公开(公告)号：EP3882338A1

公开(公告)日：2021-09-22

申请号：EP19876188.4

申请日：2019-10-25

申请人： Industry-Academic Cooperation Foundation, Yonsei University ,  University Industry Foundation, Yonsei University Wonju Campus

发明人： LEE, Hong Jai ,  KIM, Soo Ki ,  MOON, Jae Seung ,  SHIN, Bo Young ,  LEE, Sang Kyou ,  SHIN, Jin Su

IPC分类号： C12N5/071 ,  C12N7/00 ,  G01N33/50 ,  A01K67/027

摘要： The present invention relates to a method for producing virus-infected cell line or animal model. According to the present invention, for a human-derived lipid layer of a virus, a bile acid or a bile acid derivative allows the lipid layer to be replaced with a target animal model-derived lipid layer; and this makes it possible to produce a virus-infected animal model that can be effectively used clinically without limitation resulting from species specificity. Furthermore, in the method for producing a cell line, viruses are mixed with a bile acid or a bile acid derivative and the mixture is used to treat a culture medium of a cell line, so that a cell line infected with a very high level of the viruses can be obtained. In addition, use of the method for producing a cell line of the present invention allows viruses to infect cell lines derived from various species and organs without limitation resulting from the viral species specificity and the restraining force related to the viral specific tissue or organ tropism.

公开(公告)号：EP4043550A2

公开(公告)日：2022-08-17

申请号：EP20874292.4

申请日：2020-10-08

申请人： Genechem Inc. ,  University Industry Foundation, Yonsei University Wonju Campus ,  Industry-Academic Cooperation Foundation, Yonsei University

发明人： KIM, Sung Hoon ,  BAEK, Ah Reum ,  CHO, Sung Rae ,  WOO, Jin Suk ,  KIM, Li La ,  KIM, Dae Hee

IPC分类号： C12N5/00 ,  C12N5/0775 ,  C12N5/071 ,  A61K35/28 ,  A61K48/00

摘要： The present application pertains to a sialyloligosaccharide for augmenting the stemness of stem cells and a use thereof and provides a composition for augmenting stemness of stem cells, a method of culturing stem cells in a medium containing a sialyloligosaccharide, a method of augmenting stemness of stem cells, a stem cell with augmented stemness, obtained by the method, and a cell therapy composition including the stem cells as an active ingredient. The composition or the method according to one or more embodiments may suppress the aging of stem cells and may maintain and augment stemness.

公开(公告)号：EP4438051A1

公开(公告)日：2024-10-02

申请号：EP24159416.7

申请日：2024-02-23

申请人： Biome Inc. ,  Industry-Academic Cooperation Foundation, Yonsei University

发明人： YOON, Sang Sun ,  CHOI, Jun Yong ,  YOON, Mi Young ,  JEONG, Uk Jin

IPC分类号： A61K35/741 ,  A61K35/745 ,  A61P31/04 ,  A23L33/135 ,  A23K10/18

CPC分类号： A61K35/745 ,  A61K35/741 ,  A23L33/135 ,  A23K10/18 ,  A61P31/04

摘要： The present invention provides an antibacterial composition including two or more strains selected from the group consisting of Anaerostipes hadrus, Collinsella aerofaciens, Blautia wexlerae and Bifidobacterium longum strains that inhibit the activity of antibiotic-resistant bacteria.

公开(公告)号：EP4393383A1

公开(公告)日：2024-07-03

申请号：EP22870081.1

申请日：2022-05-11

申请人： University Industry Foundation, Yonsei University Wonju Campus

发明人： HWANG, Sung Oh ,  HAN, Ji Ho ,  YOON, Young Ro ,  CHA, Kyoung Chul

IPC分类号： A61B5/021 ,  A61B5/00 ,  A61H31/00

CPC分类号： A61B5/00 ,  A61H31/00 ,  A61B5/021

摘要： An apparatus for providing predicted blood pressure during cardiopulmonary resuscitation, and a method therefor are disclosed. An apparatus for providing predicted blood pressure during cardiopulmonary resuscitation, according to one embodiment of the present invention, comprises a blood pressure feedback device, which calculates index values from a chest compression waveform of a cardiopulmonary resuscitation feedback device and extracts predicted blood pressure on the basis of the calculated index values, so as to display or guide the predicted blood pressure, and thus an operator can be aware of a hemodynamic effect generated in a patent during cardiopulmonary resuscitation, so that the operator more effectively performs cardiopulmonary resuscitation.

公开(公告)号：EP4342583A1

公开(公告)日：2024-03-27

申请号：EP22804923.5

申请日：2022-05-13

申请人： Hanwha Solutions Corporation ,  Yonsei University, University-Industry Foundation(UIF).

发明人： ROH, Chiwoo ,  KIM, Hansung ,  KIM, Gil Ho ,  SONG, Kyu Ho

IPC分类号： B01J37/08 ,  B01J37/02 ,  B01J35/00 ,  B01J21/18 ,  C25B1/04 ,  C25B11/089 ,  C25B9/23

摘要： The present invention relates to: a method for preparing a reduction catalyst for water electrolysis using protective coating; a reduction electrode for alkaline water electrolysis comprising a reduction catalyst prepared thereby, and an alkaline water electrolysis system. The method for preparing a reduction catalyst for water electrolysis of the present invention applies a protective coating method and suppresses the growth of alloy particles in a subsequent high-temperature heat treatment step, and, thus, can prepare and provide a catalyst with a high alloying degree. As a result, a non-novel metal alloy catalyst prepared according to the method of the present invention has excellent catalytic characteristics by exhibiting hydrogen evolution reaction (HER) performance similar to that of platinum, which is a noble metal catalyst.

公开(公告)号：EP4332242A1

公开(公告)日：2024-03-06

申请号：EP22796218.0

申请日：2022-04-29

申请人： Industry-Academic Cooperation Foundation, Yonsei University

发明人： CHEONG, Jae-Ho ,  KIM, Jae-woo ,  YOON, Bo Kyung

IPC分类号： C12Q1/6886 ,  G01N33/574

摘要： A composition and method according to the present invention may be very effectively used to diagnose malignant gastric cancer and predict the prognosis of gastric cancer.

公开(公告)号：EP4299598A1

公开(公告)日：2024-01-03

申请号：EP22781612.1

申请日：2022-03-30

申请人： University-Industry Foundation(UIF), Yonsei University ,  Cellartgen Inc.

发明人： CHO, Seung Woo ,  CHOI, Soo Jeong ,  HWANG, Yong Soon ,  JEON, Ji Hoon

IPC分类号： C08B37/00 ,  C08L5/06 ,  C08J3/075 ,  A61K47/36 ,  A61K9/70 ,  A61K9/06 ,  A61P1/02

摘要： The present invention is intended to provide a hydrogel that utilizes the naturally occurring substance pectin to exhibit an equivalent or greater effect. Specifically, the present application is intended to provide a hydrogel or a patch which is stable, has strong adhesive strength, is advantageous for drug delivery, can be used for sustained treatment, has extremely low cytotoxicity, and is unlikely to induce an immune response, and thus can be used on various body parts, in particular the oral cavity. In addition, the present invention is intended to provide a hydrogel patch which employs a freezing method prior to crosslinking, and thus exhibits superior adhesion to patches employing a post-crosslinking freezing method.

公开(公告)号：EP4295811A2

公开(公告)日：2023-12-27

申请号：EP22756441.6

申请日：2022-02-14

申请人： Industry-Academic Cooperation Foundation Yonsei University

发明人： KIM, Jong Eun

IPC分类号： A61C19/05 ,  A61C7/00 ,  G16H50/50 ,  G16H30/00 ,  G16H20/30 ,  G16H10/60 ,  G06N3/08 ,  A61C9/00 ,  G06T7/00

摘要： An occlusal plane suggestion method according to an embodiment of the present invention comprises the steps in which: (a) an occlusal plane suggestion device receives at least one of first to fourth data for a person with normal occlusion and matches same to generate IVth image data; (b) the occlusal plane suggestion device analyzes the generated IVth image data to learn the relationship between a landmark, which is an anatomical singularity, and the occlusal plane of the person with normal occlusion; (c) the occlusal plane suggestion device receives at least one of first to fourth data about a patient; and (d) the occlusal plane suggestion device analyzes the received at least one of the first to fourth data about the patient on the basis of the learned relationship between the landmark and the normal occlusal plane to suggest and output an occlusal plane optimized for the patient.

公开(公告)号：EP4292592A1

公开(公告)日：2023-12-20

申请号：EP22753001.1

申请日：2022-02-10

申请人： Industry-Academic Cooperation Foundation, Yonsei University ,  Arontier Co., Ltd.

发明人： KU, Cheol Ryong ,  KANG, Chan Woo ,  WANG, Eun Kyung ,  OH, Ju Hun ,  HONG, Zhenyu ,  SOHN, Insuk ,  KANG, Un Ho

IPC分类号： A61K31/215 ,  A61P3/00 ,  A61P9/10 ,  A61P1/16 ,  A23L33/10

摘要： The present invention relates to a composition for regulating glucose that regulates the amount of glucose metabolized in the small intestine. According to the present invention, it is possible to improve glucose metabolism in the small intestine and to promote blood glucose excretion into feces, thus lowering blood glucose concentration, thereby preventing, alleviating or treating metabolic disease.

公开(公告)号：EP4286376A1

公开(公告)日：2023-12-06

申请号：EP22781692.3

申请日：2022-04-01

申请人： Therapex Co., Ltd. ,  Industry-Academic Cooperation Foundation, Yonsei University

发明人： SIM, Tae Bo ,  CHO, Byoung Chul ,  CHO, Han Na ,  SENGUPTA, Sandip ,  MALLA REDDY, Gannarapu ,  KIM, Young Hoon

IPC分类号： C07D401/12 ,  A61K31/506 ,  A61K31/5377 ,  A61P35/00 ,  C07D401/14 ,  C07D405/14

摘要： The present invention relates to a pharmaceutical composition for preventing and treating a cancer disease, including lung cancer, caused by abnormal cell growth containing a novel trisubstituted pyrimidine derivative with inhibitory activity against protein kinases, including EGFR, and a pharmaceutically acceptable salt thereof as active ingredients. The novel compound of the present invention has strong inhibitory activity against protein kinases. Particularly, the novel compound of the present invention has potent inhibitory effects against various drug-resistant EGFR mutants (including exon 19 deletion-T790M-C797S-EGFR, L858R-T790M-C797S-EGFR, exon 19 deletion-T790M-EGFR, and L858R-T790M-EGFR) and is useful as a prophylactic and therapeutic agent for cancer diseases caused by these EGFR mutants.