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    HUMANIZED ANTIBODY AGAINST AMYLOID BETA
    2.
    发明授权
    HUMANIZED ANTIBODY AGAINST AMYLOID BETA 有权
    人源化抗AMYLOID BETA抗体

    公开(公告)号：EP2074145B1

    公开(公告)日：2017-08-16

    申请号：EP07867188.0

    申请日：2007-10-02

    申请人： AC Immune S.A. ,  Genentech, Inc.

    发明人： PFEIFER, Andrea ,  PIHLGREN, Maria ,  MUHS, Andreas ,  WATTS, Ryan

    IPC分类号： C07K16/18

    CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/6896

    摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of j3-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid- like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

    摘要翻译： 本发明涉及嵌合和人源化抗体以及用于治疗和诊断用于治疗与淀粉样蛋白如阿尔茨海默氏病有关的一组疾病和异常的淀粉样变性的方法和组合物。

    MONOCLONAL ANTI BETA AMYLOID ANTIBODY
    6.
    发明公开
    MONOCLONAL ANTI BETA AMYLOID ANTIBODY 有权
    单克隆抗β-淀粉样蛋白抗体

    公开(公告)号：EP2170953A1

    公开(公告)日：2010-04-07

    申请号：EP08768370.2

    申请日：2008-06-12

    申请人： AC Immune S.A. ,  Genentech, Inc.

    发明人： PFEIFER, Andrea ,  PIHLGREN, Maria ,  MUHS, Andreas ,  WATTS, Ryan

    IPC分类号： C07K16/18 ,  A61K39/395 ,  A61P25/28 ,  C12N5/20

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  A61K2039/6018 ,  A61K2039/6093 ,  C07K2317/56 ,  C07K2317/565

    摘要： The present application is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present application provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present application are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

    HUMANIZED ANTIBODY AGAINST AMYLOID BETA
    8.
    发明公开
    HUMANIZED ANTIBODY AGAINST AMYLOID BETA 审中-公开
    人源化抗AMYLOID BETA抗体

    公开(公告)号：EP3309172A1

    公开(公告)日：2018-04-18

    申请号：EP17190333.9

    申请日：2007-07-13

    申请人： AC Immune S.A. ,  GENENTECH, INC.

    发明人： PFEIFER, Andrea ,  PIHLGREN BOSCH, Maria ,  MUHS, Andreas ,  WATTS, Ryan

    IPC分类号： C07K16/18 ,  A61P25/28

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821 ,  G01N2800/56

    摘要： The invention provides an artificial hybrid antibody comprising two different heavy/light chain pairs and two different binding sites, or active fragment thereof, wherein a first heavy/light chain pair binds beta-amyloid. The invention also provides a composition comprising the artificial hybrid antibody or active fragment thereof, and the composition for use in a method of treating or alleviating one or more effects of amyloidosis. The invention further provides a cell comprising two different nucleic acid molecules encoding a humanized antibody or epitope-binding fragment thereof that binds to beta-amyloid and method of producing a humanized antibody or epitope-binding fragment thereof that binds to beta-amyloid.

    摘要翻译： 本发明提供了人造杂合抗体，其包含两个不同的重/轻链对和两个不同的结合位点或其活性片段，其中第一重/轻链对结合β-淀粉样蛋白。 本发明还提供了包含人造杂合抗体或其活性片段的组合物，以及用于治疗或减轻淀粉样变性的一种或多种影响的方法中的组合物。 本发明进一步提供了包含编码与β-淀粉样蛋白结合的人源化抗体或其表位结合片段的两种不同核酸分子的细胞以及产生结合β-淀粉样蛋白的人源化抗体或其表位结合片段的方法。