Abstract:
Disclosed are a compound containing a diphenylmethane structure and a use thereof, belonging to the technical field of compound and polypeptide synthesis. The structure of the compound containing a diphenylmethane structure of the present invention is represented by General Formula (1). The compound containing a diphenylmethane structure of the present invention contains a hydroxyl group, an amino group, a substituted amino group, and an active group, and can be used as an amino acid or peptide C-terminal protection reagent. A peptide synthesis reaction using this protection carrier has a fast reaction speed and a high reagent utilization rate in a suitable solvent system; post-treatment is carried out by means of simple liquid-liquid extraction separation, i.e. effective purification can be carried out, and finally, a product with a high purity can be obtained; and during a synthesis process, the change in solubility is small and an operation process has a strong universality, and therefore, the present method can be developed into a universal production method.
Abstract:
The present invention provides a useful medicament for the treatment and/or prophylaxis of a disease associated with the enhancement of OPN production including cancer, which comprises a compound of formula: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , m, n, p, X, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.
Abstract:
Disclosed is an amide compound represented by the formula (1) below, which has excellent plant disease controlling activity.
In the formula, X 1 represents a fluorine atom or a methoxy group; X 2 represents a hydrogen atom, a halogen atom, a C 1 -C 4 alkyl group or the like; X 3 represents a halogen atom, a C 1 -C 4 alkyl group or the like; Z represents an oxygen atom or a sulfur atom; and A represents an A 1 -CR 11 R 12 R 13 group, an A 2 -Cy 1 group or an A 3 -Cy 2 group, wherein A 1 represents a CH 2 group or the like, A 2 represents a single bond, a CH 2 group or the like, A 3 represents a C 1 -C 3 haloalkyl group, a C 2 -C 4 alkenyl group or the like, Cy 1 represents a C 3 -C 6 cycloalkyl group substituted with a C 1 -C 6 alkoky group or the like, Cy 2 represents a C 3 -C 6 cycloalkyl group which may be substituted with a halogen atom or the like, R 11 and R 12 independently represent a C 1 -C 4 alkyl group, and R 13 represents a halogen atom, a hydroxyl group or the like.
Abstract:
Disclosed is an amide compound represented by the following formula (1). (1) (In the formula, X 1 represents a fluorine atom or a methoxy group; X 2 represents a hydrogen atom, a halogen atom, a C 1 -C 4 alkyl group or the like; represents an oxygen atom or a sulfur atom; and A represents an A 1 -CR 6 R 7 R 6 group, an A 2 -Cy 1 group or an A 3 -Cy 2 group, wherein A 1 represents a CH 2 group or the like, A 2 represents a single bond, a CH 2 group or the like, Cy 1 represents a C 3 -C 6 cycloalkyl group substituted with a C 1 -C 6 alkoxy group or the like, Cy 2 represents a C 3 -C 6 cycloalkyl group which may be substituted with at least one halogen atom or the like, R 6 and R 7 independently represent a C 1 -C 4 alkyl) group, and R 8 represents a halogen atom, a hydroxyl group or the like.) The amide compound has excellent plant disease controlling activity.
Abstract:
Disclosed is an amide compound represented by the formula (1) below, which has excellent plant disease controlling activity. (1) (In the formula, substituents represented by A, Z, X 1 , X 2 and X 3 and the like are as defined in the description.)
Abstract:
Amidocarboxylic acid derivatives represented by general formula (I), pharmacologically acceptable salts thereof, or pharmacologically acceptable esters thereof, wherein R1 represents a hydrogen atom or the like; R2 represents an alkylene group; R3 represents a hydrogen atom or the like; R4 represents a hydrogen atom or the like; X represents a substituted or unsubstituted aryl group or the like; Y represents an oxygen atom or the like; Z represents an alkylene group or the like; and W represents an alkyl group or the like. These compounds are useful as therapeutic and or prophylactic agents for diabetes, hyperlipemia, arterial sclerosis, hypertension and the like.