利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.015 秒)

    TRYPTASE-INHIBITORS
    7.
    发明公开
    TRYPTASE-INHIBITORS 审中-公开
    类胰蛋白酶抑制剂

    公开(公告)号：EP1370518A2

    公开(公告)日：2003-12-17

    申请号：EP02724222.1

    申请日：2002-03-12

    申请人： ALTANA Pharma AG

    发明人： MARTIN, Thomas ,  ULRICH, Wolf-Rüdiger ,  BÄR, Thomas ,  STADLWIESER, Josef ,  WOLLIN, Stefan-Lutz ,  ZECH, Karl ,  SOMMERHOFF, Christian, P.

    IPC分类号： C07C271/20 ,  A61K31/192 ,  A61K31/194 ,  A61P11/00 ,  C07D213/30

    CPC分类号： C07C271/20

    摘要： Compounds of the formula I, wherein M, A1, A2, K1 and K2 have the meanings as indicated below are tryptase inhibitors. M is a central building block containing an acetylene containing linking group. A1 and A2 are carbonyl containing linking groups K1 is -B3-X1, -B3-Y1 or B3-Z1-B5-X1, K2 is -B4-X2, -B4-Y2 or -B4-Z2-B6-X2, B3 and B4 are identical or different and are a bond or 1-4C-alkylene, B5 and B6 are identical or different and are a bond or 1-2C-alkylene, X1 and X2 are identical or different and are amino, aminocarbonyl or amidino, Y1 and Y2 are imidazol -1-yl, Z1 and Z2 are identical or different and are 5,2-pyridinylene, 6-methyl-5,2-pyridinylene, 4,1-piperidinylene, 3,6-indazolylene, 3,6-indolylene, 1,3-phenylene, 1,4-phenylene, 1,3,-cyclohexalene or 1,4-cyclohexylene, the salts of these compounds, and the N-oxides of the nitrogen-containing heteroalryls, heteroarylenes and heterocycloalkylenes, and their salts, where all those compounds are excluded in which, owing to the meaning of the variables, there would be a direct linkage of two hereroatoms or two carbonyl groups.

    摘要翻译： 其中M，A1，A2，K1和K2具有如下所示含义的式I化合物是类胰蛋白酶抑制剂。 M是含有含乙炔连接基团的中央构件。 A1和A2是含羰基连接基团，K1是-B3-X1，-B3-Y1或B3-Z1-B5-X1，K2是-B4-X2，-B4-Y2或-B4-Z2-B6-X2，B3 和B 4是相同或不同的并且是键或1-4C-亚烷基，B 5和B 6相同或不同并且是键或1-2C-亚烷基，X 1和X 2相同或不同并且是氨基，氨基羰基或脒基， Y1和Y2是咪唑-1-基，Z1和Z2相同或不同，并且是5,2-亚吡啶基，6-甲基-5,2-亚吡啶基，4,1-亚哌啶基，3,6-吲唑基，3,6 - 亚苯基，1,3-亚苯基，1,4-亚苯基，1,3-环己烯或1,4-亚环己基，这些化合物的盐以及含氮杂芳基，亚杂芳基和杂环亚烷基的N-氧化物， 和它们的盐，其中排除了所有这些化合物，其中由于这些变量的含义，将存在两个下游或两个羰基的直接连接。