公开(公告)号：EP2303908B1

公开(公告)日：2017-07-26

申请号：EP09772291.2

申请日：2009-06-10

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  Université Victor Segalen Bordeaux 2

发明人： BERTHELOT, Thomas ,  DELERIS, Gérard

IPC分类号： C07K1/10 ,  C07K7/64 ,  C12Q1/37 ,  G01N33/52 ,  G01N33/58

CPC分类号： C12Q1/37 ,  C07K7/64 ,  G01N2333/95 ,  G01N2333/96494

公开(公告)号：EP2640477B1

公开(公告)日：2014-09-03

申请号：EP11797104.4

申请日：2011-11-17

申请人： Université Victor Segalen Bordeaux 2 ,  Ohrensstein, Hervé

发明人： OHRENSSTEIN, Hervé ,  POISSON, Philippe

IPC分类号： A63B71/08

CPC分类号： A63B71/085

公开(公告)号：EP2303908A2

公开(公告)日：2011-04-06

申请号：EP09772291.2

申请日：2009-06-10

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  Université Victor Segalen Bordeaux 2

发明人： BERTHELOT, Thomas ,  DELERIS, Gérard

IPC分类号： C07K1/10 ,  C07K7/64 ,  C12Q1/37 ,  G01N33/52 ,  G01N33/58

CPC分类号： C12Q1/37 ,  C07K7/64 ,  G01N2333/95 ,  G01N2333/96494

摘要： The invention relates to a cyclic peptide comprising the following sequence: -S
1 -X
1 -S
2 -X
2 - wherein S
1 is a first target peptide sequence of a protease enzyme E
1 , S
2 is a second target peptide sequence of a protease enzyme E
2 , S
1 and S
2 can be the same or different, the first peptide sequence S
1 and the second peptide sequence S
2 comprising between 4 and 14 amino acids, E
1 and E
2 corresponding to the same protease enzyme or to two separate protease enzymes, X
1 is a probe carrying a fluorescent donor group, and X
2 is a probe carrying a fluorescent or non-fluorescent acceptor group. Said peptides can be used in determining the activity of protease enzymes.

摘要翻译： 本发明涉及环肽包含以下序列： - S 1-X1-X2-S2 S1 worin是蛋白酶酶E1的第一靶肽序列，S2是蛋白酶酶E2，S1的第二靶肽序列和 S2可能是相同的或不同的，所述第一肽序列S1和所述第二肽序列S2包括4至14个氨基酸，E1和E2可能对应于同一蛋白酶或两种不同的蛋白酶，X 1是携带荧光探针 供体基团和X 2是带有荧光或非荧光受体基团的探针。 合成肽的以判定蛋白酶的酶的活性的应用。

公开(公告)号：EP2233135A1

公开(公告)日：2010-09-29

申请号：EP09015563.1

申请日：2008-10-16

申请人： Université Victor Segalen Bordeaux 2

发明人： Léauté-Labréze, Christine ,  Dumasde la Roche, Éric ,  Taieb, Alain ,  Thambo, Jean-Benoit

IPC分类号： A61K31/00 ,  A61K31/138 ,  A61K31/18 ,  A61K31/222 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/4704 ,  A61K31/5377 ,  A61K31/36 ,  A61P35/00

CPC分类号： A61K31/138 ,  A61K31/00 ,  A61K31/18 ,  A61K31/222 ,  A61K31/36 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/4704 ,  A61K31/5377

摘要： The present invention relates the use of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas, for example of infantile hemangiomas. The beta blocker may be a non-selective beta-blocker, for example propranolol. The present invention provides an alternative to the known compounds, e.g. corticosteroïds, interferon or vincristine, generally used for the treatment of hemangiomas.

摘要翻译： 本发明涉及用于治疗血管瘤，对于婴幼儿血管瘤的实施例的药物中的制造中的用途的β受体阻滞剂。 β阻滞剂可以是一种非选择性β-阻断剂，普萘洛尔对于实施例。 对本发明的替代提供对已知的化合物，例如 皮质类固醇，干扰素或长春新碱，用于血管瘤的治疗基因的反弹。

公开(公告)号：EP2080028A1

公开(公告)日：2009-07-22

申请号：EP07848315.3

申请日：2007-10-03

申请人： ABAG ,  Université Victor Segalen Bordeaux 2

发明人： CYNCYNATUS, Camille ,  NUYTTENS, Hélène

IPC分类号： G01N33/569 ,  G01N33/68 ,  C12Q1/68

CPC分类号： G01N33/56933 ,  G01N2469/20

摘要： The invention relates to the use of the 7F4 protein, having polypeptide sequence SEQ ID No 2, or of fragments or variants of said protein, or the use of the sequences encoding said proteins, in the field of the in vitro diagnosis of a Mycoplasma pneumoniae infection.

公开(公告)号：EP2017335A1

公开(公告)日：2009-01-21

申请号：EP08166771.9

申请日：2002-10-04

申请人： NOVARTIS AG ,  Université Victor Segalen Bordeaux 2 ,  Oregon Health and Science University ,  Technische Universität München ,  University of Heidelberg ,  Centre Hospitalier Regional Universitaire de Lille ,  MEDVET SCIENCE PTY. LTD.

发明人： Barthe, Christophe ,  Branford, Susan ,  Corbin, Amie ,  Druker, Brian Jay ,  Duyster, Justus ,  Hochhaus, Andreas ,  Hughes, Timothy ,  Kreil, Sebastian ,  Leguay, Thibaut ,  Mahon, Francois-Xavier ,  Marit, Gerald ,  Mueller, Martin ,  Peschel, Christian ,  Preudhomme, Claude ,  Roche Lestienne, Catherine ,  Rudzki, Zbigniew

IPC分类号： C12N9/12 ,  C12N15/00 ,  C12N5/00 ,  G01N33/50

CPC分类号： C12N9/1205

摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-yl m ethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

摘要翻译： 本发明涉及分离的多肽，其包含功能性激酶结构域，其包含天然人类Abl激酶结构域的氨基酸序列或其基本相似的序列，其中至少一种选自Met244，Leu248，Gly250，Glu252，Tyr253， Val256，Glu258，Phe311，Ile313，Phe317，Met318，Met351，Glu355，Glu359，Ile360，His361，Leu370，Asp381，Phe382，His396，Ser417，Glu459和Phe486被另一个氨基酸取代，所述突变的功能性激酶结构域对 通过N- [4-甲基-3-（4-吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基m乙基）对其酪氨酸激酶活性的抑制， 苯甲酰胺或其盐，使用这种多肽来筛选抑制这些多肽的酪氨酸激酶活性的化合物，编码这种多肽的核酸分子，重组载体和包含该核酸分子的宿主细胞，以及使用 的这种核酸痣 制备此类多肽的细胞用于筛选抑制这些多肽的酪氨酸激酶活性的化合物。

公开(公告)号：EP1646724B1

公开(公告)日：2009-01-07

申请号：EP04767758.8

申请日：2004-07-22

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Université Victor Segalen Bordeaux 2

发明人： DI RAGO, Jean-Paul ,  BONNEFOY, Nathalie ,  DUVEZIN-CAUBET, Stéphane

IPC分类号： C12P19/34 ,  C12R1/865 ,  C12N15/81 ,  C12N15/67

CPC分类号： C12R1/865 ,  C12P19/34

摘要： The invention relates to an industrial method for producing an interest heterologous RNA and to a system for carrying out said production method consisting (1) in transforming mitochondrions of yeast cells free of mitochondrial RNA with a mitochondrial transcription vector comprising at least one copy of the DNA encoding said interest heterologous RNA which are controlled by regulatory element(s) of the mitochondrial transcription and a reporter gene thereof or a fragment of said reporter gene, 2) identifying yeast transformants by incorporating the interest DNA into the mitochondrions thereof, (3) culturing the yeast mitochondrial transformants selected at the stage (2), (4) isolating the mitochondrions from the yeast mitochondrial transformants obtainable at stages (3) and in extracting and purifying the interest heterologous RNA from said mitochondrions.

公开(公告)号：EP1646724A2

公开(公告)日：2006-04-19

申请号：EP04767758.8

申请日：2004-07-22

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Université Victor Segalen Bordeaux 2

发明人： DI RAGO, Jean-Paul ,  BONNEFOY, Nathalie ,  DUVEZIN-CAUBET, Stéphane

IPC分类号： C12P19/34 ,  C12R1/865 ,  C12N15/81 ,  C12N15/67

CPC分类号： C12R1/865 ,  C12P19/34

摘要： The invention relates to an industrial method for producing an interest heterologous RNA and to a system for carrying out said production method consisting (1) in transforming mitochondrions of yeast cells free of mitochondrial RNA with a mitochondrial transcription vector comprising at least one copy of the DNA encoding said interest heterologous RNA which are controlled by regulatory element(s) of the mitochondrial transcription and a reporter gene thereof or a fragment of said reporter gene, 2) identifying yeast transformants by incorporating the interest DNA into the mitochondrions thereof, (3) culturing the yeast mitochondrial transformants selected at the stage (2), (4) isolating the mitochondrions from the yeast mitochondrial transformants obtainable at stages (3) and in extracting and purifying the interest heterologous RNA from said mitochondrions.

公开(公告)号：EP2640477A1

公开(公告)日：2013-09-25

申请号：EP11797104.4

申请日：2011-11-17

申请人： Université Victor Segalen Bordeaux 2 ,  Ohrensstein, Hervé

发明人： OHRENSSTEIN, Hervé ,  POISSON, Philippe

IPC分类号： A63B71/08

CPC分类号： A63B71/085

摘要： The invention relates to a mouthguard able to be shaped in the mouth, comprising an adaptable structure consisting of an adaptable material, and a skeleton, at least partially covered by the adaptable structure, consisting of a non-adaptable material. Said mouthguard also comprises a removable pallet consisting of a non-adaptable material and comprising a first region intended to butt against the skeleton, said region of the pallet being dimensioned such that, during the adaptation phase of the mouthguard, the combined presence of said pallet and of said skeleton ensures both ventilation space and the presence of sufficient material at the incisor-canine area.

公开(公告)号：EP2343367A1

公开(公告)日：2011-07-13

申请号：EP10186259.7

申请日：2002-10-04

申请人： Novartis AG ,  Université Victor Segalen Bordeaux 2 ,  Oregon Health and Science University ,  Technische Universität München ,  University of Heidelberg ,  Centre Hospitalier Regional Universitaire de Lille ,  MEDVET SCIENCE PTY. LTD.

发明人： Barthe, Christophe ,  Branford, Susan ,  Corbin, Amie ,  Druker, Brian Jay ,  Duyster, Justus ,  Hochhaus, Andreas ,  Hughes, Timothy ,  Kreil, Sebastian ,  Leguay, Thibaut ,  Mahon, Francois-Xavier ,  Marit, Gerald ,  Mueller, Martin ,  Peschel, Christian ,  Preudhomme, Claude ,  Roche Lestienne, Catherine ,  Rudzki, Zbigniew

IPC分类号： C12N9/12 ,  C12N15/00 ,  C12N5/00 ,  G01N33/50

CPC分类号： C12N9/1205

摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

摘要翻译： 本发明涉及分离的多肽，其包含功能性激酶结构域，其包含天然人类Abl激酶结构域的氨基酸序列或其基本相似的序列，其中至少一种选自Met244，Leu248，Gly250，Glu252，Tyr253， Val256，Glu258，Phe311，Ile313，Phe317，Met318，Met351，Glu355，Glu359，Ile360，His361，Leu370，Asp381，Phe382，His396，Ser417，Glu459和Phe486被另一个氨基酸取代，所述突变的功能性激酶结构域对 通过N- [4-甲基-3-（4-吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基甲基） - 苯甲酰胺抑制其酪氨酸激酶活性 或其盐使用这样的多肽来筛选抑制这种多肽的酪氨酸激酶活性的化合物，编码这种多肽的核酸分子，重组载体和包含这种核酸分子的宿主细胞，以及使用这种 核酸分子 这些多肽的制备用于筛选抑制这些多肽的酪氨酸激酶活性的化合物。