公开(公告)号：EP0977763A4

公开(公告)日：2000-07-12

申请号：EP98905150

申请日：1998-02-27

申请人： ALCHEMIA PTY LTD

发明人： TOTH ISTVAN ,  DEKANY GYULA ,  KELLAM BARRY

IPC分类号： C07H5/04 ,  C07H3/06 ,  C07H15/18 ,  C07H19/06 ,  C07H1/00 ,  C07H5/06 ,  C08B37/00

CPC分类号： C07H19/06 ,  C07H3/06 ,  C07H15/18 ,  Y02P20/55

摘要： The invention provides amine-protecting groups for use in solution phase or solid-phase oligosaccharide synthesis, in which a 2-substituted 1,3-dioxo compound is used to protect one or more primary amine groups of an aminosugar or glycosylamine. The invention provides reagents, reagent kits, and methods for solution phase, solid-phase oligosaccharide synthesis.

公开(公告)号：EP1017683A4

公开(公告)日：2002-03-06

申请号：EP98946145

申请日：1998-09-24

申请人： ALCHEMIA PTY LTD

发明人： TOTH ISTVAN ,  DEKANY GYULA ,  KELLAM BARRY

IPC分类号： C07D239/62 ,  C07H1/00 ,  C07H15/12 ,  C07H15/26 ,  C08J7/16 ,  A61K31/505 ,  C07C49/747 ,  C07H5/06 ,  C07H15/18

CPC分类号： C07H15/12 ,  C07D239/62

摘要： This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and linking groups which are useful in both solid phase and solution synthesis, and are particularly applicable to combinatorial synthesis. In its most general aspect, the invention provides a cyclic compound of general formula (I).

公开(公告)号：EP0923528A4

公开(公告)日：2000-07-19

申请号：EP97935368

申请日：1997-08-26

申请人： ALCHEMIA PTY LTD

发明人： TOTH ISTVAN ,  DEKANY GYULA ,  KELLAM BARRY

IPC分类号： C07H1/00 ,  C07B61/00 ,  C07C59/353 ,  C07C59/90 ,  C07C69/716 ,  C07C69/738 ,  C07C229/32 ,  C07C257/06 ,  C07H3/06 ,  C07H15/18 ,  C08J7/14 ,  C07H5/06 ,  C08J7/16

CPC分类号： C07H15/18 ,  C07C59/90 ,  C07C69/738 ,  C07H3/06

摘要： The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.