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公开(公告)号：EP4121004A1
公开(公告)日：2023-01-25
申请号：EP21713019.4
申请日：2021-03-22
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2.发明公开
公开(公告)号：EP2655660A2
公开(公告)日：2013-10-30
申请号：EP11808822.8
申请日：2011-12-21
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The present invention relates to methods for improving the diagnosis of pancreatic and ampullary adenocarcinomas by making use of specific mi RNA biomarkers and/or mi RNA classifiers.
摘要翻译： 本发明涉及通过利用特定的mi RNA生物标志物和/或mi RNA分类器来改善胰腺和壶腹腺癌的诊断方法。
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公开(公告)号：EP2343366A1
公开(公告)日：2011-07-13
申请号：EP10186180.5
申请日：2002-10-04
申请人： Novartis AG , Université Victor Segalen Bordeaux 2 , Oregon Health and Science University , Technische Universität München , University of Heidelberg , Centre Hospitalier Regional Universitaire de Lille , MEDVET SCIENCE PTY. LTD.
发明人： Barthe, Christophe , Branford, Susan , Corbin, Amie , Druker, Brian Jay , Duyster, Justus , Hochhaus, Andreas , Hughes, Timothy , Kreil, Sebastian , Leguay, Thibaut , Mahon, Francois-Xavier , Marit, Gerald , Mueller, Martin , Peschel, Christian , Preudhomme, Claude , Roche Lestienne, Catherine , Rudzki, Zbigniew
CPC分类号： C12N9/1205
摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, lle333, Phe317, Met318, Met351, Glu355, Glu359, lle360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要翻译： 本发明涉及分离的多肽，其包含功能激酶结构域，所述功能激酶结构域包含天然人Abl激酶结构域的氨基酸序列或其基本上相似的序列，其中至少一个选自Met244，Leu248，Gly250，Glu252，Tyr253， Val256，Glu258，Phe311，Ile333，Phe317，Met318，Met351，Glu355，Glu359，Ile360，His361，Leu370，Asp381，Phe382，His396，Ser417，Glu459和Phe486被另一个氨基酸置换，所述突变的功能激酶结构域对 通过N- [4-甲基-3-（4-吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基甲基） - 苯甲酰胺抑制其酪氨酸激酶活性 涉及使用这样的多肽筛选抑制这些多肽的酪氨酸激酶活性的化合物，编码这些多肽的核酸分子，包含这些核酸分子的重组载体和宿主细胞，以及涉及这样的多肽 核酸分子 用于筛选抑制这些多肽的酪氨酸激酶活性的化合物。
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公开(公告)号：EP2343365A1
公开(公告)日：2011-07-13
申请号：EP10186114.4
申请日：2002-10-04
申请人： Novartis AG , Université Victor Segalen Bordeaux 2 , Oregon Health and Science University , Technische Universität München , University of Heidelberg , Centre Hospitalier Regional Universitaire de Lille , MEDVET SCIENCE PTY. LTD.
发明人： Barthe, Christophe , Branford, Susan , Corbin, Amie , Druker, Brian Jay , Duyster, Justus , Hochhaus, Andreas , Hughes, Timothy , Kreil, Sebastian , Leguay, Thibaut , Mahon, Francois-Xavier , Marit, Gerald , Mueller, Martin , Peschel, Christian , Preudhomme, Claude , Roche Lestienne, Catherine , Rudzki, Zbigniew
CPC分类号： C12N9/1205
摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-y(methyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要翻译： 本发明涉及分离的多肽，其包含功能激酶结构域，所述功能激酶结构域包含天然人Abl激酶结构域的氨基酸序列或其基本上相似的序列，其中至少一个选自Met244，Leu248，Gly250，Glu252，Tyr253， Val256，Glu258，Phe311，Ile313，Phe317，Met318，Met351，Glu355，Glu359，Ile360，His361，Leu370，Asp381，Phe382，His396，Ser417，Glu459和Phe486被另一个氨基酸置换，所述突变的功能激酶结构域对 通过N- [4-甲基-3-（4-吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基）（甲基） - 苯甲酰胺或其盐的用途，涉及这些多肽用于筛选抑制这些多肽的酪氨酸激酶活性的化合物，编码这些多肽的核酸分子，包含此类核酸分子的重组载体和宿主细胞以及用途 的这种核酸分子 用于筛选抑制这些多肽的酪氨酸激酶活性的化合物。
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公开(公告)号：EP2290056A3
公开(公告)日：2011-06-01
申请号：EP10174534.7
申请日：2002-10-04
申请人： Novartis AG , Centre Hospitalier Regional Universitaire de Lille , MEDVET SCIENCE PTY. LTD. , Oregon Health & Science University , Technische Universität München , University of Heidelberg , Université Victor Segalen Bordeaux 2
发明人： Barthe, Christophe , Branford, Susan , Corbin, Amie , Druker, Brian Jay , Duyster, Justus , Hochhaus, Andreas , Hughes, Timothy , Kreil, Sebastian , Leguay, Thibaut , Mahon, François-Xavier , Marit, Gérald , Müller, Martin , Peschel, Christian , Preudhomme, Claude , Roche Lestienne, Catherine , Rudzki, Zbigniew
CPC分类号： C12N9/1205
摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
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公开(公告)号：EP1732570A2
公开(公告)日：2006-12-20
申请号：EP05700503.5
申请日：2005-01-27
申请人： Vysoká skola chemicko-technologická v Praze , Ustav organické chemie a biochemie av cz , Ustav anorganické chemie ac cz , Department of virology, University of Heidelberg
发明人： KRÁL, Vladimir , CIGLER, Petr , KONVALINKA, Jan , KOZÍSEK, Milan , PREJDOVÁ, Jana , GRÜNER, Bohumir , PLESEK, Jaromir , LEPSÍK, Martin , POKORNÁ, Jana , KRÄUSSLICH, Hans-Georg , BODEM, Jochen
CPC分类号： C07F15/065 , A61K31/69
摘要： The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster, wherein the charge of each borane, carborane or metallacarborane cluster is 0, -1 or -2; the number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster can be present heteroatoms as nitrogen, phosphorus, silicon, germanium, tin and sulphur. Pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectivity and stability.
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7.发明公开MICRORNA FOR DIAGNOSIS OF PANCREATIC CANCER AND/OR PROGNOSIS OF PATIENTS WITH PANCREATIC CANCER BY BLOOD SAMPLES 审中-公开微RNA胰腺肿瘤中血样的诊断和/或病人预后的胰腺肿瘤
公开(公告)号：EP2804958A2
公开(公告)日：2014-11-26
申请号：EP13702885.8
申请日：2013-01-16
申请人： Herlev Hospital , Ruprecht-Karls University of Heidelberg , KRAEFTENS BEKAEMPELSE , Rigshospitalet RH
发明人： JOHANSEN, Julia Sidenius , SCHULTZ, Nicolai Aagaard , WERNER, Jens , JENSEN, Benny Vittrup , ANDERSEN, Klaus K.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to methods for improving the diagnosis and prognosis of patients with pancreatic carcinoma by making use of specific mi RNA biomarkers associated with pancreatic carcinoma that may be identified based on a blood sample from an individual.
摘要翻译： 本发明涉及一种用于通过利用与胰腺癌相关的miRNA特异性生物标志物的改善的患者胰腺癌诊断和预后可识别基于血液样品并，特别是全血，血清或血浆样品的方法，从 个人。
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公开(公告)号：EP2290056A2
公开(公告)日：2011-03-02
申请号：EP10174534.7
申请日：2002-10-04
申请人： Novartis AG , Centre Hospitalier Regional Universitaire de Lille , MEDVET SCIENCE PTY. LTD. , Oregon Health & Science University , Technische Universität München , University of Heidelberg , Université Victor Segalen Bordeaux 2
发明人： Barthe, Christophe , Branford, Susan , Corbin, Amie , Druker, Brian Jay , Duyster, Justus , Hochhaus, Andreas , Hughes, Timothy , Kreil, Sebastian , Leguay, Thibaut , Mahon, François-Xavier , Marit, Gérald , Müller, Martin , Peschel, Christian , Preudhomme, Claude , Roche Lestienne, Catherine , Rudzki, Zbigniew
CPC分类号： C12N9/1205
摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要翻译： 本发明涉及分离的多肽，其包含功能性激酶结构域，其包含天然人类Abl激酶结构域的氨基酸序列或其基本相似的序列，其中至少一种选自Met244，Leu248，Gly250，Glu252，Tyr253， Val256，Glu258，Phe311，Ile313，Phe317，Met318，Met351，Glu355，Glu359，Ile360，His361，Leu370，Asp381，Phe382，His396，Ser417，Glu459和Phe486被另一个氨基酸取代，所述突变的功能性激酶结构域对 通过N- [4-甲基-3-（4-吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基甲基） - 苯甲酰胺抑制其酪氨酸激酶活性 或其盐使用这样的多肽来筛选抑制这种多肽的酪氨酸激酶活性的化合物，编码这种多肽的核酸分子，重组载体和包含这种核酸分子的宿主细胞，以及使用这种 核酸分子 这些多肽的制备用于筛选抑制这些多肽的酪氨酸激酶活性的化合物。
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公开(公告)号：EP2017335B1
公开(公告)日：2010-12-01
申请号：EP08166771.9
申请日：2002-10-04
申请人： Novartis AG , Université Victor Segalen Bordeaux 2 , Oregon Health and Science University , Technische Universität München , University of Heidelberg , Centre Hospitalier Regional Universitaire de Lille , MEDVET SCIENCE PTY. LTD.
发明人： Barthe, Christophe , Branford, Susan , Corbin, Amie , Druker, Brian Jay , Duyster, Justus , Hochhaus, Andreas , Hughes, Timothy , Kreil, Sebastian , Leguay, Thibaut , Mahon, Francois-Xavier , Marit, Gerald , Mueller, Martin , Peschel, Christian , Preudhomme, Claude , Roche Lestienne, Catherine , Rudzki, Zbigniew
CPC分类号： C12N9/1205
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10.发明公开
公开(公告)号：EP3596112A2
公开(公告)日：2020-01-22
申请号：EP18811911.9
申请日：2018-03-16
发明人： LOCHMULLER, Hanns , MULLER, Oliver
IPC分类号： C07K14/47 , C12N15/864
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