公开(公告)号：EP1644941B1

公开(公告)日：2011-11-23

申请号：EP04740828.1

申请日：2004-07-09

申请人： micromod Partikeltechnologie GmbH

发明人： TELLER, Joachim ,  WESTPHAL, Fritz ,  GRÜTTNER, Cordula

IPC分类号： H01F1/00 ,  H01F1/42 ,  H01F1/44

CPC分类号： A61K33/26 ,  A61K47/60 ,  A61K47/61 ,  A61K47/6849 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/186 ,  A61K49/1863 ,  A61K49/1875 ,  A61K51/1255 ,  B82Y5/00 ,  B82Y25/00 ,  H01F1/0054 ,  H01F1/445 ,  Y10S977/811 ,  Y10S977/83 ,  Y10S977/838

摘要： The invention relates to a method for producing magnetic nanoparticles which are made of metal oxide-polymer composites and are provided with an increased magnetic mobility, among other things, due the high metal oxide content and the morphological structure thereof. High-pressure homogenization has proven to be a reliable technique for producing the inventive magnetic nanoparticles. According to said technique, the components metal oxide and polymer are processed in a carrier medium water is used in most cases at pressures ranging from 500 bar to 1200 bar while using great shearing forces. High pressure homogenization creates a colloidally stable magnetic particle population having a diameter ranging below 200 nm while also resulting in the produced magnetic nanoparticles being provided with greater magnetic moments than the metal oxide used as an initial material at low magnetic field strengths. The inventive particles are particularly suitable for applications in the bioanalytical and diagnostic field, in bioseparation processes, and as a carrier material in high throughput screening.

公开(公告)号：EP1644941A1

公开(公告)日：2006-04-12

申请号：EP04740828.1

申请日：2004-07-09

申请人： micromod Partikeltechnologie GmbH

发明人： TELLER, Joachim ,  WESTPHAL, Fritz ,  GRÜTTNER, Cordula

IPC分类号： H01F1/00 ,  H01F1/42 ,  H01F1/44

CPC分类号： A61K33/26 ,  A61K47/60 ,  A61K47/61 ,  A61K47/6849 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/186 ,  A61K49/1863 ,  A61K49/1875 ,  A61K51/1255 ,  B82Y5/00 ,  B82Y25/00 ,  H01F1/0054 ,  H01F1/445 ,  Y10S977/811 ,  Y10S977/83 ,  Y10S977/838

摘要： The invention relates to a method for producing magnetic nanoparticles which are made of metal oxide-polymer composites and are provided with an increased magnetic mobility, among other things, due the high metal oxide content and the morphological structure thereof. High-pressure homogenization has proven to be a reliable technique for producing the inventive magnetic nanoparticles. According to said technique, the components metal oxide and polymer are processed in a carrier medium water is used in most cases at pressures ranging from 500 bar to 1200 bar while using great shearing forces. High pressure homogenization creates a colloidally stable magnetic particle population having a diameter ranging below 200 nm while also resulting in the produced magnetic nanoparticles being provided with greater magnetic moments than the metal oxide used as an initial material at low magnetic field strengths. The inventive particles are particularly suitable for applications in the bioanalytical and diagnostic field, in bioseparation processes, and as a carrier material in high throughput screening.

公开(公告)号：EP1036763B1

公开(公告)日：2001-12-05

申请号：EP99102661.8

申请日：1999-02-12

申请人： micromod Partikeltechnologie GmbH

发明人： Teller, Joachim Dr.rer.nat.habil. ,  Grüttner, Cordula Dr.rer.nat. ,  Rudershausen, Sandra Dr.rer.nat. ,  Westphal, Fritz Dipl.-Phys.

IPC分类号： C01B33/12 ,  C09B63/00

CPC分类号： C09B63/00

公开(公告)号：EP1036763A1

公开(公告)日：2000-09-20

申请号：EP99102661.8

申请日：1999-02-12

申请人： micromod Partikeltechnologie GmbH

发明人： Teller, Joachim Dr.rer.nat.habil. ,  Grüttner, Cordula Dr.rer.nat. ,  Rudershausen, Sandra Dr.rer.nat. ,  Westphal, Fritz Dipl.-Phys.

IPC分类号： C01B33/12 ,  C09B63/00

CPC分类号： C09B63/00

摘要： Die Erfindung betrifft ein Verfahren zur Herstellung monodisperser Polykieselsäure-Partikel mit einstellbaren Durchmessern zwischen 0,05 µm und 10 µm, die eine homogene und hohe (Fluoreszenz)farbstoffdichte bzw. Farb-/Fluoreszenzintensität aufweisen. Diese Partikel sind weiterhin durch eine ausgeprägte Sphärizität, geringe Variationskoeffizienten in der Größenverteilung und eine geringe Porosität der Oberfläche charakterisiert. Sie werden erfindungsgemäß durch hydrolytische Copolykondensation zwischen Prekursoren, wie Tetraalkoxysilanen und terminal silylierten (Fluoreszenz)farbstoffen gewonnen. Die somit herstellbaren Polykieselsäure-Partikel sind oberflächenchemisch so ausgestattet, daß anwendungsspezifische funktionelle Gruppen, Sequenzen, oder makromolekulare Strukturen erzeugt werden können

摘要翻译： 单分散聚硅酸颗粒的制备通过在醇，铵和水的水解介质中同时或逐步地使用前体物质四烷氧基硅烷和末端硅烷化荧光染料（I）来进行。 单分散聚硅酸颗粒的制备包括式（I）的前体物质四烷氧基硅烷和末端硅烷化荧光染料在醇，铵和水的水解介质中的同时或逐步剂量。 R1-R3 =卤素，烷基，芳基，烷氧基或甲硅烷氧基; R4 = Q1（X）m（Y）nQ2; n，m = 0或1; Q1 =烷基或1-20元杂类似物; X =功能序列; Y =具有与Q2连接的链或环结构的双官能有机序列; 和Q2 =结构上能够结合Y或X的荧光团系统或颜色分子，或者如果m和n均为0，则与Q1结合。 包括以下独立权利要求：（1）单分散，球形聚硅酸，可调粒径为0.05-10微米，均匀且高荧光或色密度或强度。