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    METHODS OF MANUFACTURING SUPERCONDUCTOR AND PHONONIC ELEMENTS
    6.
    发明公开
    METHODS OF MANUFACTURING SUPERCONDUCTOR AND PHONONIC ELEMENTS 审中-公开

    公开(公告)号：EP3403285A1

    公开(公告)日：2018-11-21

    申请号：EP17700512.1

    申请日：2017-01-12

    申请人： Universiteit Leiden

    发明人： ALLAN, Milan

    IPC分类号： H01L39/12

    CPC分类号： H01L39/128

    摘要： There is provided methods of manufacturing a superconductor element and a method of manufacturing a phononic element. The method of manufacturing a superconductor element comprises the step of forming a periodic patterned structure in a material to alter an electronic structure in a primary layer (M) of the material to couple with the or each phonon of the primary layer (M) so as to induce superconductivity in the primary layer (M) or modify the superconductivity of the primary layer, and/or create or alter one or more phonons in a primary layer (M) of the material to couple with the electrons of the primary layer (M) so as to induce superconductivity in the primary layer (M) or modify the superconductivity of the primary layer. The method of manufacturing a phononic element comprises the steps of: providing one of a primary layer (M) and a secondary layer (M2) of a material on the other of the primary layer (M) and secondary layer (M2) of the material; and forming a periodic patterned structure in the secondary layer (M2) to create or alter one or more phonons in the primary layer (M).

    Biomarkers associated with depression
    7.
    发明授权
    Biomarkers associated with depression 有权

    公开(公告)号：EP2491137B1

    公开(公告)日：2018-07-25

    申请号：EP10776560.4

    申请日：2010-10-21

    申请人： Universiteit Leiden

    发明人： KLOK, Melanie, Diane ,  DE RIJK, Rolandus, Hendrikus ,  DE KLOET, Edo, Ronald

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  G01N33/5008 ,  G01N2800/301 ,  G01N2800/304

    摘要： Provided herein is a method of assessing the susceptibility of a subject to, or aiding the diagnosis of, an anxiety disorder or depression, the method including determining whether the subject has a haplotype including rs3216799, rs6814934, rs7658048, rs2070950 and rs2070951 with respective alleles ‘+CT, ‘C’, ‘T’, ‘C’ and ‘C’. Also provided is a kit of parts or solid substrate for use in assessing the susceptibility of a subject to an anxiety disorder or depression, the kit including or the solid substrate having attached thereto one or more nucleic acid molecules that hybridize selectively to a genomic region encompassing any two or more SNPs selected from the group consisting of rs3216799, rs6814934, rs7658048, rs2070950 and rs2070951, and/or that hybridize selectively to a genomic region encompassing two or more polymorphic sites in linkage disequilibrium with any one or more SNPs selected from rs3216799, rs6814934, rs7658048, rs2070950 and rs2070951.

    GLYCOSYLATED METABOLITES
    8.
    发明公开
    GLYCOSYLATED METABOLITES 审中-公开
    糖基化代谢物

    公开(公告)号：EP3314009A2

    公开(公告)日：2018-05-02

    申请号：EP16751025.4

    申请日：2016-06-24

    申请人： Universiteit Leiden

    发明人： AERTS, Johannes Maria Franciscus Gerardus ,  OVERKLEEFT, Hermen Steven

    IPC分类号： C12Q1/48 ,  G01N33/92 ,  G01N33/68

    CPC分类号： G01N33/92 ,  C12Q1/48 ,  G01N33/6893 ,  G01N2560/00

    摘要： The invention provides means and methods for detecting a glycosylated metabolite in a sample comprising adding to the sample a compound comprising a labelled glycosyl group coupled via an O-glycosidic bond to an aglycon with a specific structural formula wherein the glycosyl group comprises at least one isotope and/or a side chain being a label for detection, and wherein the sample is screened for the presence of a glycosylated metabolite with the glycosyl group other than a glucosylceramide. The invention further provides a method of treating a disorder caused by accumulation of a glycosylated metabolite other than glucosylceramide in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a glucosylceramide synthase (GCS) inhibitor.

    SCREENING METHOD
    9.
    发明授权
    SCREENING METHOD 有权
    筛选方法

    公开(公告)号：EP2616484B1

    公开(公告)日：2017-10-25

    申请号：EP11766909.3

    申请日：2011-09-15

    申请人： Universiteit Leiden ,  Academisch Ziekenhuis Leiden Acting Under The Name Leiden University Medical Center

    发明人： VAN DE WATER, Bob ,  VRIELING, Harm

    IPC分类号： C07K14/47 ,  A01K67/027 ,  C12N15/85 ,  C12N5/00 ,  C12N15/62

    CPC分类号： C12Q1/6897 ,  A01K2207/12 ,  A01K2267/0393 ,  C07K14/4738 ,  C12N15/1086 ,  C12N15/85 ,  C12Q2600/142

    摘要： The invention provides a polynucleotide comprising a reporter sequence operatively linked to a regulatory element of a gene selected from Bscl2, Srxnl, Cbr3, Ephxl, Nope, Cdknla, Perp, Pltp, Cgrefl, Ltb4r1, Btg2, Gpx2, Ltb4r2, Ddit4l, Fosl1, and Egr1, which regulatory element stimulates expression of the reporter sequence in response to a genotoxic agent or to an oxidative stress-inducing agent. The invention also provides a method of detecting a genotoxic or oxidative stress-inducing agent comprising subjecting a cell containing the polynucleotide of the invention to a test agent; and assessing the expression of the reporter sequence. The invention provides a method of detecting a genotoxic or oxidative stress-inducing agent comprising subjecting one or more cells that comprise a reporter sequence operatively linked to a regulatory element of a gene, which regulatory element stimulates expression of the reporter sequence in response to a genotoxic agent or to an oxidative stress-inducing agent, to a test agent, and assessing the expression of the one or more reporter sequences; wherein at least one cell subjected to a test agent comprises a polynucleotide comprising a reporter sequence operatively linked to a regulatory element of the Bscl2 gene.