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公开(公告)号:EP4417684A1
公开(公告)日:2024-08-21
申请号:EP22881009.9
申请日:2022-10-11
申请人: AJINOMOTO CO., INC.
IPC分类号: C12N1/21 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61P1/00 , A61P1/02 , A61P3/04 , A61P9/10 , A61P17/00 , A61P17/02 , A61P35/00 , C12N15/12 , C12P1/04 , C12P21/02
CPC分类号: A61K35/74 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61P1/00 , A61P1/02 , A61P3/04 , A61P9/10 , A61P17/00 , A61P17/02 , A61P35/00 , C07K14/435 , C12N15/74 , C12P1/04 , C12P21/02
摘要: Provided is a technology whereby a heterologous protein can be expressed in a bacterium which does not have an endogenous Tat system secretion machine. The present specification discloses a bacterium that is selected from the group consisting of bifidobacteria, lactococci, and staphylococci and has been modified to express a heterologous Tat protein. The bacterium has the ability to produce and secrete a heterologous protein.