence of trehalose.
摘要翻译： 所述的用于保存活病毒的方法涉及使含有病毒的含水系统在海藻糖存在下进行干燥操作，冷冻状态或室温。
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4.发明公开PROCESSES FOR PRODUCTION AND PURIFICATION OF NUCLEIC ACID-CONTAINING COMPOSITIONS 审中-公开生产和提纯含核酸组合物的方法
公开(公告)号：EP3307878A1
公开(公告)日：2018-04-18
申请号：EP16732426.8
申请日：2016-06-10
发明人： BROADT, Trevor, Lane , SHABAN, Samir, Hussein , XIE, Yueqing , ZHU, Jianwei, Sean , MITRA, George
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , B01D15/363 , C12N2770/32651
摘要： Described are improved processes for production and purification of nucleic acid-containing compositions, such as non-naturally occurring viruses, for example, recombinant polioviruses that can be employed as oncolytic agents. Some of the described improved processes relate to improved processes for producing viral DNA template. Also described are improved processes for chromatography purification of nucleic acid-containing compositions, in which the nucleic acid is quantified in chromatography fractions using a rapid detection method of the one or more nucleic acid sequences of the nucleic acid-containing composition, such as detection by real time RT-qPCR. In addition, improved processes for production and purification of oncolytic poliovirus, such as PVS-RIPO, are described. Compositions generated using these methods are also provided.
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公开(公告)号：EP1238057A2
公开(公告)日：2002-09-11
申请号：EP00985397.9
申请日：2000-12-04
申请人： Aventis Pasteur
发明人： GERDIL, Catherine
CPC分类号： C12N7/00 , C12N5/0037 , C12N5/0043 , C12N2500/50 , C12N2770/32651
摘要： The invention concerns a culture medium containing a polyvinylpyrrolidone as substitute for the serum of animal origin for producing animal or human adherent cells under stirring by increasing the cell proliferation or by decreasing cell death rate. Said medium is also suitable for producing viruses.
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公开(公告)号：EP1062324A2
公开(公告)日：2000-12-27
申请号：EP99907713.4
申请日：1999-03-15
申请人： Aventis Pasteur , Merial S.A.S.
CPC分类号： A61K39/13 , A61K39/12 , A61K39/205 , A61K2039/5252 , C12N5/0043 , C12N7/00 , C12N2500/76 , C12N2760/20134 , C12N2760/20151 , C12N2770/24134 , C12N2770/24151 , C12N2770/32634 , C12N2770/32651 , Y02A50/386 , Y02A50/39 , Y02A50/466
摘要： The invention concerns a medium for viral propagation and growth on cultivated cells, characterised in that it is free of human or animal proteins and it comprises proteins or glycoproteins extracted from potatoes or cucumber, having a mitogen potential and whereof the molecular weight ranges between 1000 and 200000 daltons and/or plant extract hydrolysates.
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公开(公告)号：EP3372685A2
公开(公告)日：2018-09-12
申请号：EP18164513.6
申请日：2014-02-05
申请人： University of Georgia Research Foundation, Inc. , The United States of America, as represented by The Secretary, Department of Health and Human Services , Thermo Fisher Scientific Inc.
IPC分类号： C12N15/113 , C12N5/00
CPC分类号： A61K39/13 , C12N7/00 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12N2770/32021 , C12N2770/32034 , C12N2770/32052 , C12N2770/32351 , C12N2770/32651
摘要： Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picornavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.
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公开(公告)号：EP0790836A4
公开(公告)日：2003-05-28
申请号：EP95941434
申请日：1995-11-30
申请人： DYNCORP , NAT INST HEALTH
IPC分类号： C12N5/00 , A61K39/12 , A61K39/125 , A61K39/13 , A61K39/15 , A61K39/29 , A61P31/12 , C12N7/00 , C12N7/04 , A61K39/145 , C12N5/06 , C12N7/02
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , C12N2720/12334 , C12N2720/12351 , C12N2740/10051 , C12N2740/14051 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251 , C12N2760/18534 , C12N2760/18551 , C12N2760/18634 , C12N2760/18651 , C12N2760/18734 , C12N2760/18751 , C12N2770/12034 , C12N2770/12051 , C12N2770/32334 , C12N2770/32351 , C12N2770/32434 , C12N2770/32451 , C12N2770/32634 , C12N2770/32651
摘要： A novel African Green Monkey Kidney (AGMK) cell line is taught as well as a method for the preparation thereof. The cell line which is free of viable adventitious microbial agents is useful as a substrate for viruses and for the preparation of viral vaccines.
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公开(公告)号：EP0790836A1
公开(公告)日：1997-08-27
申请号：EP95941434.0
申请日：1995-11-30
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , C12N2720/12334 , C12N2720/12351 , C12N2740/10051 , C12N2740/14051 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251 , C12N2760/18534 , C12N2760/18551 , C12N2760/18634 , C12N2760/18651 , C12N2760/18734 , C12N2760/18751 , C12N2770/12034 , C12N2770/12051 , C12N2770/32334 , C12N2770/32351 , C12N2770/32434 , C12N2770/32451 , C12N2770/32634 , C12N2770/32651 , Y02A50/466
摘要： A novel African Green Monkey Kidney (AGMK) cell line is taught as well as a method for the preparation thereof. The cell line which is free of viable adventitious microbial agents is useful as a substrate for viruses and for the preparation of viral vaccines.
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公开(公告)号：EP0357709B1
公开(公告)日：1993-09-29
申请号：EP89901874.1
申请日：1989-01-18
发明人： ROSER, Bruce, Joseph
CPC分类号： A61K39/245 , A61K39/12 , A61K39/13 , A61K39/23 , A61K2039/5252 , A61K2039/70 , C12N7/00 , C12N2750/14334 , C12N2760/16051 , C12N2760/16134 , C12N2770/32634 , C12N2770/32651 , C12N2795/10351 , Y02A50/466 , Y10S435/948
摘要： PCT No. PCT/GB89/00047 Sec. 371 Date Nov. 20, 1989 Sec. 102(e) Date Nov. 20, 1989 PCT Filed Jan. 18, 1989 PCT Pub. No. WO89/06542 PCT Pub. Date Jul. 27, 1989.A method of preserving live viruses comprises subjecting an aqueous system containing the virus to drying either in the frozen state or at ambient temperature, in the presence of trehalose.
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