公开(公告)号：EP1198456B1

公开(公告)日：2007-09-19

申请号：EP00955327.2

申请日：2000-08-02

申请人： ABBOTT LABORATORIES

发明人： ALTENBACH, Robert, J. ,  BAI, Hao ,  BRIONI, Jorge, D. ,  CARROLL, William, A. ,  GOPALAKRISHNAN, Murali ,  GREGG, Robert, J. ,  HOLLADAY, Mark, W. ,  HUANG, Peggy, P. ,  KINCAID, John, F. ,  KORT, Michael, E. ,  KYM, Philip, R. ,  LYNCH, John, K. ,  PEREZ-MEDRANO, Arturo ,  ZHANG, Henry, Q.

IPC分类号： C07D213/74 ,  C07C335/18 ,  C07C335/16 ,  C07C279/28 ,  C07C279/30 ,  C07D209/08 ,  C07D235/06 ,  C07D401/12 ,  C07D239/42 ,  C07D401/04 ,  C07D233/42 ,  C07D407/12 ,  C07C275/30 ,  C07D215/38 ,  A61K31/47 ,  A61K31/44 ,  A61K31/17 ,  A61K31/155

CPC分类号： C07D213/74 ,  A61K31/17 ,  C07C233/78 ,  C07C233/83 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C279/28 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07D209/08 ,  C07D215/38 ,  C07D233/42 ,  C07D235/06 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12

摘要： Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP0934308B1

公开(公告)日：2004-08-11

申请号：EP97927830.6

申请日：1997-06-04

申请人： Abbott Laboratories

发明人： LIN, Nan-Horng ,  HE, Yun ,  HOLLADAY, Mark, W. ,  RYTHER, Keith ,  LI, Yihong ,  BAI, Hao

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  A61K31/44 ,  A61K31/445 ,  A61K31/465 ,  A61K31/505

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

公开(公告)号：EP1198456A2

公开(公告)日：2002-04-24

申请号：EP00955327.2

申请日：2000-08-02

申请人： Abbott Laboratories

发明人： ALTENBACH, Robert, J. ,  BAI, Hao ,  BRIONI, Jorge, D. ,  CARROLL, William, A. ,  GOPALAKRISHNAN, Murali ,  GREGG, Robert, J. ,  HOLLADAY, Mark, W. ,  HUANG, Peggy, P. ,  KINCAID, John, F. ,  KORT, Michael, E. ,  KYM, Philip, R. ,  LYNCH, John, K. ,  PEREZ-MEDRANO, Arturo ,  ZHANG, Henry, Q.

IPC分类号： C07D213/74

CPC分类号： C07D213/74 ,  A61K31/17 ,  C07C233/78 ,  C07C233/83 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C279/28 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07D209/08 ,  C07D215/38 ,  C07D233/42 ,  C07D235/06 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12

摘要： Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP0950057B1

公开(公告)日：2002-11-13

申请号：EP97952392.5

申请日：1997-12-10

申请人： Abbott Laboratories

发明人： HOLLADAY, Mark, W. ,  ARNERIC, Stephen, P. ,  BAI, Hao ,  DART, Michael, J. ,  LIN, Nan-Horng ,  LYNCH, John, K. ,  OR, Yat, Sun ,  RYTHER, Keith, B. ,  SULLIVAN, James, P. ,  WASICAK, James, T. ,  EHRLICH, Paul, P.

IPC分类号： C07D401/12 ,  A61K31/44 ,  C07D205/04

CPC分类号： C07D401/12 ,  A61K31/4427 ,  A61K31/485 ,  C07D205/04 ,  Y02P20/55 ,  A61K2300/00

摘要： The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：EP0950057A1

公开(公告)日：1999-10-20

申请号：EP97952392.0

申请日：1997-12-10

申请人： Abbott Laboratories

发明人： HOLLADAY, Mark, W. ,  ARNERIC, Stephen, P. ,  BAI, Hao ,  DART, Michael, J. ,  LIN, Nan-Horng ,  LYNCH, John, K. ,  OR, Yat, Sun ,  RYTHER, Keith, B. ,  SULLIVAN, James, P. ,  WASICAK, James, T. ,  EHRLICH, Paul, P.

IPC分类号： A61P25 ,  A61K31 ,  A61P29 ,  C07D205 ,  C07D401 ,  C07D405

CPC分类号： C07D401/12 ,  A61K31/4427 ,  A61K31/485 ,  C07D205/04 ,  Y02P20/55 ,  A61K2300/00

摘要： The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：EP1047690A1

公开(公告)日：2000-11-02

申请号：EP98964167.5

申请日：1998-12-18

申请人： Abbott Laboratories

发明人： HOLLADAY, Mark, W. ,  ABREO, Melwyn, A. ,  GUNN, David, E. ,  LIN, Nan-Horng ,  GARVEY, David, S. ,  RYTHER, Keith ,  LEBOLD, Suzanne, A. ,  ELLIOTT, Richard, L. ,  HE, Yun ,  WASIAK, James, T. ,  BAI, Hao ,  DART, Michael, J. ,  EHRLICH, Paul, P. ,  LI, Yihong ,  KINCAID, John, F. ,  SCHKERYANTZ, Jeffrey, M. ,  LYNCH, John, K.

IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D455/02 ,  A61K31/44 ,  A61K31/40 ,  A61K31/425 ,  A61K31/50 ,  A61K31/505 ,  A61K31/47

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04

摘要： Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.

公开(公告)号：EP0934308A1

公开(公告)日：1999-08-11

申请号：EP97927830.0

申请日：1997-06-04

申请人： Abbott Laboratories

发明人： LIN, Nan-Horng ,  HE, Yun ,  HOLLADAY, Mark, W. ,  RYTHER, Keith ,  LI, Yihong ,  BAI, Hao

IPC分类号： C07D401 ,  C07D405 ,  C07D409

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

摘要： Novel 3-pyridyloxymethyl heterocyclic ether compounds of formula (I) or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula (I) with the variables defined in the specification are also described.

公开(公告)号：EP1047690B1

公开(公告)日：2004-03-24

申请号：EP98964167.5

申请日：1998-12-18

申请人： Abbott Laboratories

发明人： HOLLADAY, Mark, W. ,  ABREO, Melwyn, A. ,  GUNN, David, E. ,  LIN, Nan-Horng ,  GARVEY, David, S. ,  RYTHER, Keith ,  LEBOLD, Suzanne, A. ,  ELLIOTT, Richard, L. ,  HE, Yun ,  WASIAK, James, T. ,  BAI, Hao ,  DART, Michael, J. ,  EHRLICH, Paul, P. ,  LI, Yihong ,  KINCAID, John, F. ,  SCHKERYANTZ, Jeffrey, M. ,  LYNCH, John, K.

IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D455/02 ,  A61K31/44 ,  A61K31/40 ,  A61K31/425 ,  A61K31/50 ,  A61K31/505 ,  A61K31/47

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04

摘要： Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.