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公开(公告)号：EP1095040B1
公开(公告)日：2004-03-31
申请号：EP99931198.8
申请日：1999-06-26
申请人： ALTANA Pharma AG
发明人： ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , BÄR, Thomas , FLOCKERZI, Dieter , SCHMIDT, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KLEY, Hans-Peter , HÄFNER, Dietrich , MARTIN, Thomas
IPC分类号： C07D413/04 , C07D263/56 , A61K31/42
CPC分类号： C07D263/56 , C07D413/04
摘要： Compounds of formula (I) in which R1, R2, R3 and A have the meanings indicated in the description, are novel efficacious PDE inhibitors.
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公开(公告)号：EP1075476B1
公开(公告)日：2003-06-04
申请号：EP99920814.3
申请日：1999-04-29
申请人： ALTANA Pharma AG
发明人： MARTIN, Thomas , ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , SCHMIDT,Beate , FLOCKERZI, Dieter , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KILIAN, Ulrich , KLEY, Hans-Peter , BÄR, Thomas
IPC分类号： C07D413/00 , A61K31/42 , A61K31/415 , C07D405/04 , C07D413/04 , C07D413/14
CPC分类号： C07D405/04 , C07D413/04 , C07D413/14
摘要： The invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and Y have the meanings given in the description. Said compounds are novel active bronchial therapeutic agents.
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公开(公告)号：EP1000034B1
公开(公告)日：2002-09-18
申请号：EP98942571.5
申请日：1998-07-18
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , FLOCKERZI, Dieter , ULRICH, Wolf-Rüdiger , BÄR, Thomas , MARTIN, Thomas , SCHUDT, Christian , HATZELMANN, Armin , BEUME, Rolf , HÄFNER, Dietrich , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/435 , C07D491/04
CPC分类号： C07D491/04 , C07D221/12
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4.发明授权
公开(公告)号：EP1147088B1
公开(公告)日：2006-01-04
申请号：EP00901530.6
申请日：2000-01-12
申请人： ALTANA Pharma AG
发明人： FLOCKERZI, Dieter , AMSCHLER, Hermann DI , GRUNDLER, Gerhard , HATZELMANN, Armin , BUNDSCHUH, Daniela , BEUME, Rolf , BOSS, Hildegard , GOEBEL, Karl-Josef , KLEY, Hans-Peter , SCHMIDT, Beate
IPC分类号： C07D221/12 , A61K31/435 , A61P11/08 , C07D401/04 , C07D405/04
CPC分类号： C07D401/04 , C07D221/12 , C07D401/12 , C07D405/04 , C07D409/04 , C07D491/04
摘要： Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and Ar have the meanings indicated in the description, are novel active bronchial therapeutics.
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5.发明公开
公开(公告)号：EP1567140A1
公开(公告)日：2005-08-31
申请号：EP03780056.2
申请日：2003-11-26
申请人： ALTANA Pharma AG
IPC分类号： A61K31/167 , A61K31/44 , A61P11/00
CPC分类号： A61K31/44 , A61K31/167 , A61K2300/00
摘要： The invention relates to the combined administration of roflumilast and R,R-formoterol for the treatment of respiratory tract disorders.
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公开(公告)号：EP1567139A1
公开(公告)日：2005-08-31
申请号：EP03767663.2
申请日：2003-11-26
申请人： ALTANA Pharma AG
IPC分类号： A61K31/167 , A61K31/44 , A61P11/00
CPC分类号： A61K31/44 , A61K31/167 , A61K2300/00
摘要： The invention relates to the combined administration of roflumilast and formoterol for the treatment of respiratory tract disorders.
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公开(公告)号：EP1147087B1
公开(公告)日：2005-05-11
申请号：EP00901089.3
申请日：2000-01-12
申请人： ALTANA Pharma AG
发明人： FLOCKERZI, Dieter , AMSCHLER, Hermann DI , HATZELMANN, Armin , BUNDSCHUH, Daniela , BEUME, Rolf , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/435 , A61P11/08
CPC分类号： C07D221/12
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公开(公告)号：EP0920426B9
公开(公告)日：2005-04-06
申请号：EP97940080.1
申请日：1997-08-13
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , MARTIN, Thomas , FLOCKERZI, Dieter , Schmidt, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , KLEY, Hans-Peter , BEUME, Rolf , BÄR, Thomas , ULRICH, Wolf-Rüdiger
IPC分类号： C07D401/14 , A61K31/425
CPC分类号： C07D417/04 , C07D417/14
摘要： Compounds having the formula (I), in which R1, R2, R3, R4 and n have the meanings given in the description, are new effective bronchotherapeutic agents (phosphodiesterase IV inhibitors).
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9.发明公开PHARMACEUTICAL COMPOSITION OF A PDE4 OR A PDE3/4 INHIBITOR AND A HISTAMINE RECEPTOR ANTAGONIST 有权药物组合物包含PDE4或PDE3 / 4抑制剂和组胺受体拮抗剂
公开(公告)号：EP1482938A1
公开(公告)日：2004-12-08
申请号：EP03708130.4
申请日：2003-02-25
申请人： ALTANA Pharma AG
IPC分类号： A61K31/4425 , A61K31/4523 , A61K31/4375 , A61K45/06 , A61P11/06 , A61P11/08
CPC分类号： A61K9/0073 , A61K31/4375 , A61K31/4425 , A61K31/4523 , A61K45/06 , A61K2300/00
摘要： The invention relates to the combined administration of PDE4 or PDE3/4 inhibitors and histamine receptor antagonists for the treatment of respiratory diseases.
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公开(公告)号：EP1070056B1
公开(公告)日：2004-06-30
申请号：EP99914474.4
申请日：1999-03-04
申请人： ALTANA Pharma AG
发明人： HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , BEUME, Rolf , KLEY, Hans-Peter , VAN DER LAAN, Ivonne, Johanna , TIMMERMAN, Hendrik , STERK, Geert, Jan , VAN DER MEY, Margaretha
IPC分类号： C07D237/32 , A61K31/50 , C07D417/12 , A61K31/54
CPC分类号： C07D237/32 , C07D417/12
摘要： The compounds of formula (I) in which R1, R2, R3, R4, R5, X and Y have the meanings as given in the description are novel effective bronchial therapeutica.
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