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    PROCESS FOR PRODUCING N-HALOGENATED ORGANIC COMPOUNDS
    1.
    发明授权
    PROCESS FOR PRODUCING N-HALOGENATED ORGANIC COMPOUNDS 无效
    用于生产有机n卤代化合物

    公开(公告)号：EP1250327B1

    公开(公告)日：2006-11-22

    申请号：EP01906581.2

    申请日：2001-01-17

    申请人： ALBEMARLE CORPORATION

    发明人： ELNAGAR, Hassan, Y. ,  PETERS, Bruce, C. ,  SPIELMAN, Edgar, E., Jr. ,  THOMAS, Dustin, H.

    IPC分类号： C07D233/82 ,  C07D251/36

    CPC分类号： C07D233/82

    摘要： The process enables highly effective N-halogenation of a compound having one or more halogenatable amido or imido functional groups in the molecule. The process involves, for example, concurrently feeding into a reactor (i) water, inorganic base, and the compound to be N-halogenated, e.g., a hydantoin, and a feed of (ii) a brominating agent and/or a chlorinating agent. The proportions of these feeds are such that the pH is kept within the range of ca. 5.5-8.5 (preferably 6.5-8.5, and most preferably 6.8-7.2) and one or more of the amido or imido nitrogen atoms is substituted by a bromine or chlorine atom. A feature of the processs is that it can be conducted at elevated temperatures as high as about 90 °C without appreciable thermal decomposition of reactants or product. The resultant product continuously precipitates in high yield and purity. Moreover, products can be produced that are very pale yellow to almost pure white in appearance. Further, the process has been found capable of producing 1,3-dibromo-5,5-dimethylhydantoin with far larger particle sizes than previously produced on a commercial basis.

    BENZYLIC HALOGENATION OF ALKYLBENZOIC ACID ESTERS
    2.
    发明公开
    BENZYLIC HALOGENATION OF ALKYLBENZOIC ACID ESTERS 审中-公开
    烷基苯甲酸酯的苯甲基卤化反应

    公开(公告)号：EP1161411A2

    公开(公告)日：2001-12-12

    申请号：EP00916203.3

    申请日：2000-03-08

    申请人： ALBEMARLE CORPORATION

    发明人： ELNAGAR, Hassan, Y.

    IPC分类号： C07C69/78 ,  C07C67/307

    CPC分类号： C07C67/307 ,  C07C69/76

    摘要： Direct preparation of benzylically halogenated alkylbenzoic acid ester from an alkylbenzoic acid ester in which the alkyl group is a primary or secondary alkyl group is carried out. The ester group of the starting ester (i) is devoid of non-aromatic unsaturation and (ii) if an aromatic group, is devoid of ring substitution that would undergo benzylic halogenation. The process comprises slowly feeding halogen continuously and/or intermittently to an agitated solution of the alkylbenzoic acid ester in a liquid halogen-containing solvent maintained at a thermal halogenation temperature such that when the alkyl group of the alkylbenzoic acid ester is a primary alkyl group and monohalogenation is desired, the total amount of halogen fed does not exceed about 0.8 mole of halogen per mole of alkylbenzoic acid ester. If the alkylbenzoic acid ester is a toluic acid ester and dihalogenation is desired, the amount of halogen fed is over (1) mole but no more than about 1.8 moles per mole of the toluic acid ester. Ester cleavage is minimized and other advantages are made possible.

    摘要翻译： 由其中烷基为伯或仲烷基的烷基苯甲酸酯直接制备苄基卤化的烷基苯甲酸酯。 起始酯（i）的酯基不含非芳香族不饱和基团，和（ii）如果芳香族基团没有经历苄基卤化的环取代。 该方法包括将卤素连续和/或间歇地缓慢加入保持在热卤化温度下的液体含卤素溶剂中的烷基苯甲酸酯的搅拌溶液中，使得当烷基苯甲酸酯的烷基为伯烷基时，和 单卤化是理想的，每摩尔烷基苯甲酸酯加入的卤素总量不超过约0.8摩尔卤素。 如果烷基苯甲酸酯是甲苯甲酸酯并且需要二卤化，则加入的卤素的量超过（1）摩尔但不超过约1.8摩尔/摩尔甲苯甲酸酯。 酯分解最小化，其他优点成为可能。

    PROCESS FOR PRODUCING N-HALOGENATED ORGANIC COMPOUNDS
    3.
    发明公开
    PROCESS FOR PRODUCING N-HALOGENATED ORGANIC COMPOUNDS 审中-公开
    方法生产N-卤化有机化合物

    公开(公告)号：EP1778645A2

    公开(公告)日：2007-05-02

    申请号：EP05771462.8

    申请日：2005-07-12

    申请人： ALBEMARLE CORPORATION

    发明人： ELNAGAR, Hassan, Y. ,  PETERS, Bruce, C ,  SPIELMAN, Edge, E., Jr. ,  THOMAS, Dustin, H.

    IPC分类号： C07D233/82

    CPC分类号： C07D233/82

    摘要： The process enables highly effective N-halogenation of a compound having one or more halogenatable amido or imido functional groups in the molecule. The process involves, for example, concurrently feeding into a reactor (i) water, inorganic base, and the compound to be N-halogenated, e.g., a hydantoin, and a feed of (ii) a brominating agent and/or a chlorinating agent. The proportions of these feeds are such that the pH is kept at 5 or below or within a specified range e.g., 5.5-8.5 and one or more of the amido or imido nitrogen atoms is substituted by a bromine or chlorine atom. A feature of the process is that it can be conducted at elevated temperatures as high as about 90°C without appreciable thermal decomposition of reactants or product. The resultant product continuously precipitates in high yield and purity. Moreover, products can be produced that are very pale yellow to almost pure white in appearance. Further, the process has been found capable of producing 1,3-dibromo-5,5-dimethylhydantoin with far larger particle sizes than previously produced on a commercial basis.

    SYNTHESIS OF CYCLOALKYLDIARYLPHOSPHINES
    5.
    发明公开
    SYNTHESIS OF CYCLOALKYLDIARYLPHOSPHINES 失效
    环烷基二芳基磷杂环戊二烯的合成

    公开(公告)号：EP0889896A1

    公开(公告)日：1999-01-13

    申请号：EP97916918.0

    申请日：1997-03-24

    申请人： ALBEMARLE CORPORATION

    发明人： SENARATNE, K., Pushpananda, A. ,  MALCOLM, Arcelio, J. ,  ORIHUELA, Felix, M. ,  ELNAGAR, Hassan, Y.

    IPC分类号： C07F9

    CPC分类号： C07F9/5077

    摘要： Partially sterically-hindered cycloalkyl chlorides are reacted with lithium diarylphosphides in inert liquid hydrocarbon reaction media to form cycloalkyldiarylphosphines. Aryl lithium is coproduced. The process makes it possible to avoid, or at least substantially eliminate, the interaction with or cleavage of cyclic ether reaction media such as tetrahydrofuran, previously the solvent of choice for conducting this type of reaction. Also during the conduct of the present process the chloro-substituted cycloalkane does not undergo any appreciable reaction with the coproduced aryl lithium as it is formed. Thus improvements both in yield and quality of the cycloalkyldiarylphosphine product are made possible. A comprehensive three-step process for converting triarylphosphine to cycloalkyldiarylphosphine is also described.

    摘要翻译： 部分空间位阻的环烷基氯化物与锂二芳基磷化物在惰性液体烃反应介质中反应形成环烷基二芳基膦。 芳基锂是联产的。 该方法可以避免或者至少基本上消除环醚反应介质如四氢呋喃与预先用于进行这类反应的溶剂的相互作用或裂解。 在进行本发明方法的过程中，氯取代的环烷烃在形成时与联产生的芳基锂不发生明显的反应。 因此，环烷基二芳基膦产物的收率和质量的改善成为可能。 还描述了将三芳基膦转化为环烷基二芳基膦的综合三步法。

    SYNTHESIS OF CYCLOALKYLDIARYLPHOSPHINES
    10.
    发明公开
    SYNTHESIS OF CYCLOALKYLDIARYLPHOSPHINES 失效
    环烷基二芳基磷杂环戊二烯的合成

    公开(公告)号：EP0889895A1

    公开(公告)日：1999-01-13

    申请号：EP97916917.0

    申请日：1997-03-24

    申请人： ALBEMARLE CORPORATION

    发明人： SENARATNE, K., Pushpananda, A. ,  MALCOLM, Arcelio, J. ,  ORIHUELA, Felix, M. ,  ELNAGAR, Hassan, Y.

    IPC分类号： C07F9

    CPC分类号： C07F9/5077

    摘要： By reacting certain partially sterically-hindered chloro-substituted cycloalkanes with sodium and/or potassium diarylphosphides in an ether reaction medium, not only are useful cycloalkyldiarylphosphines produced, but in addition the chloro-substituted cycloalkane does not undergo any appreciable reaction with the coproduced aryl sodium and/or aryl potassium as it is formed. Moreover, the process makes it possible to avoid or at least to greatly reduce interaction with or cleavage of cyclic ether reaction media such as tetrahydrofuran. Thus the process makes possible improvements both in yield and quality of the cycloalkyldiarylphosphite product. A two-stage process conducted in an ether reaction medium is also described. In the first stage the sodium and/or potassium diarylphosphine reactant is produced by reaction between sodium and/or potassium and triarylphosphine.

    摘要翻译： 通过在醚反应介质中使某些部分空间位阻的氯取代的环烷烃与二芳基磷酸钠和/或钾反应，不仅可以制备有用的环烷基二芳基膦，而且氯取代的环烷烃不会与共产生的芳基钠发生任何显着的反应 和/或芳基钾，因为它形成。 此外，该方法可避免或至少大大减少环醚反应介质如四氢呋喃的相互作用或裂解。 因此该方法可以在环烷基二芳基亚磷酸酯产物的产率和质量方面进行改进。 还描述了在醚反应介质中进行的两阶段过程。 在第一阶段中，钠和/或钾二芳基膦反应物通过钠和/或钾与三芳基膦之间的反应产生。