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公开(公告)号：EP0948357B1
公开(公告)日：2002-06-12
申请号：EP97947519.1
申请日：1997-11-17
发明人： ASGHARIAN, Bahram
CPC分类号： A61K33/22 , A61K9/0048 , A61K31/13 , A61K31/138 , A61K47/18 , A61L12/147 , Y10S514/839 , Y10S514/84 , Y10S514/912 , A61K2300/00
摘要： The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives. Particularly preferred amino alcohols are 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-2-methyl-1-propanediol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), and 2-amino-1-butanol (AB). The ophthalmic compositions further optionally comprise a borate/polyol buffer system and an alkylamine.
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公开(公告)号：EP0948357A1
公开(公告)日：1999-10-13
申请号：EP97947519.0
申请日：1997-11-17
发明人： ASGHARIAN, Bahram
CPC分类号： A61K33/22 , A61K9/0048 , A61K31/13 , A61K31/138 , A61K47/18 , A61L12/147 , Y10S514/839 , Y10S514/84 , Y10S514/912 , A61K2300/00
摘要： The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives. Particularly preferred amino alcohols are 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-2-methyl-1-propanediol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), and 2-amino-1-butanol (AB). The ophthalmic compositions further optionally comprise a borate/polyol buffer system and an alkylamine.
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3.发明公开STABLE LIQUID ENZYME COMPOSITIONS AND METHODS OF USE IN CONTACT LENS CLEANING AND DISINFECTING SYSTEMS 失效稳定的液体酶组合物及其使用清洁和DESINFIZIERUNGSSYSTEMEN隐形眼镜的方法
公开(公告)号：EP0771347A1
公开(公告)日：1997-05-07
申请号：EP96921427.0
申请日：1996-06-07
发明人： CHOWHAN, Masood, A. , QUINTANA, Ronald, P. , ASGHARIAN, Bahram , HONG, Bor-Shyue , BILBAULT, Thierry , ROSENTHAL, Ruth, Ann
CPC分类号： C11D3/046 , A61L12/082 , A61L12/145 , C11D3/0078 , C11D3/042 , C11D3/2044 , C11D3/2065 , C11D3/38618 , C11D3/38663 , C11D3/48
摘要： Stable liquid enzyme compositions containing an ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lenses. Methods for a daily use regimen are also disclosed.
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4.发明公开SWITCHABLE VISCOELASTIC SYSTEMS CONTAINING GALACTOMANNAN POLYMERS AND BORATE 失效GALAKTOMANNANPOLYMERE和波拉特含有可调粘度粘弹性系统
公开(公告)号：EP0999854A1
公开(公告)日：2000-05-17
申请号：EP98936846.9
申请日：1998-07-17
发明人： ASGHARIAN, Bahram
CPC分类号： A61L31/16 , A61K9/0048 , A61K47/02 , A61K47/36 , A61L31/041 , A61L31/042 , A61L31/14 , A61L2300/00 , A61L2430/16 , Y10S514/944 , C08L5/00 , C08L71/00
摘要： The present invention is directed to viscoelastic systems comprising a combination of a galactomannan polysaccharide containing composition and borate containing composition. The two compositions gel or partially gel upon combination. The present invention also discloses methods of using the systems during surgery and, in particular, eye surgery.
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公开(公告)号：EP0970175A1
公开(公告)日：2000-01-12
申请号：EP98935663.9
申请日：1998-07-17
发明人： ASGHARIAN, Bahram
CPC分类号： C11D3/046 , A61L2/0023 , A61L2/04 , A61L12/08 , C11D3/0078 , C11D3/042 , C11D3/222 , C11D3/225 , C11D17/003 , Y10S514/912 , Y10S514/944
摘要： Contact lens care compositions for the treatment of hard contact lenses are disclosed. The compositions are useful for rinsing, cleaning, disinfecting and storing of hard contact lenses. The compositions contain a unique gelling system involving galactomannan polysaccharides and borates to allow for the conditioning of the lens when it is reinserted in the eye of the user. Methods of using these compositions are also disclosed.
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公开(公告)号：EP0970175B1
公开(公告)日：2002-10-02
申请号：EP98935663.9
申请日：1998-07-17
发明人： ASGHARIAN, Bahram
CPC分类号： C11D3/046 , A61L2/0023 , A61L2/04 , A61L12/08 , C11D3/0078 , C11D3/042 , C11D3/222 , C11D3/225 , C11D17/003 , Y10S514/912 , Y10S514/944
摘要： Contact lens care compositions for the treatment of hard contact lenses are disclosed. The compositions are useful for rinsing, cleaning, disinfecting and storing of hard contact lenses. The compositions contain a unique gelling system involving galactomannan polysaccharides and borates to allow for the conditioning of the lens when it is reinserted in the eye of the user. Methods of using these compositions are also disclosed.
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7.发明公开OPHTHALMIC COMPOSITIONS CONTAINING GALACTOMANNAN POLYMERS AND BORATE 失效GALAKTOMANNANPOLYMERE和含有波拉特眼部药物
公开(公告)号：EP0999825A1
公开(公告)日：2000-05-17
申请号：EP98936847.7
申请日：1998-07-17
发明人： ASGHARIAN, Bahram
CPC分类号： A61K31/74 , A61K9/0048 , A61K33/22 , A61K45/06 , A61K47/02 , A61K47/36 , Y10S514/839 , Y10S514/912 , Y10S514/944 , A61K2300/00
摘要： The present invention is directed to ophthalmic compositions containing a gelling amount of a combination of galactomannan polysaccharides and borates. The compositions gel or partially gel upon administration to the eye. The present invention also discloses methods of topical ophthalmic administration of the compositions of the eye.
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8.发明公开
公开(公告)号：EP0946208A2
公开(公告)日：1999-10-06
申请号：EP97950687.0
申请日：1997-11-24
发明人： ASGHARIAN, Bahram
CPC分类号： A61L12/086
摘要： Two-compartment bottle assemblies useful in preparing multi-purpose compositions containing an ophthalmically acceptable enzyme and disinfectant, methods of preparing these compositions and methods involving the use of these compositions are disclosed for cleaning and disinfecting of contact lenses.
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9.发明授权OPHTHALMIC COMPOSITIONS CONTAINING GALACTOMANNAN POLYMERS AND BORATE 失效GALAKTOMANNANPOLYMERE和含有波拉特眼部药物
公开(公告)号：EP0999825B1
公开(公告)日：2003-10-01
申请号：EP98936847.7
申请日：1998-07-17
发明人： ASGHARIAN, Bahram
CPC分类号： A61K31/74 , A61K9/0048 , A61K33/22 , A61K45/06 , A61K47/02 , A61K47/36 , Y10S514/839 , Y10S514/912 , Y10S514/944 , A61K2300/00
摘要： The present invention is directed to ophthalmic compositions containing a gelling amount of a combination of galactomannan polysaccharides and borates. The compositions gel or partially gel upon administration to the eye. The present invention also discloses methods of topical ophthalmic administration of the compositions of the eye.
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公开(公告)号：EP0772669B1
公开(公告)日：2001-10-10
申请号：EP95926714.7
申请日：1995-07-17
发明人： ASGHARIAN, Bahram , CHOWHAN, Masood , STACH, Paul
CPC分类号： C11D3/48 , A61L12/14 , C11D1/04 , C11D1/72 , C11D1/83 , C11D3/0078 , C11D3/046 , C11D3/2065 , C11D3/33 , Y10S514/839 , Y10S514/912 , Y10S514/915
摘要： Improved saline solutions useful in treating contact lenses are described. Unlike prior saline solutions used for similar purposes, the present solutions do not contain conventional antimicrobial agents which are potentially toxic to ocular tissues. Rather, the solutions contain a combinaison of a borate-polyol complex, one or more anionic or nonionic surfactants, and a low molecular weight amino acid (e.g., glycine). It has been found that this combination effectively preserves the saline solutions from antimicrobial contamination, is relatively nontoxic to ocular tissues, and is compatible with oxidizing agents used in certain contact lens disinfecting systems. The combination also facilitates the cleaning of contact lenses.
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