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1.发明公开PROCESS FOR THE PRODUCTION OF 16,17- (CYCLOHEXYLMETHYLEN)BIS(OXY)]-11,21-DIHYDROXY-PREGNA-1,4-DIEN-3,20-DION OR ITS 21-ISOBUTYRAT BY TRANSKETALISATION 有权用于生产16.17 - [（环己基亚甲基）双（氧基）] -11,21二羟基 - 孕-1,4-二烯-3,20-二酮OR ITS 21异丁BY TRANSKETALISATION
公开(公告)号：EP1335929A1
公开(公告)日：2003-08-20
申请号：EP01990391.3
申请日：2001-11-06
申请人： ALTANA Pharma AG
发明人： GUTTERER, Beate
IPC分类号： C07J71/00
CPC分类号： C07J71/0031
摘要： The invention relates to a process for the preparation of 16,17-[(cyclohexylmethylene)bis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione[11β,16α(R)] and similar compounds, by reaction of an appropri-ate 16,17-ketal with cyclohexanealdehyde.
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公开(公告)号：EP1147087B1
公开(公告)日：2005-05-11
申请号：EP00901089.3
申请日：2000-01-12
申请人： ALTANA Pharma AG
发明人： FLOCKERZI, Dieter , AMSCHLER, Hermann DI , HATZELMANN, Armin , BUNDSCHUH, Daniela , BEUME, Rolf , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/435 , A61P11/08
CPC分类号： C07D221/12
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公开(公告)号：EP1000034B1
公开(公告)日：2002-09-18
申请号：EP98942571.5
申请日：1998-07-18
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , FLOCKERZI, Dieter , ULRICH, Wolf-Rüdiger , BÄR, Thomas , MARTIN, Thomas , SCHUDT, Christian , HATZELMANN, Armin , BEUME, Rolf , HÄFNER, Dietrich , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/435 , C07D491/04
CPC分类号： C07D491/04 , C07D221/12
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公开(公告)号：EP0828728B1
公开(公告)日：2003-01-22
申请号：EP96916048.0
申请日：1996-05-11
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , BÄR, Thomas , GUTTERER, Beate , FLOCKERZI, Dieter , MARTIN, Thomas , THIBAUT, Ulrich , HATZELMANN, Armin , BEUME, Rolf , BOSS, Hildegard , HÄFNER, Dietrich , KLEY, Hans-Peter , ULRICH, Wolf-Rüdiger
IPC分类号： C07D307/94 , C07D307/86 , A61K31/34
CPC分类号： C07D307/94 , C07D307/86
摘要： Compounds having the formula (I), in which R1, R2, R3, R4 and R5 have the meanings given in the description, are new and powerful PDE inhibitors.
摘要翻译： 具有式（I）的化合物（其中R1，R2，R3，R4和R5具有说明书中给出的含义）是新的和强大的PDE抑制剂。
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公开(公告)号：EP1250325A1
公开(公告)日：2002-10-23
申请号：EP01909597.5
申请日：2001-01-10
申请人： ALTANA Pharma AG
发明人： FLOCKERZI, Dieter , GRUNDLER, Gerhard , HATZELMANN, Armin , BUNDSCHUH, Daniela , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/473 , A61P11/06
CPC分类号： C07D221/12
摘要： N-oxides of the compounds of formula (I) in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R6 is an R7- and R8-substituted phenyl radical, they are active bronchial therapeutics.
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6.发明授权POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY 有权WITH PDE-IV抑制活性多取代的6- PHENYLPHENANTHRIDINES
公开(公告)号：EP1163226B1
公开(公告)日：2007-03-14
申请号：EP00907464.2
申请日：2000-01-12
申请人： ALTANA Pharma AG
发明人： FLOCKERZI, Dieter , AMSCHLER, Hermann , GRUNDLER, Gerhard , HATZELMANN, Armin , BUNDSCHUH, Daniela , BEUME, Rolf , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/435 , A61P11/08
CPC分类号： C07D221/12
摘要： Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics.
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公开(公告)号：EP1147089B1
公开(公告)日：2005-12-07
申请号：EP00901534.8
申请日：2000-01-12
申请人： ALTANA Pharma AG
发明人： FLOCKERZI, Dieter , AMSCHLER, Hermann DI , GRUNDLER, Gerhard , HATZELMANN, Armin , BUNDSCHUH, Daniela , BEUME, Rolf , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/435 , C07D401/10 , A61P11/08
CPC分类号： C07D401/12 , C07D221/12 , C07D401/10
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公开(公告)号：EP1075477B1
公开(公告)日：2003-03-12
申请号：EP99922133.6
申请日：1999-04-27
申请人： ALTANA Pharma AG
发明人： GUTTERER, Beate , AMSCHLER, Hermann , ULRICH, Wolf-Rüdiger , MARTIN, Thomas , BÄR, Thomas , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , BUNDSCHUH, Daniela , KLEY, Hans-Peter , FLOCKERZI, Dieter
IPC分类号： C07D471/04 , A61K31/44 , C07D491/14
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I) wherein R1, R2, R3 and R4 have the meanings given in the description. Said compounds are novel active bronchial therapeutic agents.
摘要翻译： 本发明涉及式（I）的化合物，其中R 1，R 2，R 3和R 4具有说明书中给出的含义。 所述化合物是新颖的活性支气管治疗剂。
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公开(公告)号：EP0889886B1
公开(公告)日：2002-09-18
申请号：EP97915422.6
申请日：1997-03-24
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , FLOCKERZI, Dieter , ULRICH, Wolf-Rüdiger , BÄR, Thomas , MARTIN, Thomas , SCHUDT, Christian , HATZELMANN, Armin , BEUME, Rolf , HÄFNER, Dietrich , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D401/04 , A61K31/435 , C07D491/04 , C07D221/12
CPC分类号： C07D401/04 , C07D221/12
摘要： Compounds of formula (I) in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings given in the description, are novel effective bronchial therapeutic agents.
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