-
公开(公告)号：EP2906251B1
公开(公告)日：2017-09-27
申请号：EP13786186.0
申请日：2013-10-11
IPC分类号： A61K47/68 , A61P35/02 , C07K16/28 , C07K16/30 , A61K39/395 , A61K31/551
CPC分类号： A61K47/6803 , A61K31/551 , A61K31/5517 , A61K45/06 , A61K47/6801 , A61K47/6849 , A61K47/6867 , A61K2039/505 , C07K16/1063 , C07K16/2803 , C07K16/2851 , C07K2317/24 , C07K2317/40 , C07K2317/56 , C07K2317/73
摘要： Conjugates of an isolated humanized, anti-CD22 antibody with PBD dimers.
摘要翻译： 分离的人源化抗CD22抗体与PBD二聚体的偶联物。
-
公开(公告)号：EP3164418A1
公开(公告)日：2017-05-10
申请号：EP15718985.3
申请日：2015-04-15
IPC分类号： C07K16/30
CPC分类号： C07K16/3092 , A61K47/48569 , A61K47/6803 , A61K47/6855 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/72 , C07K2317/76 , C07K2317/92 , Y02P20/55
摘要： Humanized anti-Tn-MUC1 antibodies and conjugates thereof. Conjugates comprising pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker to the antibody are described.
摘要翻译： 人源化抗Tn-MUC1抗体及其缀合物。 描述了包含具有与抗体的接头形式的不稳定保护基的吡咯并苯并二氮杂（PBD）的缀合物。
-
公开(公告)号：EP3054983B1
公开(公告)日：2019-03-20
申请号：EP14787022.4
申请日：2014-10-10
-
公开(公告)号：EP2906253B1
公开(公告)日：2018-08-01
申请号：EP13795435.0
申请日：2013-10-11
CPC分类号： A61K31/5517 , A61K45/06 , A61K47/6803 , A61K47/6869 , C07K16/18
摘要： Conjugates of an antibody that binds to PSMA with PBD dimers.
-
公开(公告)号：EP2906250B1
公开(公告)日：2018-05-30
申请号：EP13785372.7
申请日：2013-10-11
IPC分类号： A61K47/68 , A61P35/00 , A61K31/551
CPC分类号： A61K31/551 , A61K45/06 , A61K47/6869 , C07K16/18 , C07K2317/24 , C07K2317/56
摘要： Conjugates of an antibody that binds to PSMA with PBD dimers.
-
公开(公告)号：EP3283122A1
公开(公告)日：2018-02-21
申请号：EP16716589.3
申请日：2016-04-15
CPC分类号： C07K16/2803 , A61K47/6803 , A61K47/6867 , A61P35/02 , C07D487/04 , C07K2317/24 , C07K2317/53 , Y02P20/55
摘要： Site-specific antibody-drug conjugates are described, in particular conjugates comprising pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antiobody moiety, allows for improved safety and efficacy of the ADC.
-
公开(公告)号：EP3054983A1
公开(公告)日：2016-08-17
申请号：EP14787022.4
申请日：2014-10-10
CPC分类号： A61K47/6803 , A61K45/06 , A61K47/6869 , C07K16/40 , C07K2317/24 , C07K2317/56
摘要： Conjugates of specific PBD dimers with an antibody that binds to PSMA, the antibody comprising a VH domain having the sequence according to any one of SEQ ID NOs. 1, 3, 5, 7, 8, 9, or 10, optionally further comprising a VL domain having the sequence 5 according to any one of SEQ ID NOs. 2, 4, 6, 11, 12, 13, 14, 15, 16, 17, or 18.
摘要翻译： 特定PBD二聚体与结合PSMA的抗体缀合，该抗体包含具有根据SEQ ID NO。 1,3,5,7,8,9或10，任选地进一步包含具有根据SEQ ID NOs.1中任一项的序列5的VL结构域。 2,4,6,11,12,13,14,15,16,17或18位。
-
公开(公告)号：EP3054985B1
公开(公告)日：2018-12-26
申请号：EP14787024.0
申请日：2014-10-10
CPC分类号： A61K47/6851 , A61K31/5517 , A61K45/06 , A61K47/54 , A61K47/6803 , A61K47/6849 , C07K16/30
摘要： Conjugates of specific PBD dimers with an antibody that that binds to CD19, the antibody comprising a VH domain having the sequence according to any one of SEQ ID NOs. 1, 2, 3, 4, 5 or 6, optionally further comprising a VL domain having the sequence according to any one of SEQ ID NOs. 7, 8, 9, 10, 11 or 12.
-
公开(公告)号：EP3283119A1
公开(公告)日：2018-02-21
申请号：EP16716584.4
申请日：2016-04-15
CPC分类号： A61K47/6803 , A61K39/44 , A61K47/6855 , A61K2039/505 , A61P35/00 , C07K16/32 , C07K2317/52 , C07K2317/94 , Y02P20/55
摘要： Site-specific anti-body-drug conjugates are described, in particular conjugates comprising an antibody, which binds HER2 and comprises an amino acid substitution of an interchain cysteine residue by an amino acid that is not cysteine, and pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antibody moiety, allows for improved safety and efficacy of the ADC.
-
公开(公告)号：EP3223854A1
公开(公告)日：2017-10-04
申请号：EP15801398.7
申请日：2015-11-25
CPC分类号： A61K31/5517 , A61K47/48384 , A61K47/48561 , A61K47/48715 , A61K47/6803 , A61K47/6849 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present disclosure relates to the use of antibody-drug conjugates (ADCs) comprising pyrrolobenzodiazepine (PBD) dimers and anti-CD25 antibodies for use in treating disorders characterized by the presence of CD25+ve cells.
摘要翻译： 本公开涉及包含吡咯并苯并二氮杂（PBD）二聚体和抗CD25抗体的抗体 - 药物缀合物（ADC）用于治疗以CD25 + ve细胞的存在为特征的病症的用途。
-
-
-
-
-
-
-
-
-
搜索结果
61 条记录 (耗时 0.034 秒)
