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    MORPHOLINOALKYL FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE
    2.
    发明公开
    MORPHOLINOALKYL FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE 审中-公开
    吗啉代富马酸酯化合物，药物组合物和使用方法

    公开(公告)号：EP2812319A1

    公开(公告)日：2014-12-17

    申请号：EP13704701.5

    申请日：2013-02-07

    申请人： XenoPort, Inc.

    发明人： CUNDY, Kenneth C. ,  MANTHATI, Suresh K ,  WUSTROW, David J.

    IPC分类号： C07D265/30 ,  A61K31/42 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00

    CPC分类号： C07D295/088 ,  C07D265/30

    摘要： Morpholinoalkyl fumarates, pharmaceutical compositions comprising the morpholinoalkyl fumarates, and methods of using morpholinoalkyl fumarates and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed.

    摘要翻译： 吗啉代烷基富马酸酯，包含富马酸吗啉代烷基酯的药物组合物，以及使用吗啉代烷基富马酸酯和药物组合物用于治疗神经变性，炎症和自身免疫性疾病，包括多发性硬化，牛皮癣， 帕金森病，亨廷顿舞蹈病和肌萎缩性侧索硬化。

    Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    6.
    发明公开
    Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof 审中-公开
    Synthese von Acyloxalkylcarbamat-Prodrugs und Zwischenprodukten davon

    公开(公告)号：EP2354120A1

    公开(公告)日：2011-08-10

    申请号：EP10010650

    申请日：2004-08-20

    申请人： XENOPORT INC

    发明人： GALLOP MARK A ,  YAO FENMEI ,  LUDWIKOW MARIA J ,  PHAN THU ,  PENG GE

    IPC分类号： C07C271/22 ,  A61K31/195 ,  C07D207/40 ,  C07D207/416 ,  C07D213/79 ,  C07D213/80 ,  C07D307/30 ,  C07D333/38 ,  C07D401/04

    CPC分类号： C07C271/22 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/79 ,  C07D307/30 ,  C07D333/38

    摘要： The present invention relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-tluorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The present invention also relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.

    摘要翻译： 本发明涉及（±）-4-氨基-3-（4-氟苯基）丁酸及其类似物的氨基氧基烷基氨基甲酸酯前药，其药物组合物，制备（±）-4-氨基-3-（ （±）-4-氨基-3-（4-氟苯基）丁酸及其类似物的前药的方法及其药物组合物用于治疗或预防常见疾病和/或障碍 如痉挛和/或酸反流疾病。 本发明还涉及适用于口服给药的（±）-4-氨基-3-（4-氟苯基）丁酸及其类似物的氨氧基烷基氨基甲酸酯前药及其缓释口服剂型。