公开(公告)号：EP1658048A2

公开(公告)日：2006-05-24

申请号：EP04781374.6

申请日：2004-08-18

申请人： ALZA CORPORATION

发明人： YAM, Noymi, V. ,  SHIVANAND, Padmaja ,  KIMBEL, Rhea ,  ALLPHIN, Clark, P. ,  WONG, Patrick, S., L.

IPC分类号： A61K9/00

CPC分类号： A61K9/0004

摘要： Compositions and dosage forms for enhanced dispersion of topiramate in a controlled release dosage form released from the dosage form as a dry or substantially dry erodible solid over a prolonged period of time at a stepwise increasing rate of release are described.

公开(公告)号：EP1802286B1

公开(公告)日：2008-07-23

申请号：EP05779051.1

申请日：2005-08-02

申请人： ALZA CORPORATION

发明人： CASADEVALL, Gemma ,  SUBRAMANIAN, Ramkumar ,  BARCLAY, Brian ,  ALLPHIN, Clark ,  SHIVANAND, Padmaja ,  YAM, Noymi, V.

IPC分类号： A61K9/50 ,  A61K9/20

CPC分类号： A61K9/1635 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2081 ,  A61K9/209 ,  A61K9/5026 ,  A61K9/5047 ,  A61K9/5073 ,  A61K9/5084 ,  A61K31/519

摘要： Disclosed are dosage forms and methods for sustained release of a drug including : a delay layer comprising a polymeric matrix, and microencapsulated drug, wherein the delay layer is substantially free of non-microencapsulated drug; and a second layer including a polymeric matrix, and non-microencapsulated drug matrix; wherein the second layer is located adjacent to the delay layer.

公开(公告)号：EP1539115B1

公开(公告)日：2007-09-19

申请号：EP03771910.1

申请日：2003-07-28

申请人： ALZA CORPORATION

发明人： YAM, Noymi, V. ,  REYES, Iran ,  DAVAR, Nipun ,  AYER, Atul, D. ,  LEE, Julie

IPC分类号： A61K9/24 ,  A61K31/506 ,  A61P25/18

CPC分类号： A61K31/506 ,  A61K9/0004 ,  A61K31/519

摘要： Dosage forms and methods for providing a substantially ascending rate of release of paliperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone concentration that occurs following administration of paliperidone in an immediate-release dosage form.

公开(公告)号：EP1802286A1

公开(公告)日：2007-07-04

申请号：EP05779051.1

申请日：2005-08-02

申请人： ALZA CORPORATION

发明人： CASADEVALL, Gemma ,  SUBRAMANIAN, Ramkumar ,  BARCLAY, Brian ,  ALLPHIN, Clark ,  SHIVANAND, Padmaja ,  YAM, Noymi, V.

IPC分类号： A61K9/50 ,  A61K9/20

CPC分类号： A61K9/1635 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2081 ,  A61K9/209 ,  A61K9/5026 ,  A61K9/5047 ,  A61K9/5073 ,  A61K9/5084 ,  A61K31/519

摘要： Disclosed are dosage forms and methods for sustained release of a drug including : a delay layer comprising a polymeric matrix, and microencapsulated drug, wherein the delay layer is substantially free of non-microencapsulated drug; and a second layer including a polymeric matrix, and non-microencapsulated drug matrix; wherein the second layer is located adjacent to the delay layer.

公开(公告)号：EP1539115A1

公开(公告)日：2005-06-15

申请号：EP03771910.1

申请日：2003-07-28

申请人： ALZA Corporation

发明人： YAM, Noymi, V. ,  REYES, Iran ,  DAVAR, Nipun ,  AYER, Atul, D. ,  LEE, Julie

IPC分类号： A61K9/24 ,  A61K31/506 ,  A61P25/18

CPC分类号： A61K31/506 ,  A61K9/0004 ,  A61K31/519

摘要： Dosage forms and methods for providing a substantially ascending rate of release of paliperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone concentration that occurs following administration of paliperidone in an immediate-release dosage form.

公开(公告)号：EP1503732B1

公开(公告)日：2008-10-08

申请号：EP03747606.6

申请日：2003-04-28

申请人： ALZA Corporation

发明人： SEROFF, Sylvia, L. ,  YAM, Noymi, V. ,  AYER, Atul, D. ,  LAM, Andrew, C.

IPC分类号： A61K9/00 ,  A61K47/34 ,  A61K31/765

CPC分类号： A61K31/5375 ,  A61K9/0004 ,  A61K9/2031 ,  A61K31/765 ,  A61K47/34

摘要： Oral delivery vehicles and compositions for providing sustained release of secondary amines including reboxetine with reduced formate poly(alkylene oxide) polymers are provided. Processes for reducing the amount of the formic compounds from the polymers comprising contacting the polymers with an acid having a Pka lower than that of formic acid are also disclosed.

公开(公告)号：EP1503732A2

公开(公告)日：2005-02-09

申请号：EP03747606.6

申请日：2003-04-28

申请人： Alza Corporation

发明人： SEROFF, Sylvia, L. ,  YAM, Noymi, V. ,  AYER, Atul, D. ,  LAM, Andrew, C.

IPC分类号： A61K9/00 ,  A61K47/34 ,  A61K31/765

CPC分类号： A61K31/5375 ,  A61K9/0004 ,  A61K9/2031 ,  A61K31/765 ,  A61K47/34

摘要： Oral delivery vehicles and compositions for providing sustained release of secondary amines including reboxetine with reduced formate poly(alkylene oxide) polymers are provided. Processes for reducing the amount of the formic compounds from the polymers comprising contacting the polymers with an acid having a Pka lower than that of formic acid are also disclosed.