摘要:
A modified haemoglobin for use as an oxygen carrier in a blood substitute is prepared by covalently bonding haemoglobin or a haemoglobin derivative to a polyalkylene glycol, via an amide bond. A carboxyl group is first introduced onto the polyalkylene glycol, and is then reacted with an amino group of the haemoglobin or haemoglobin derivative to form the amide bond.
摘要:
Modified hemoglobins suitable for use as oxygen carriers for blood substitutes are disclosed. The hemoglobins, which may optionally be derivatives thereof, are combined with inulin and the resulting substance has characteristics which make it suitable for use as an oxygen carrier for a blood substitute, in particular its good residence time and its ability to act as a plasma expander.
摘要:
A modified haemoglobin for use as an oxygen carrier in a blood substitute is prepared by covalently bonding haemoglobin or a haemoglobin derivative to a polyalkylene glycol, via an amide bond. A carboxyl group is first introduced onto the polyalkylene glycol, and is then reacted with an amino group of the haemoglobin or haemoglobin derivative to form the amide bond.