公开(公告)号：EP1572900A4

公开(公告)日：2007-01-03

申请号：EP03705674

申请日：2003-01-06

申请人： ABGENIX INC

发明人： CORVALAN JOSE R F ,  JIA XIAO-CHI ,  FENG XIAO ,  YANG XIAO-DONG ,  CHEN FRANCINE ,  GAZIT GADI ,  WEBER RICHARD ,  BEZABEH BINYAM

IPC分类号： C07K16/22 ,  C12N15/09 ,  C12P21/08

CPC分类号： C07K16/22 ,  C07K2317/21 ,  C07K2317/56

摘要： The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions CDR's, specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

公开(公告)号：EP1613750A4

公开(公告)日：2008-06-25

申请号：EP04757910

申请日：2004-03-19

申请人： ABGENIX INC

发明人： LANDES GREGORY M ,  CHEN FRANCINE ,  BEZABEH BINYAM ,  FOLTZ IAN ,  TSE KAM FEI ,  JEFFERS MICHAEL ,  STARLING GARY ,  MEZES PETER ,  KHRAMTSOV NIKOLIA ,  MESRI MEHDI

IPC分类号： C12N15/12 ,  A61K39/395 ,  A61K51/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C07K16/28 ,  C07K16/46 ,  C12N5/06 ,  G01N33/53

CPC分类号： C07K16/2803 ,  A61K47/48446 ,  A61K47/48561 ,  A61K51/1039 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2809 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/50 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/574 ,  G01N2333/70503

摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

摘要翻译： 描述在本发明涉及指向抗原TIM-1抗体和抗体寻求的用途。 特别地，设置有引导至抗原TIM -1完全人单克隆抗体。 分离的多核苷酸序列编码，和氨基酸序列，其包含重链和轻链免疫球蛋白分子，特别是序列对应于通过FR4连续重和轻链序列跨越构架区（FR'S）和/或互补性决定区（CDR'S），具体地从FR1 或CDR1到CDR3，提供。 检验的杂交瘤或表达免疫球蛋白分子的其它细胞系和单克隆抗体因此提供。