公开(公告)号：EP2041085A1

公开(公告)日：2009-04-01

申请号：EP07812375.9

申请日：2007-06-27

申请人： ABBOTT LABORATORIES

发明人： FAGHIH, Ramin ,  GFESSER, Gregory A. ,  LYNCH, Christopher L. ,  GOPALAKRISHNAN, Murali ,  GOPALAKRISHNAN, Sujatha ,  MALYSZ, John ,  GUBBINS, Earl J. ,  EL KOUHEN, Rachid ,  LI, Jinhe

IPC分类号： C07D207/34 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  A61K31/402 ,  A61P25/00

CPC分类号： C07D207/34 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10

摘要： The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP2173764A2

公开(公告)日：2010-04-14

申请号：EP08771975.3

申请日：2008-06-26

申请人： Abbott Laboratories

发明人： GOPALAKRISHNAN, Murali ,  LI, Jinhe ,  CASSAR, Steven C ,  MALYSZ, John ,  ANDERSON, David J ,  GUBBINS, Earl J ,  BERTRAND, Daniel C

IPC分类号： C07K14/435

CPC分类号： C07K14/723 ,  C07K14/70571 ,  G01N33/566 ,  G01N2500/04

摘要： The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.

公开(公告)号：EP2038278A2

公开(公告)日：2009-03-25

申请号：EP07812349.4

申请日：2007-06-27

申请人： ABBOTT LABORATORIES

发明人： FAGHIH, Ramin ,  GFESSER, Gregory A. ,  LYNCH, Christopher L. ,  GOPALAKRISHNAN, Murali ,  GOPALAKRISHNAN, Sujatha ,  MALYSZ, John ,  GUBBINS, Earl J. ,  EL KOUHEN, Rachid ,  LI, Jinhe ,  SARRIS, Kathy A. ,  MICHMERHUIZEN, Melissa J. ,  WANG, Ying

IPC分类号： C07D417/04 ,  C07D413/04 ,  C07D417/14 ,  A61K31/422 ,  A61K31/427

CPC分类号： C07D417/04 ,  C07D413/04 ,  C07D417/14

摘要： The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are regulated by the nicotinic acetylcholine receptors.