摘要:
The present teachings provide a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.
摘要:
There is provided herein, a texaphyrin-phospholipid conjugate, wherein the texaphyrin-phospholipid conjugate comprises a texaphyrin, texaphyrin derivative or texaphyrin analog covalently attached to a lipid side chain of a phospholipid.
摘要:
There is provided herein methods, compounds and methods for identifying compounds, for sensitizing a subject with cancer to a cancer therapy by inhibiting or down-regulating UROD.
摘要:
The application relates to a nanovesicle comprising a bilayer of at least 15 mol % porphyrin-phospholipid conjugate, wherein the conjugate comprises a porphyrin, porphyrin derivative or porphyrin analog covalently attached to the phospholipid side chain. The nanovesicle can be used for photothermal therapy, photoacoustic imaging, and fluorescence imaging. The application also discloses a method of preparing the said nanovesicle.
摘要:
A mask for use in respiratory monitoring and/or diagnostics, and method of use thereof, the mask comprising at least one transducer responsive to sound and/or airflow, and a support structure configured to rest on a subject's face and extending outwardly therefrom to support the transducer at a distance and orientation from the nose and mouth, thereby allowing breathing sound and/or airflow monitoring via the transducer.
摘要:
Disclosed herein is a functional electrical stimulation (FES) device and system. In one embodiment, sequential bipolar pulse stimulation may be provided to an area of a living body via one or more electrode leads applied to the area via a FES device comprising a current pulse generating circuit comprising output nodes for operative coupling to the one or more electrode leads, and configured for operative coupling to a voltage supply. The current pulse generating circuit generally comprises positive and negative stimulation paths drawing from the voltage supply to respectively apply positive and negative currents through the area via the one or more electrode leads. In one example, the stimulation paths comprise respective capacitive elements, a capacitance ratio of which dictating, at least in part, an amplitude ratio of the positive and negative currents, wherein periodic alternative activation of the stimulation paths provides the sequential bipolar pulse stimulation. In another example, each path comprises a respective charging element and a respective activation switch, wherein each respective charging element is charged by the voltage supply and discharged upon activation of the respective activation switch to generate positive and negative current pulses respectively, such that a pulse rise time of the positive and negative current pulses is predominantly dictated by a switching speed of each respective switch. Systems and uses for these devices, and FES in general, are also described.
摘要:
The present teachings provide a compound represented by structural formula (1-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.