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1.发明授权SUSTAINED DRUG RELEASE COMPOSITION DEMONSTRATING AN ASCENDING ZERO ORDER RELEASE PATTERN, METHODS OF MANUFACTURING SUCH A COMPOSITION 有权与上升的零级释放时滞PATTERN释放药物成分; 用于制备这种组合物“
公开(公告)号：EP1802286B1
公开(公告)日：2008-07-23
申请号：EP05779051.1
申请日：2005-08-02
申请人： ALZA CORPORATION
发明人： CASADEVALL, Gemma , SUBRAMANIAN, Ramkumar , BARCLAY, Brian , ALLPHIN, Clark , SHIVANAND, Padmaja , YAM, Noymi, V.
CPC分类号： A61K9/1635 , A61K9/1652 , A61K9/2054 , A61K9/2077 , A61K9/2081 , A61K9/209 , A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K9/5084 , A61K31/519
摘要： Disclosed are dosage forms and methods for sustained release of a drug including : a delay layer comprising a polymeric matrix, and microencapsulated drug, wherein the delay layer is substantially free of non-microencapsulated drug; and a second layer including a polymeric matrix, and non-microencapsulated drug matrix; wherein the second layer is located adjacent to the delay layer.
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2.发明公开SUSTAINED DRUG RELEASE COMPOSITION DEMONSTRATING AN ASCENDING ZERO ORDER RELEASE PATTERN, METHODS OF MANUFACTURING SUCH A COMPOSITION 有权与上升的零级释放时滞PATTERN释放药物成分; 用于制备这种组合物“
公开(公告)号：EP1802286A1
公开(公告)日：2007-07-04
申请号：EP05779051.1
申请日：2005-08-02
申请人： ALZA CORPORATION
发明人： CASADEVALL, Gemma , SUBRAMANIAN, Ramkumar , BARCLAY, Brian , ALLPHIN, Clark , SHIVANAND, Padmaja , YAM, Noymi, V.
CPC分类号： A61K9/1635 , A61K9/1652 , A61K9/2054 , A61K9/2077 , A61K9/2081 , A61K9/209 , A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K9/5084 , A61K31/519
摘要： Disclosed are dosage forms and methods for sustained release of a drug including : a delay layer comprising a polymeric matrix, and microencapsulated drug, wherein the delay layer is substantially free of non-microencapsulated drug; and a second layer including a polymeric matrix, and non-microencapsulated drug matrix; wherein the second layer is located adjacent to the delay layer.
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