公开(公告)号：EP1081159A4

公开(公告)日：2001-10-31

申请号：EP99921221

申请日：1999-05-20

申请人： AJINOMOTO KK

发明人： ONO KUNIO ,  TSUCHIYA SHIGEKATSU ,  EJIMA DAISUKE ,  ETO YUZURU

IPC分类号： A61K38/00 ,  C07K1/18 ,  C07K14/47 ,  C07K14/575 ,  C12P21/02

CPC分类号： C07K14/575 ,  A61K38/00

摘要： A process for producing human activin with a high purity which comprises subjecting crude human activin to a purification procedure involving, in particular, cation exchange chromatography by the chaotropic ion concentration gradient elution method. By using this process, highly pure human activin A appropriate for medicinal utilization can be easily isolated and purified from crude human activin, in particular, crude human activin A and human activin A can be produced on an industrial scale. Also, highly purified human activin which is obtained or might be obtained by the above process and human activin in the form of medicinal preparations are provided.

公开(公告)号：EP1489066A4

公开(公告)日：2006-05-31

申请号：EP03743568

申请日：2003-03-04

申请人： AJINOMOTO KK

发明人： YATAGAI MASANOBU ,  MINOMURA MASAFUMI ,  TSUCHIYA SHIGEKATSU

IPC分类号： C07C51/41 ,  C07C51/43 ,  C07C51/487 ,  C07C61/04 ,  C07B57/00 ,  C07C211/62

CPC分类号： C07C51/43 ,  C07B2200/07 ,  C07C51/412 ,  C07C51/487 ,  C07C2601/02 ,  C07C61/04

摘要： The invention provides a process for production of optically active 2,2-dimethylcyclopropanecarboxylic acid by reacting an optical isomer mixture of 2,2-dimethylcyclo- propanecarboxylic acid with an optically inactive amine to form (precipitate or crystallize) an ammonium salt of optically active 2,2-dimethylcyclopropanecarboxylic acid, e.g., optically active (S)-(+)-2,2-dimethylcyclopropanecarboxylic acid. According to the invention, the production (including optical resolution, separation of optical isomers, and purification of optical isomers) of optically active 2,2-dimethylcyclopropanecarboxylic acid important as an intermediate in the production of agricultural chemicals and drugs can be easily carried out at a low cost. Further, the invention provides intermediates for the above production (e.g., ammonium salts of optically active 2,2-dimethylcyclopropanecarboxylic acid, particularly, ammonium salts of optically active (S)-(+)-2,2-dimethyl- cyclopropanecarboxylic acid) and reagents for optical resolution for the separation of optically active 2,2- dimethylcyclopropanecarboxylic acid (e.g., optically inactive amines).