公开(公告)号：EP2018380B1

公开(公告)日：2011-10-19

申请号：EP07797473.1

申请日：2007-05-15

申请人： ABBOTT LABORATORIES

发明人： JI, Jianguo ,  LI, Tao ,  LYNCH, Christopher L. ,  GOPALAKRISHNAN, Murali

IPC分类号： C07D451/08 ,  C07D451/14 ,  C07D519/00 ,  A61K31/4375 ,  A61P25/00

CPC分类号： C07D451/08 ,  C07D451/14 ,  C07D519/00

摘要： The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives of formula (I), or a pharmaceutically acceptable salt, ester, amid, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N+-O-; R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1 is a 6-membered aryl or 6 membered heteroaryl ring; and Ar2 is a bicyclic heteroaryl; and Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar1 is Formula (II), then L is O or S. Compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP2038278A2

公开(公告)日：2009-03-25

申请号：EP07812349.4

申请日：2007-06-27

申请人： ABBOTT LABORATORIES

发明人： FAGHIH, Ramin ,  GFESSER, Gregory A. ,  LYNCH, Christopher L. ,  GOPALAKRISHNAN, Murali ,  GOPALAKRISHNAN, Sujatha ,  MALYSZ, John ,  GUBBINS, Earl J. ,  EL KOUHEN, Rachid ,  LI, Jinhe ,  SARRIS, Kathy A. ,  MICHMERHUIZEN, Melissa J. ,  WANG, Ying

IPC分类号： C07D417/04 ,  C07D413/04 ,  C07D417/14 ,  A61K31/422 ,  A61K31/427

CPC分类号： C07D417/04 ,  C07D413/04 ,  C07D417/14

摘要： The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are regulated by the nicotinic acetylcholine receptors.

公开(公告)号：EP2041085A1

公开(公告)日：2009-04-01

申请号：EP07812375.9

申请日：2007-06-27

申请人： ABBOTT LABORATORIES

发明人： FAGHIH, Ramin ,  GFESSER, Gregory A. ,  LYNCH, Christopher L. ,  GOPALAKRISHNAN, Murali ,  GOPALAKRISHNAN, Sujatha ,  MALYSZ, John ,  GUBBINS, Earl J. ,  EL KOUHEN, Rachid ,  LI, Jinhe

IPC分类号： C07D207/34 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  A61K31/402 ,  A61P25/00

CPC分类号： C07D207/34 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10

摘要： The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP2018380A2

公开(公告)日：2009-01-28

申请号：EP07797473.1

申请日：2007-05-15

申请人： ABBOTT LABORATORIES

发明人： JI, Jianguo ,  LI, Tao ,  LYNCH, Christopher L. ,  GOPALAKRISHNAN, Murali

IPC分类号： C07D451/08 ,  C07D451/14 ,  C07D519/00 ,  A61K31/4375 ,  A61P25/00

CPC分类号： C07D451/08 ,  C07D451/14 ,  C07D519/00

摘要： The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives of formula (I), or a pharmaceutically acceptable salt, ester, amid, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N+-O-; R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1 is a 6-membered aryl or 6 membered heteroaryl ring; and Ar2 is a bicyclic heteroaryl; and Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar1 is Formula (II), then L is O or S. Compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP1685119A1

公开(公告)日：2006-08-02

申请号：EP04810896.3

申请日：2004-11-12

申请人： ABBOTT LABORATORIES

发明人： BRUNCKO, Milan ,  DING, Hong ,  ELMORE, Steven ,  KUNZER, Aaron R. ,  LYNCH, Christopher L. ,  MCCLELLAN, William ,  PARK, Cheol-Min ,  PETROS, Andrew ,  SONG, Xiaohong ,  WANG, Xilu ,  TU, Noah ,  WENDT, Michael D.

IPC分类号： C07D295/14 ,  A61K31/635 ,  A61P35/00 ,  C07D413/12 ,  C07D403/12 ,  C07D211/44 ,  C07C311/51

CPC分类号： C07D277/74 ,  C04B35/632 ,  C07C323/25 ,  C07C2601/16 ,  C07D205/04 ,  C07D207/16 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D295/13 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D409/12 ,  C07D487/04 ,  C07D487/08

摘要： Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein family member.

摘要翻译： 公开了抑制抗凋亡蛋白家族成员的活性的N-酰基磺酰胺化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生一种或多种抗凋亡蛋白家族成员的表达。