公开(公告)号：EP1380842A3

公开(公告)日：2009-12-30

申请号：EP03021136.1

申请日：1993-03-24

申请人： ABBOTT LABORATORIES

发明人： Clark, Frederic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J.III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A ,  Merriam, Richard A. ,  Walker, Donny Ray ,  McDowell, Douglas D. ,  Rumbaugh, William A. ,  Clemens, John M.

IPC分类号： G01N35/02

CPC分类号： G01N35/0095 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00277 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

摘要： A test sample container assembly for loading a plurality of test samples onto a test sample carousel of an automated analytical system and an automated, continuous and random access analytical system containing such test sample container assembly and capable of simultaneously effecting multiple assays of a plurality of liquid samples are disclosed. The test sample container assembly comprises (i) a housing with two parallel curved sides, said sides having the same radius of curvature as the test sample carousel, (ii) a top shelf with at least two openings for receiving test sample containers, (iii) a bottom parallel to and spaced apart from the top shelf defining with the curved surfaces therebetween a cavity, and (iv) wherein said bottom portion and said curved surfaces define a cavity therebetween wherein the at least two openings provide a predefined vertical alignment and the test sample container openings are presented in a plane parallel with the plane of the assembly shelf.

公开(公告)号：EP1450163A3

公开(公告)日：2004-09-15

申请号：EP04010902.7

申请日：1993-03-24

申请人： ABBOTT LABORATORIES

发明人： Clark, Frederick L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J. III. ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W. ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A. ,  Rumbaugh, William ,  Winter, Gary E. ,  Hance, Robert B. ,  Stanton, Alyn K. ,  Oleksak, Carl M. ,  Watkins, William E. III. ,  Vickstrom, Richard L. ,  Cloonan, Kevin M. ,  Wohlford Robert A. ,  Hills, David B. Jr. ,  Schrier, Paul R.

IPC分类号： G01N35/02 ,  G01N35/10 ,  F04B53/00

CPC分类号： G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

摘要： A bubble flushing aspirating and dispensing syringe having precision and volumetric accuracy, particularly for use in an automated, continuous and random access analytical system, is disclosed. The syringe comprises a piston (124) within a bore (128), the bore having seal means at a first end and a closed end (130) at a second end, wherein the piston forms an annulus (138) with the bore wall and seal means, and is capable of reciprocating therein. Fluid inlet (134) and fluid outlet (136) means are in communication with the annulus (138) and bore, the fluid inlet and fluid outlet means being located between the seal means and the bore closed end. A fluid source is in communication with the inlet means and a fluid conduit is in communication with the outlet means and an open-ended release tip. A drive means is connected to the piston for reciprocating the piston within the bore. As a result, fluid from the inlet, when connected to a fluid supply, flows through the annulus (138) around the sides of the piston and out through the fluid outlet to the open-ended tip, thereby creating a cross-flow pattern in the annulus (138) around the piston as it reciprocates in the bore to flush bubbles through the outlet.

公开(公告)号：EP1450162A2

公开(公告)日：2004-08-25

申请号：EP04010903.5

申请日：1993-03-24

申请人： ABBOTT LABORATORIES

发明人： Clark, Frederick L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J. III. ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W. ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A. ,  Rumbaugh, William ,  Winter, Gary E. ,  Hance, Robert B. ,  Stanton, Alyn K. ,  Oleksak, Carl M. ,  Watkins, William E. III. ,  Vickstrom, Richard L. ,  Cloonan, Kevin M. ,  Wohlford Robert A. ,  Hills, David B. Jr. ,  Schrier, Paul R.

IPC分类号： G01N35/04

CPC分类号： G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

摘要： A cartridge feeder apparatus for automated diagnostic systems is disclosed. The apparatus comprises a cartridge hopper means for receiving, storing and feeding cartridges (68) to a cartridge orientation mechanism, the cartridge orientation mechanism comprised of two opposed engageable orientation means (239) for engaging and disengaging a cartridge at each end of the cartridge. The cartridge has a funnel opening at a first end and a generally flat bottom at a second end.

摘要翻译： 公开了一种用于自动诊断系统的盒式馈送装置。 该装置包括用于将盒（68）接收，存储和馈送到盒取向机构的盒式存储器装置，盒取向机构包括两个相对的可接合定位装置（239），用于在盒的每一端处接合和分离盒。 墨盒在第一端具有漏斗开口，在第二端具有大致平坦的底部。

公开(公告)号：EP1028320A3

公开(公告)日：2001-03-14

申请号：EP00108051.4

申请日：1994-09-22

申请人： ABBOTT LABORATORIES

发明人： Clark, Frederick L. ,  Clemens, John M. ,  Hance, Robert B. ,  Hendrick, Kendall B. ,  Tayi, Apparao ,  Kanewske, William J. III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  McDowell, Douglas D. ,  Merriam, Richard A. ,  Moore, Larry W. ,  Oleksak, Carl M. ,  Pennington, Charles D. ,  Raymoure, William J. ,  Rumbaugh, William D. ,  Schmidt, Linda S. ,  Schrier, Paul R. ,  Smith B., Jane ,  Spronk, Adrian M. ,  Walker, Edna S. ,  Vaught, James A. ,  Vickstrom Richard L. ,  Walker, Donny Ray ,  Watkins, William E. III ,  Winter, Gary E. ,  Wohlford, Robert A. ,  Clift, Gilbert ,  Cloonan, Kevin M. ,  Mitchell, James E. ,  Stanton, Alyn K. ,  Yost, David A. ,  Hills, David B.

IPC分类号： G01N35/02

CPC分类号： G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

摘要： The present invention relates to a method of operating an automated, continuous and random access analytical system capable of simultaneously effecting multiple assays in a plurality of liquid samples, comprising the following steps: introducing sample cups, reagent packs, and reaction vessels for performing said assays onto concentric carousels of a front end carousel, the reaction vessels being introduced to an outer carousel; identifying the reagent packs and sample cups; scheduling the assays; aligning the sample cups and reagent packs with a reaction vessel at a kitting station by rotating the respective carousels; kitting a unit dose disposable in a reaction vessel having multiple independent open chambers in accordance with the scheduled assay by transfer of the sample from the sample cup to a reaction vessel chamber and transfer of specific reagents to separate reaction vessel chambers from the reagent pack; transferring the kitted reaction vessel to a process carousel which is maintained under controlled environment conditions; pipetting the sample and various reagents into a reaction well of the reaction vessel, the amounts of reagent, sequencing of transfer and time spacing therebetween being predetermined by assay scheduling; incubating the pipetted sample and reagent mix; identifying and transferring the incubated mixture in the reaction well to one of at least two assay analytical stations; performing an analysis by reading the prepared reaction mixture and calibrating the reading; and recording the resulting assay reading analysis.

公开(公告)号：EP1537915A3

公开(公告)日：2006-05-24

申请号：EP05004222.5

申请日：1993-03-24

申请人： ABBOTT LABORATORIES

发明人： Clark, Federic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J. III. ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W. ,  Penningon, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A. ,  Rumbaugh, William ,  Winter, Gary E. ,  Hance, Robert B. ,  Stanton, Alyn K. ,  Oleksak, Carl M. ,  Watkins, William E. III ,  Vickstrom, Richard L. ,  Cloonan, Kevin M. ,  Wohlford, Robert A. ,  Hills, David B. Jr. ,  Schrier, Paul R.

IPC分类号： B01L3/00 ,  G01N35/02

CPC分类号： G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

摘要： A reaction vessel suitable for multiple assay utilization within an automated, continuous and random access analytical system which allows for kitting of sample and reagents and physical transfer of the kitted reaction vessel to a process carousel is disclosed. The reaction vessel comprises multiple wells of various volume capacities, the multiple wells having openings on the same plane and depths extending from said plane. The reaction vessel has at least one cuvette, which extends substantially below the multiple wells and has an opening on the same plane as the multiple wells. The reaction vessel further comprises a transfer projection on a well bottom portion of the well on a first end portion of the reaction vessel, the cuvette projecting downward from a second end portion of the reaction vessel.

公开(公告)号：EP1443329A3

公开(公告)日：2004-09-29

申请号：EP04010960.5

申请日：1994-09-22

申请人： Abbott Laboratories

发明人： Clark, Frederick L. ,  Clemens, John M. ,  Hance, Robert B. ,  Hendrick, Kendall B. ,  Tayi, Apparao ,  Kanewske, William J. III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  McDowell, Douglas D. ,  Merriam, Richard A. ,  Moore, Larry W. ,  Oleksak, Carl M. ,  Pennington, Charles D. ,  Raymoure, William J. ,  Rumbaugh, William D. ,  Schmidt, Linda S. ,  Schrier, Paul R. ,  Smith, Jane B. ,  Spronk, Adrian M. ,  Walker, Edna S. ,  Vaught, James A. ,  Vickstrom, Richard L. ,  Walker, Donny Ray ,  Watkins, William E. III ,  Winter, Gary E. ,  Wohlford, Robert A. ,  Clift, Gilbert ,  Cloonan, Kevin M. ,  Mitchell, James E. ,  Stanton, Alyn K. ,  Yost, David A. ,  Hills, David B.

IPC分类号： G01N35/02 ,  G01N33/53

CPC分类号： G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

摘要： The present invention relates to a method for simultaneously performing at least two assays, said assays comprising a plurality of activities, for a plurality of liquid samples on a continuous analytical system, said method comprising the steps of: combining an aliquot of a first liquid sample with at least one reagent in a first reaction container to form a first assay reaction mixture for said first liquid sample; combining an aliquot of a second liquid sample with at least one reagent in a second reaction container to form a second assay reaction mixture for said second liquid sample; incubating said first and said second assay reaction mixtures at least one time; performing activities associated with each assay other than said combining and said incubating on the first and second assay reaction mixtures to complete each assay, said other activities including analyzing the incubated assay reaction mixtures; and scheduling the steps of said combining, said incubating, and said performing activities other than said combining and said incubating associated with each of the assays according to a predetermined protocol, said protocol specifying: (a) what activities are to be performed for a given assay; (b) an order in which said activities of (a) are to be performed; (c) at least one incubation period between said activities of (a), said at least one incubation period comprising a nominal period of time for the performance of an incubating step between activities of (a) and a specified window of time for varying the duration of the nominal period between activities of (a) to optimize performance; (d) how said activities of (a) are to be performed; and (e) duration of said activities of (a).

公开(公告)号：EP1450163A2

公开(公告)日：2004-08-25

申请号：EP04010902.7

申请日：1993-03-24

申请人： ABBOTT LABORATORIES

发明人： Clark, Frederick L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J. III. ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W. ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A. ,  Rumbaugh, William ,  Winter, Gary E. ,  Hance, Robert B. ,  Stanton, Alyn K. ,  Oleksak, Carl M. ,  Watkins, William E. III. ,  Vickstrom, Richard L. ,  Cloonan, Kevin M. ,  Wohlford Robert A. ,  Hills, David B. Jr. ,  Schrier, Paul R.

IPC分类号： G01N35/10

CPC分类号： G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

摘要： A bubble flushing aspirating and dispensing syringe having precision and volumetric accuracy, particularly for use in an automated, continuous and random access analytical system, is disclosed. The syringe comprises a piston (124) within a bore (128), the bore having seal means at a first end and a closed end (130) at a second end, wherein the piston forms an annulus (138) with the bore wall and seal means, and is capable of reciprocating therein. Fluid inlet (134) and fluid outlet (136) means are in communication with the annulus (138) and bore, the fluid inlet and fluid outlet means being located between the seal means and the bore closed end. A fluid source is in communication with the inlet means and a fluid conduit is in communication with the outlet means and an open-ended release tip. A drive means is connected to the piston for reciprocating the piston within the bore. As a result, fluid from the inlet, when connected to a fluid supply, flows through the annulus (138) around the sides of the piston and out through the fluid outlet to the open-ended tip, thereby creating a cross-flow pattern in the annulus (138) around the piston as it reciprocates in the bore to flush bubbles through the outlet.

摘要翻译： 公开了一种具有精度和体积精度的气泡冲洗抽吸和分配注射器，特别用于自动化，连续和随机存取分析系统中。 注射器包括在孔（128）内的活塞（124），孔在第一端处具有密封装置，在第二端处具有封闭端（130），其中活塞与孔壁形成环（138），并且 密封装置，并且能够在其中往复运动。 流体入口（134）和流体出口（136）装置与环空（138）连通并且钻孔，流体入口和流体出口装置位于密封装置和孔封闭端之间。 流体源与入口装置连通，并且流体导管与出口装置和开放式释放尖端连通。 驱动装置连接到活塞，以使活塞在孔内往复运动。 结果，来自入口的流体当连接到流体源时流过环绕活塞侧面的环（138）并通过流体出口流出到开口端，由此产生横流模式 活塞周围的环（138），其在孔中往复运动，以通过出口冲洗气泡。

公开(公告)号：EP1380842A2

公开(公告)日：2004-01-14

申请号：EP03021136.1

申请日：1993-03-24

申请人： Abbott Laboratories

发明人： Clark, Frederic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J.III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A ,  Merriam, Richard A. ,  Walker, Donny Ray ,  McDowell, Douglas D. ,  Rumbaugh, William A. ,  Clemens, John M.

IPC分类号： G01N35/02

CPC分类号： G01N35/0095 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00277 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

摘要： A test sample container assembly for loading a plurality of test samples onto a test sample carousel of an automated analytical system and an automated, continuous and random access analytical system containing such test sample container assembly and capable of simultaneously effecting multiple assays of a plurality of liquid samples are disclosed. The test sample container assembly comprises (i) a housing with two parallel curved sides, said sides having the same radius of curvature as the test sample carousel, (ii) a top shelf with at least two openings for receiving test sample containers, (iii) a bottom parallel to and spaced apart from the top shelf defining with the curved surfaces therebetween a cavity, and (iv) wherein said bottom portion and said curved surfaces define a cavity therebetween wherein the at least two openings provide a predefined vertical alignment and the test sample container openings are presented in a plane parallel with the plane of the assembly shelf.

摘要翻译： 一种用于将多个测试样品加载到自动分析系统的测试样品转盘上的测试样品容器组件和包含这种测试样品容器组件并且能够同时进行多种液体的多种测定的自动化，连续和随机存取分析系统 样品被公开。 测试样品容器组件包括（i）具有两个平行弯曲侧面的壳体，所述侧部具有与测试样品转盘相同的曲率半径，（ii）具有用于接收测试样品容器的至少两个开口的顶架，（iii ）平行于所述顶架的间隔开的底部，其间具有空腔之间的弯曲表面，以及（iv）其中所述底部部分和所述弯曲表面在其间限定了空腔，其中所述至少两个开口提供预定垂直对准，并且 测试样品容器开口呈现在与组装架平面平行的平面内。

公开(公告)号：EP1028320A2

公开(公告)日：2000-08-16

申请号：EP00108051.4

申请日：1994-09-22

申请人： ABBOTT LABORATORIES

发明人： Clark, Frederick L. ,  Clemens, John M. ,  Hance, Robert B. ,  Hendrick, Kendall B. ,  Tayi, Apparao ,  Kanewske, William J. III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  McDowell, Douglas D. ,  Merriam, Richard A. ,  Moore, Larry W. ,  Oleksak, Carl M. ,  Pennington, Charles D. ,  Raymoure, William J. ,  Rumbaugh, William D. ,  Schmidt, Linda S. ,  Schrier, Paul R. ,  Smith B, Jane ,  Spronk, Adrian M. ,  Walker, Edna S. ,  Vaught, James A. ,  Vickstrom Richard L. ,  Walker, Donny Ray ,  Watkins, William E. III ,  Winter, Gary E. ,  Wohlford, Robert A. ,  Clift, Gilbert ,  Cloonan, Kevin M. ,  Mitchell, James E. ,  Stanton, Alyn K. ,  Yost, David A. ,  Hills, David B.

IPC分类号： G01N35/02

CPC分类号： G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

摘要： The present invention relates to a method of operating an automated, continuous and random access analytical system capable of simultaneously effecting multiple assays in a plurality of liquid samples, comprising the following steps: introducing sample cups, reagent packs, and reaction vessels for performing said assays onto concentric carousels of a front end carousel, the reaction vessels being introduced to an outer carousel; identifying the reagent packs and sample cups; scheduling the assays; aligning the sample cups and reagent packs with a reaction vessel at a kitting station by rotating the respective carousels; kitting a unit dose disposable in a reaction vessel having multiple independent open chambers in accordance with the scheduled assay by transfer of the sample from the sample cup to a reaction vessel chamber and transfer of specific reagents to separate reaction vessel chambers from the reagent pack; transferring the kitted reaction vessel to a process carousel which is maintained under controlled environment conditions; pipetting the sample and various reagents into a reaction well of the reaction vessel, the amounts of reagent, sequencing of transfer and time spacing therebetween being predetermined by assay scheduling; incubating the pipetted sample and reagent mix; identifying and transferring the incubated mixture in the reaction well to one of at least two assay analytical stations; performing an analysis by reading the prepared reaction mixture and calibrating the reading; and recording the resulting assay reading analysis.

摘要翻译： 本发明涉及的方法在自动化的，连续的和随机存取的分析能够同时 - 影响多个测定在液体样品的复数，包括以下步骤系统中操作：将样品杯，试剂包，并且反应容器用于进行所述测定 到前端转盘的同心旋转木马，反应容器被引入到在传送带外; 标识试剂袋和样品杯; 调度所述测定法; 通过旋转respectivement转盘对准样品杯和试剂袋与在备料站的反应容器; 备料的单位剂量在具有雅舞蹈多个独立的开放腔室与从所述样品杯的样品转移至反应容器腔室和特定的试剂从试剂包单独的反应容器室的传送被调度的测定的反应容器中一次性; 被控制的环境条件下保持转移环成套的反应容器中的处理转盘所有; 吸移样本和各种试剂到反应容器中的反应孔试剂，量，转移和时间通过测定调度被预先确定之间的间隔有的测序; 孵育所述移液样品和试剂混合物; 在反应识别和传递环保温的混合物以及至少两个化验分析站中的一个; 通过读取制备的反应混合物中，并校准读出执行的分析; 并记录所得到的测定读数的分析。

公开(公告)号：EP1380843A3

公开(公告)日：2010-01-13

申请号：EP03021137.9

申请日：1993-03-24

申请人： ABBOTT LABORATORIES

发明人： Clark, Frederic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J.III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A ,  Merriam, Richard A. ,  Walker, Donny Ray ,  McDowell, Douglas D. ,  Rumbaugh, William A. ,  Clemens, John M.

IPC分类号： G01N35/02

CPC分类号： G01N35/0095 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00277 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

摘要： A liquid level sensing device for sensing the level of a liquid in a container and an automated, continuous and random access analytical system containing such liquid level sensing device and capable of simultaneously effecting multiple assays of a plurality of liquid samples are disclosed. The liquid level sensing device comprises: (a) means for producing an electrical sinusoidal signal; (b) means for evaluating the amount of signal as it propagates from a probe to a sense antenna; (c) circuit means for creating an electrical signal wherein said electrical signal changes when a probe contacts liquid; (d) signal processing means for enhancing the electrical signal and for degrading and suppressing signals not associated with the probe contacting said liquid; (e) decision circuit means for causing a basic digital output indicating either the presence or absence of liquid; and (f) means for utilizing the digital signal for controlling motion, and wherein said sensing device detects signal change and rate of signal change.