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    Oxygen carrier
    2.
    发明公开
    Oxygen carrier 失效
    Sauerstoff-Träger。

    公开(公告)号：EP0067029A2

    公开(公告)日：1982-12-15

    申请号：EP82302826.1

    申请日：1982-06-02

    申请人： AJINOMOTO CO., INC.

    发明人： Iwashita, Yuji ,  Iwasaki, Keiji ,  Ajisaka, Katsumi

    IPC分类号： A61K37/14 ,  C08G65/32

    CPC分类号： C08G65/329 ,  A61K38/00 ,  A61K47/60 ,  C07K14/805 ,  C08G65/32 ,  Y10S530/815

    摘要： A modified haemoglobin for use as an oxygen carrier in a blood substitute is prepared by covalently bonding haemoglobin or a haemoglobin derivative to a polyalkylene glycol, via an amide bond. A carboxyl group is first introduced onto the polyalkylene glycol, and is then reacted with an amino group of the haemoglobin or haemoglobin derivative to form the amide bond.

    摘要翻译： 通过经由酰胺键将血红蛋白或血红蛋白衍生物共价键合到聚亚烷基二醇，制备用作血液替代物中的氧载体的修饰血红蛋白。 首先将羧基引入到聚亚烷基二醇上，然后与血红蛋白或血红蛋白衍生物的氨基反应形成酰胺键。

    Modified hemoglobins suitable for use as oxygen carriers for blood substitutes
    3.
    发明公开
    Modified hemoglobins suitable for use as oxygen carriers for blood substitutes 失效
    AlsSauerstoffträgerfürBlutersatzmittel verwendbare modifizierteHämoglobine。

    公开(公告)号：EP0043675A1

    公开(公告)日：1982-01-13

    申请号：EP81302858.6

    申请日：1981-06-25

    申请人： AJINOMOTO CO., INC.

    发明人： Ajisaka, Katsumi ,  Iwashita, Yuji

    IPC分类号： C07G7/00 ,  A61K37/14

    CPC分类号： C07K14/805 ,  A61K38/00 ,  A61K47/60

    摘要： Modified hemoglobins suitable for use as oxygen carriers for blood substitutes are disclosed. The hemoglobins, which may optionally be derivatives thereof, are combined with inulin and the resulting substance has characteristics which make it suitable for use as an oxygen carrier for a blood substitute, in particular its good residence time and its ability to act as a plasma expander.

    摘要翻译： 公开了适合用作血液代用品的氧载体的修饰血红蛋白。 可以任选地是其衍生物的血红蛋白与菊糖组合，所得物质具有使其适合用作血液替代物的氧载体的特性，特别是其良好的停留时间及其作为等离子体扩张器的能力 。

    Superoxide dismutase combined with a poly(alkylene oxide
    7.
    发明公开
    Superoxide dismutase combined with a poly(alkylene oxide 失效
    与聚（亚烷基氧化物）组合的超氧化物歧化酶

    公开(公告)号：EP0200467A3

    公开(公告)日：1988-02-24

    申请号：EP86303058

    申请日：1986-04-23

    申请人： AJINOMOTO CO., INC.

    发明人： Yabuki, Akira ,  Iwashita, Yuji

    IPC分类号： C12N09/02 ,  C12N09/96 ,  A61K37/50

    CPC分类号： C12N9/96 ,  A61K38/446 ,  A61K47/60 ,  C12N9/0089

    摘要： Superoxide dismutase is chemically modified with poly(alkylene oxide), the modified superoxide dismutase having a molecular structure in which both ends of a poly(alkylene oxide) molecule are attached to superoxide dismutase. The modified superoxide dismutase can be used to remove toxic substances derived from oxygen, from the blood circulation in a living body, and has a longer half life in the blood circulation as compared to superoxide dismutase which has not been modified.

    Superoxide dismutase combined with a poly(alkylene oxide)
    8.
    发明公开
    Superoxide dismutase combined with a poly(alkylene oxide) 失效
    联合超氧化物歧化酶一个聚（环氧烷）。

    公开(公告)号：EP0200467A2

    公开(公告)日：1986-11-05

    申请号：EP86303058.1

    申请日：1986-04-23

    申请人： AJINOMOTO CO., INC.

    发明人： Yabuki, Akira ,  Iwashita, Yuji

    IPC分类号： C12N9/02 ,  C12N9/96 ,  A61K37/50

    CPC分类号： C12N9/96 ,  A61K38/446 ,  A61K47/60 ,  C12N9/0089

    摘要： Superoxide dismutase is chemically modified with poly(alkylene oxide), the modified superoxide dismutase having a molecular structure in which both ends of a poly(alkylene oxide) molecule are attached to superoxide dismutase. The modified superoxide dismutase can be used to remove toxic substances derived from oxygen, from the blood circulation in a living body, and has a longer half life in the blood circulation as compared to superoxide dismutase which has not been modified.