公开(公告)号：EP1814608A2

公开(公告)日：2007-08-08

申请号：EP05820209.4

申请日：2005-10-28

申请人： ABBOTT LABORATORIES

发明人： MOLLISON, Karl, W. ,  LECAPTAIN, Angela, M. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  TARCHA, Peter, J.

IPC分类号： A61L31/16 ,  A61L29/16 ,  A61K31/7048 ,  A61P9/10

CPC分类号： A61K31/7048 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  C07D498/18

摘要： A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stems, peripheral stems, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to, (I) This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti­thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drags, or combinations of these drugs.

公开(公告)号：EP1427457B1

公开(公告)日：2016-08-17

申请号：EP02770496.4

申请日：2002-09-10

申请人： ABBOTT LABORATORIES

发明人： MOLLISON, Karl, W. ,  LECAPTAIN, Angela, M. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  TARCHA, Peter, J.

IPC分类号： A61L31/16 ,  A61L27/54

CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/604 ,  A61L2300/606 ,  C07D498/18

公开(公告)号：EP0923735A1

公开(公告)日：1999-06-23

申请号：EP97926857.0

申请日：1997-06-03

申请人： Abbott Laboratories

发明人： POPE, Mark, R. ,  TARCHA, Peter, J. ,  MEES, David, R. ,  JOSEPH, Mary, K. ,  PRY, Terry, A. ,  PUTMAN, C., Brent ,  SUBOTICH, Daniel, T.

IPC分类号： G01N33

CPC分类号： G01N33/54393 ,  G01N33/54353 ,  Y10S435/962 ,  Y10S435/963 ,  Y10S436/81 ,  Y10S436/823

摘要： A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method involves both immobilizing a specific binding member on the surface of a solid phase material and degrading a steric stabilizer on the surface of that solid phase material. In the preferred embodiment, the method involves the immobilization of a specific binding member on the surface of the sterically stabilized solid phase material, with subsequent degradation of the steric stabilizer.

公开(公告)号：EP1578705A2

公开(公告)日：2005-09-28

申请号：EP02766269.1

申请日：2002-09-10

申请人： ABBOTT LABORATORIES

发明人： MOLLISON, Karl, W. ,  LECAPTAIN, Angela, M. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  TARCHA, Peter, J. ,  CHEN, Yen-Chih, J. ,  TONER, John, L.

IPC分类号： C07C1/00

CPC分类号： C07D498/18 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/606

摘要： A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

公开(公告)号：EP1427457A1

公开(公告)日：2004-06-16

申请号：EP02770496.4

申请日：2002-09-10

申请人： Abbott Laboratories

发明人： MOLLISON, Karl, W. ,  LECAPTAIN, Angela, M. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  TARCHA, Peter, J.

IPC分类号： A61L31/16 ,  A61L27/54

CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/604 ,  A61L2300/606 ,  C07D498/18

摘要： A medical device comprising a supporting structure having a coating on the surface thereof, the coating containing a therapeutic substance, such as, for example, a drug. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to,

公开(公告)号：EP1578705B1

公开(公告)日：2010-08-04

申请号：EP02766269.1

申请日：2002-09-10

申请人： ABBOTT LABORATORIES

发明人： MOLLISON, Karl, W. ,  LECAPTAIN, Angela, M. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  TARCHA, Peter, J. ,  CHEN, Yen-Chih, J. ,  TONER, John, L.

IPC分类号： C07C1/00

CPC分类号： C07D498/18 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/606

摘要： A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

公开(公告)号：EP0923735B1

公开(公告)日：2002-08-28

申请号：EP97926857.0

申请日：1997-06-03

申请人： Abbott Laboratories

发明人： POPE, Mark, R. ,  TARCHA, Peter, J. ,  MEES, David, R. ,  JOSEPH, Mary, K. ,  PRY, Terry, A. ,  PUTMAN, C., Brent ,  SUBOTICH, Daniel, T.

IPC分类号： G01N33/543 ,  G01N33/545 ,  G01N33/546

CPC分类号： G01N33/54393 ,  G01N33/54353 ,  Y10S435/962 ,  Y10S435/963 ,  Y10S436/81 ,  Y10S436/823

摘要： A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method involves both immobilizing a specific binding member on the surface of a solid phase material and degrading a steric stabilizer on the surface of that solid phase material. In the preferred embodiment, the method involves the immobilization of a specific binding member on the surface of the sterically stabilized solid phase material, with subsequent degradation of the steric stabilizer.