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1.发明授权
公开(公告)号：EP2079683B1
公开(公告)日：2015-01-21
申请号：EP07853752.9
申请日：2007-10-03
申请人： Virobay, Inc.
发明人： LINK, John O. , MOSSMAN, Craig J. , LIU, Jie , WOO, Soon Hyung
IPC分类号： C07C255/46 , A61K31/275 , A61P19/02 , A61P9/10
CPC分类号： C07C255/46
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2.发明授权HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 有权HALOGENALKYLHALTIGE化合物作为半胱氨酸蛋白酶抑制剂
公开(公告)号：EP2361243B9
公开(公告)日：2014-06-11
申请号：EP09826761.0
申请日：2009-11-12
申请人： Virobay, Inc.
发明人： HART, Barry , GREEN, Michael , SETTI, Eduardo , ROEPEL, Michael
IPC分类号： C07C237/04 , C07C255/46 , C07C317/48 , C07C323/60 , C07D213/32 , A61K31/277 , A61P11/06 , A61P19/02
CPC分类号： C07C317/48 , C07C237/04 , C07C255/46 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/32
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公开(公告)号：EP2215076A2
公开(公告)日：2010-08-11
申请号：EP08841879.3
申请日：2008-10-22
申请人： Virobay, Inc.
IPC分类号： C07D401/12 , C07D401/02 , C07D241/02
CPC分类号： C07D403/12
摘要： The present invention is directed to compounds that have the dual property of acting as cathepsin S inhibitors and of inhibiting HCV replication. Such compounds are therefore useful in treating disease states that include hepatitis C, Alzheimer's disease, and autoimmune disorders. The present invention is also directed to pharmaceutical compositions containing these compounds, and processes for preparing the compounds.
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4.发明授权Composition comprising an alpha ketoamide compound as cysteine protease inhibitor 有权包含α-酮酰胺化合物作为半胱氨酸蛋白酶抑制剂的组合物
公开(公告)号：EP2511257B1
公开(公告)日：2015-06-17
申请号：EP12174457.7
申请日：2006-03-17
申请人： Virobay, Inc.
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00 , A61K31/00 , C07D213/32 , C07C317/48
CPC分类号： C07C317/48 , C07C2601/02 , C07D213/32
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公开(公告)号：EP1866277B1
公开(公告)日：2014-06-25
申请号：EP06739439.5
申请日：2006-03-22
申请人： Virobay, Inc.
发明人： MOSSMAN, Craig, J.
IPC分类号： C07C233/00 , C07D211/30 , C07D211/82 , C07D261/06 , A61K31/16 , A61K31/42 , A61K31/44 , A61K31/47
CPC分类号： C07C317/46 , C07C2601/02 , C07C2601/04 , C07D213/32 , C07D213/70 , C07D261/08
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公开(公告)号：EP2237793A4
公开(公告)日：2013-07-31
申请号：EP09709414
申请日：2009-02-05
申请人： VIROBAY INC
发明人： HOLSINGER LESLIE
CPC分类号： A61K38/05
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7.发明授权HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 有权HALOGENALKYLHALTIGE化合物作为半胱氨酸蛋白酶抑制剂
公开(公告)号：EP2361243B1
公开(公告)日：2013-07-03
申请号：EP09826761.0
申请日：2009-11-12
申请人： Virobay, Inc.
发明人： HART, Barry , GREEN, Michael , SETTI, Eduardo , ROEPEL, Michael
IPC分类号： C07C237/04 , C07C255/46 , C07C317/48 , C07C323/60 , C07D213/32 , A61K31/277 , A61P11/06 , A61P19/02
CPC分类号： C07C317/48 , C07C237/04 , C07C255/46 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/32
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公开(公告)号：EP2511257A3
公开(公告)日：2013-01-09
申请号：EP12174457.7
申请日：2006-03-17
申请人： ViroBay, Inc.
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00 , A61K31/00 , C07D213/32 , C07C317/48
CPC分类号： C07C317/48 , C07C2601/02 , C07D213/32
摘要： The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins, B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
摘要翻译： 本发明涉及作为半胱氨酸蛋白酶抑制剂，特别是组织蛋白酶，B，K，L，F和S的化合物，因此可用于治疗由这些蛋白酶介导的疾病。 本发明涉及包含这些化合物的药物组合物及其制备方法。
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9.发明公开Alpha ketoamide compounds as cysteine protease inhibitors 有权Zusammensetzung enthaltend eine alpha-Ketoamid-Verbindung als半胱氨酸蛋白酶
公开(公告)号：EP2511257A2
公开(公告)日：2012-10-17
申请号：EP12174457.7
申请日：2006-03-17
申请人： ViroBay, Inc.
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00 , A61K31/00 , C07D213/32 , C07C317/48
CPC分类号： C07C317/48 , C07C2601/02 , C07D213/32
摘要： The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins, B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
摘要翻译： 本发明涉及作为半胱氨酸蛋白酶抑制剂，特别是组织蛋白酶，B，K，L，F和S的化合物，因此可用于治疗由这些蛋白酶介导的疾病。 本发明涉及包含这些化合物的药物组合物及其制备方法。
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10.发明公开CATHEPSIN INHIBITORS FOR TREATING MICROGLIA-MEDIATED NEURON LOSS IN THE CENTRAL NERVOUS SYSTEM 审中-公开CATHEPSINHEMMER在中枢神经系统在处理小胶质细胞介导的神经元丢失
公开(公告)号：EP2720692A2
公开(公告)日：2014-04-23
申请号：EP12800202.9
申请日：2012-06-18
申请人： Virobay, Inc.
发明人： BOOTH, Robert
IPC分类号： A61K31/277 , A61K31/4406 , A61P25/28 , A61P25/16 , A61P25/00
CPC分类号： A61K31/277 , A61K9/0019 , A61K9/08 , A61K9/2054 , A61K31/4406 , A61K47/12 , A61K47/26
摘要： The present invention concerns methods of using Cathepsin S inhibitors and compounds of Formula I that are inhibitors of cathepsin S in treating CNS disorders, diseases, and injuries, particularly neurodegenerative conditions. The present invention is directed to pharmaceutical compositions comprising these compounds for treating CNS disorders.
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