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1.发明公开
公开(公告)号：EP1765348A2
公开(公告)日：2007-03-28
申请号：EP05814989.9
申请日：2005-06-17
发明人： STOERMER, Doris , DELLARIA, Joseph, F., Jr. , AMOS, David, T. , ZIMMERMANN, Bernhard, M. , DRESSEL, Luke, T. , BONK, Jason, D. , RADMER, Matthew, R.
IPC分类号： A61K31/4745
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
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公开(公告)号：EP2793960B1
公开(公告)日：2016-10-12
申请号：EP12823119.8
申请日：2012-12-20
CPC分类号： A61L15/58 , A61L15/225 , A61L15/26 , C08G18/4837 , C08G18/758 , C08G77/12 , C08G77/20 , C08K5/56 , C08L71/02 , C08L83/00 , C09J7/25 , C09J7/50 , C09J183/04 , C09J2467/006 , C09J2471/003 , C09J2471/006 , C09J2475/006 , C09J2483/00 , Y10T428/2809 , Y10T428/2843 , Y10T428/2852 , C08L83/04 , C08G18/10 , C08G18/282 , C08L75/04 , C08L67/00
摘要： Adhesive articles that include a substrate and a silicone adhesive are disclosed. The articles also include a polymer containing poly(propylene oxide) units and optionally poly(ethylene oxide) units and having a number average molecular weight of at least 1000 grams per mole. The polymer may either be incorporated into the substrate or may be used as a primer on the substrate. If the polymer includes poly(ethylene oxide) units, the copolymer typically has a weight ratio of poly(ethylene oxide) to poly(propylene oxide) of up to 3:1, or if the copolymer has a number average molecular weight of at least 10,000 grams per mole, the weight ratio of poly(ethylene oxide) to poly(propylene oxide) is up to 2:1. Methods of making the adhesive articles are also disclosed.
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公开(公告)号：EP2793960A1
公开(公告)日：2014-10-29
申请号：EP12823119.8
申请日：2012-12-20
CPC分类号： A61L15/58 , A61L15/225 , A61L15/26 , C08G18/4837 , C08G18/758 , C08G77/12 , C08G77/20 , C08K5/56 , C08L71/02 , C08L83/00 , C09J7/25 , C09J7/50 , C09J183/04 , C09J2467/006 , C09J2471/003 , C09J2471/006 , C09J2475/006 , C09J2483/00 , Y10T428/2809 , Y10T428/2843 , Y10T428/2852 , C08L83/04 , C08G18/10 , C08G18/282 , C08L75/04 , C08L67/00
摘要： Adhesive articles that include a substrate and a silicone adhesive are disclosed. The articles also include a polymer containing poly(propylene oxide) units and optionally poly(ethylene oxide) units and having a number average molecular weight of at least 1000 grams per mole. The polymer may either be incorporated into the substrate or may be used as a primer on the substrate. If the polymer includes poly(ethylene oxide) units, the copolymer typically has a weight ratio of poly(ethylene oxide) to poly(propylene oxide) of up to 3:1, or if the copolymer has a number average molecular weight of at least 10,000 grams per mole, the weight ratio of poly(ethylene oxide) to poly(propylene oxide) is up to 2:1. Methods of making the adhesive articles are also disclosed.
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4.发明公开
公开(公告)号：EP1682544A2
公开(公告)日：2006-07-26
申请号：EP04810969.8
申请日：2004-11-12
发明人： KSHIRSAGAR, Tushar, A. , LUNDQUIST, Gregory, D., Jr. , AMOS, David, T. , DELLARIA, Joseph, F., Jr. , ZIMMERMANN, Bernhard, M. , HEPPNER, Philip, D.
IPC分类号： C07D471/00 , A61K31/44
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo ring compounds (e.g., imidazoquinolines, 6, 7, 8, 9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with a hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
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公开(公告)号：EP3589713A1
公开(公告)日：2020-01-08
申请号：EP18760285.9
申请日：2018-02-13
发明人： LU, Yongshang , HAO, Encai , XIA, Jianhui , QIE, Lili , AMOS, David, T. , HO, Charlie, Chia-Tie , POLSKI, Lauren, A. , ROSS, Richard, B.
IPC分类号： C09J175/06 , C09J175/14 , C09J7/38 , B32B27/40 , B32B7/04
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6.发明授权
公开(公告)号：EP1765348B1
公开(公告)日：2016-08-03
申请号：EP05814989.9
申请日：2005-06-17
发明人： STOERMER, Doris , DELLARIA, Joseph, F., Jr. , AMOS, David, T. , ZIMMERMANN, Bernhard, M. , DRESSEL, Luke, T. , BONK, Jason, D. , RADMER, Matthew, R.
IPC分类号： C07D471/14 , A61K31/437
CPC分类号： C07D471/04 , C07D471/14
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公开(公告)号：EP2341885A2
公开(公告)日：2011-07-13
申请号：EP09792302.3
申请日：2009-09-08
IPC分类号： A61K6/02
CPC分类号： A61K6/0023
摘要： The invention provides an orthodontic composition, related methods and packaged articles that include a hardenable component, a hardener, and a heat-modified inorganic mineral filler. The composition displays improved hardened remnant cleanup compared with compositions using traditional hard mineral fillers, while maintaining acceptable handling, bond strength and mechanical properties. Bond strength enhancement is achieved by heat-modifying a soft mineral filler, a process by which water of hydration is eliminated from the microstructure of the mineral to form a non-hydrated phase. By using heat-modified mineral fillers that are soft relative to human enamel, the hardened orthodontic composition can be conveniently removed using a low-speed abrasive disk or other mild abrasion process that is safer and more comfortable for the patient. The composition is especially beneficial for use in bonding orthodontic appliances to teeth.
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公开(公告)号：EP1685129A2
公开(公告)日：2006-08-02
申请号：EP04810872.4
申请日：2004-11-12
发明人： KSHIRSAGAR, Tushar, A. , LUNDQUIST, Gregory, D., Jr. , AMOS, David, T. , DELLARIA, Joseph, F., Jr. , ZIMMERMANN, Bernhard, M. , HEPPNER, Philip, D.
IPC分类号： C07D471/02 , C07D471/06
CPC分类号： C07D471/04 , C07D471/14 , C07D519/00
摘要： Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译： 含有在2-位具有肟取代基的咪唑环化合物（例如咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并萘啶和咪唑并吡啶），含有这些化合物作为免疫调节剂的化合物，中间体和方法的药物组合物 ，用于在动物中诱导细胞因子生物合成以及用于治疗包括病毒和肿瘤疾病的疾病。
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