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公开(公告)号：EP1053239B1
公开(公告)日：2003-01-08
申请号：EP99906996.6
申请日：1999-02-12
发明人： COUGHLAN, Michael, J. , ELMORE, Steven, W. , KORT, Michael, E. , KYM, Philip, R. , MOORE, Jimmie, L. , PRATT, John, K. , WANG, Alan, X. , EDWARDS, James, P. , JONES, Todd, K.
IPC分类号： C07D491/04 , A61K31/44 , A61K31/505
CPC分类号： C07D491/04
摘要： Compounds having Formula (I), are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of inhibiting immune or autoimmune diseases in a mammal.
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公开(公告)号：EP1053239A1
公开(公告)日：2000-11-22
申请号：EP99906996.6
申请日：1999-02-12
发明人： COUGHLAN, Michael, J. , ELMORE, Steven, W. , KORT, Michael, E. , KYM, Philip, R. , MOORE, Jimmie, L. , PRATT, John, K. , WANG, Alan, X. , EDWARDS, James, P. , JONES, Todd, K.
IPC分类号： C07D491/04 , A61K31/44 , A61K31/505
CPC分类号： C07D491/04
摘要： Compounds having Formula (I), are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of inhibiting immune or autoimmune diseases in a mammal.
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3.发明公开DIBENZOPYRANS AS GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR TREATMENT OF DIABETES 有权DIBENZOPYRANE ALS糖皮质激素受体拮抗剂治疗糖尿病
公开(公告)号：EP1208095A1
公开(公告)日：2002-05-29
申请号：EP00959835.0
申请日：2000-09-01
申请人： Abbott Laboratories
IPC分类号： C07D311/80 , A61K31/352 , A61P3/10
CPC分类号： C07D311/80
摘要： The instant invention relates to compounds of formula (I) which are useful as antagonists of the glucocorticoid receptor and for treating diabetes in a mammal. In addition, any glucocorticoid receptor antagonist(s) is useful for the treatment of diabetes.
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公开(公告)号：EP1194429B1
公开(公告)日：2005-03-30
申请号：EP00941678.5
申请日：2000-06-23
申请人： Abbott Laboratories
发明人： CARROLL, William, A. , CHEN, Yiyuan , HOLLADAY, Mark, W. , KORT, Michael, E. , KYM, Philip, R. , SULLIVAN, James, P. , TANG, Rui , YI, Lin , ZHANG, Henry, Q.
IPC分类号： C07D495/04 , C07D215/36 , C07D221/04 , A61K31/44
CPC分类号： C07D221/04 , C07C45/00 , C07C45/298 , C07C45/41 , C07C45/63 , C07C45/71 , C07C205/44 , C07D215/36 , C07D495/04 , C07D495/14 , C07C47/565 , C07C47/55 , C07C49/753
摘要： Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
摘要翻译： 具有式（I）的化合物可用于治疗通过钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中打开钾通道的方法。
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公开(公告)号：EP1265839A1
公开(公告)日：2002-12-18
申请号：EP00993605.5
申请日：2000-12-06
申请人： KARO BIO AB , ABBOTT LABORATORIES
发明人： APELQVIST, Theresa , GILLNER, Mikael , GUSTAVSSON, Annika , HAGBERG, Lars , KOCH, Eva , NILSSON, Marita , PELCMAN, Benjamin , WU, Jinchang , KYM, Philip, R.
IPC分类号： C07C59/68 , C07C317/18 , C07C69/88 , C07C217/56 , C07C217/86 , C07C235/48 , C07C311/17 , C07C323/16 , C07C323/18 , C07D209/12 , C07D295/096 , C07D307/38 , A61K31/192 , A61K31/10 , A61K31/235 , A61K31/136 , A61K31/404 , A61K31/495 , A61K31/435 , A61K31/18
CPC分类号： C07D295/096 , C07C59/68 , C07C59/72 , C07C69/736 , C07C215/50 , C07C217/58 , C07C217/86 , C07C229/60 , C07C233/25 , C07C233/75 , C07C235/48 , C07C311/17 , C07C317/18 , C07C323/16 , C07C323/52 , C07C2601/02 , C07D209/12 , C07D295/13 , C07D307/38
摘要： This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy and in the regulation of metabolism, especially lowering blood glucose levels. The compounds referred to are compounds according to the formula (I).
摘要翻译： 本发明涉及作为肝选择性糖皮质激素受体拮抗剂的新型化合物，制备这些化合物的方法，以及在治疗和调节代谢中尤其降低血糖水平使用这些化合物的方法。 所谓的化合物是根据式（I）的化合物。
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公开(公告)号：EP1198456B1
公开(公告)日：2007-09-19
申请号：EP00955327.2
申请日：2000-08-02
申请人： ABBOTT LABORATORIES
发明人： ALTENBACH, Robert, J. , BAI, Hao , BRIONI, Jorge, D. , CARROLL, William, A. , GOPALAKRISHNAN, Murali , GREGG, Robert, J. , HOLLADAY, Mark, W. , HUANG, Peggy, P. , KINCAID, John, F. , KORT, Michael, E. , KYM, Philip, R. , LYNCH, John, K. , PEREZ-MEDRANO, Arturo , ZHANG, Henry, Q.
IPC分类号： C07D213/74 , C07C335/18 , C07C335/16 , C07C279/28 , C07C279/30 , C07D209/08 , C07D235/06 , C07D401/12 , C07D239/42 , C07D401/04 , C07D233/42 , C07D407/12 , C07C275/30 , C07D215/38 , A61K31/47 , A61K31/44 , A61K31/17 , A61K31/155
CPC分类号： C07D213/74 , A61K31/17 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07D209/08 , C07D215/38 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12
摘要： Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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7.发明授权DIBENZOPYRANS AS GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR TREATMENT OF DIABETES 有权DIBENZOPYRANE ALS糖皮质激素受体拮抗剂治疗糖尿病
公开(公告)号：EP1208095B1
公开(公告)日：2004-05-12
申请号：EP00959835.0
申请日：2000-09-01
申请人： Abbott Laboratories
IPC分类号： C07D311/80 , A61K31/352 , A61P3/10
CPC分类号： C07D311/80
摘要： The instant invention relates to compounds of formula (I) which are useful as antagonists of the glucocorticoid receptor and for treating diabetes in a mammal. In addition, any glucocorticoid receptor antagonist(s) is useful for the treatment of diabetes.
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公开(公告)号：EP1198456A2
公开(公告)日：2002-04-24
申请号：EP00955327.2
申请日：2000-08-02
申请人： Abbott Laboratories
发明人： ALTENBACH, Robert, J. , BAI, Hao , BRIONI, Jorge, D. , CARROLL, William, A. , GOPALAKRISHNAN, Murali , GREGG, Robert, J. , HOLLADAY, Mark, W. , HUANG, Peggy, P. , KINCAID, John, F. , KORT, Michael, E. , KYM, Philip, R. , LYNCH, John, K. , PEREZ-MEDRANO, Arturo , ZHANG, Henry, Q.
IPC分类号： C07D213/74
CPC分类号： C07D213/74 , A61K31/17 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07D209/08 , C07D215/38 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12
摘要： Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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公开(公告)号：EP1194429A1
公开(公告)日：2002-04-10
申请号：EP00941678.5
申请日：2000-06-23
申请人： Abbott Laboratories
发明人： CARROLL, William, A. , CHEN, Yiyuan , HOLLADAY, Mark, W. , KORT, Michael, E. , KYM, Philip, R. , SULLIVAN, James, P. , TANG, Rui , YI, Lin , ZHANG, Henry, Q.
IPC分类号： C07D495/04 , C07D215/36 , C07D221/04 , A61K31/44
CPC分类号： C07D221/04 , C07C45/00 , C07C45/298 , C07C45/41 , C07C45/63 , C07C45/71 , C07C205/44 , C07D215/36 , C07D495/04 , C07D495/14 , C07C47/565 , C07C47/55 , C07C49/753
摘要： Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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公开(公告)号：EP1131322A2
公开(公告)日：2001-09-12
申请号：EP99970991.8
申请日：1999-10-28
申请人： ABBOTT LABORATORIES
发明人： CARROLL, William, A. , AGRIOS, Konstantinos, A. , BASHA, Fatima, Z. , CHEN, Yiyuan , KORT, Michael, E. , KYM, Philip, R. , TANG, Rui , TURNER, Sean, C. , YI, Lin
IPC分类号： C07D471/00 , C07D491/04 , A61K31/435
CPC分类号： C07D471/04 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/14
摘要： Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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