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1.发明公开COATING SUSPENSIONS (COMPRISING OSMOPOLYMERS, OSMAGENTS) FOR FORMING AN EXPANDABLE OSMOTIC COMPOSITION IN CONTROLLED RELEASE DOSAGE FORMS AS WELL AS THE CORRESPONDING METHOD FOR PROVIDING THIS OSMOTIC COATING 审中-公开涂料悬浮液（如何渗透调节物质包括渗透聚合物）教育渗透可膨胀组合物适用剂型为这个OSMOTIC涂层控释和等效生产方法
公开(公告)号：EP1528913A1
公开(公告)日：2005-05-11
申请号：EP03762340.2
申请日：2003-06-28
申请人： Alza Corporation
IPC分类号： A61K9/00 , A61K9/28 , A61K9/10 , A61K9/48 , A61K31/085
CPC分类号： A61K9/0004 , A61K31/085
摘要： The present invention includes an expandable osmotic layer and a coating suspension for providing an expandable osmotic layer, both of which are useful for the manufacture of controlled release dosage forms. The expandable osmotic layer of the present invention may be produced using the coating suspension of the present invention. Advantageously, the coating suspension of the present invention can be used to coat expandable osmotic layers under both wet and dry process conditions without sacrificing the quality of the expandable osmotic layers produced, and therefore provides a relatively robust coating suspension that facilitates commercial production of controlled release dosage forms including a coated expandable osmotic layer.
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2.发明公开UNIFORM DELIVERY OF TOPIRAMATE OVER PROLONGED PERIOD OF TIME WITH ENHANCED DISPERSION FORMULATION 审中-公开给料均匀托吡酯在具有改进的分散体制剂延长的时间
公开(公告)号：EP1653922A2
公开(公告)日：2006-05-10
申请号：EP04780043.8
申请日：2004-08-03
申请人： ALZA CORPORATION
CPC分类号： A61K9/2866 , A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2086 , A61K9/209 , A61K9/4866 , A61K31/35
摘要： Compositions and dosage forms for enhanced dispersion of topiramate in a controlled release dosage form delivered as a dry or substantially dry erodible solid at a uniform rate over a prolonged period of time are described.
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公开(公告)号：EP1684713A1
公开(公告)日：2006-08-02
申请号：EP04819096.1
申请日：2004-11-12
申请人： ALZA CORPORATION
发明人： LI, Shaoling , LAM, Andrew , DONG, Liang
CPC分类号： A61K31/35 , A61K9/0004
摘要： This invention relates to novel formulations and methods for the controlled release delivery of topiramate; as well as to the use of these formulations and methods for treating disease.
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公开(公告)号：EP1534238A1
公开(公告)日：2005-06-01
申请号：EP03771915.0
申请日：2003-07-28
申请人： ALZA Corporation
发明人： JAO, Frank , EDGREN, David , WONG, Patrick, S.L. , SKLUZACEK, Robert , LI, Shu , LAM, Andrew , AYER, Atul, D. , LI, Shaoling , TO, Winnie
CPC分类号： A61K31/35 , A61K9/0004
摘要： Dosage forms and devices for enhancing controlled delivery of lowly soluble active agents including topiramate by use of a drug core composition that increases the solubility of the pharmaceutical agent are described. The present invention provides a drug core composition for delivering high doses of lowly soluble topiramate in solid oral drug delivery systems that are convenient to swallow, for once-a-day administration. The drug core composition contains topiramate, a surfactant and a carrier in ratios for optimal solubility and delivery.
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5.发明公开DOSAGE FORMS FOR INCREASING THE SOLUBILITY AND EXTENDING THE RELEASE OF DRUGS SUCH AS E.G. TOPIRAMATE AND PHENYTON 审中-公开方法和剂量形式溶解度增加等物质作为KONTROLIERTEN分布 托吡酯和苯妥英
公开(公告)号：EP1517671A2
公开(公告)日：2005-03-30
申请号：EP03742204.5
申请日：2003-06-26
申请人： Alza Corporation
发明人： EDGREN, David , WONG, Patrick, S., L. , JAO, Frank , SKLUZACEK, Robert , LI, Shu , LAM, Andrew , BHATTI, Gurdish , LI, Shaoling , AYER, Atul , TO, Winnie
IPC分类号： A61K9/00 , A61K9/20 , A61K31/35 , A61K31/4166 , A61P25/08
CPC分类号： A61K31/4166 , A61K9/0004 , A61K31/35 , A61K47/34
摘要： Dosage forms and devices for enhancing controlled delivery of pharmaceutical agents by use of a drug core composition containing a polymer carrier (e.g. polyethylene oxide) and a surfactant (e.g. polyoxyl stearate, poloxamer) that increases the solubility of the pharmaceutical agent are described. The present invention provides a means of delivering high doses of lowly soluble drug in oral drug delivery systems that are convenient to swallow, for once-a-day administration. Osmotic devices are described.
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公开(公告)号：EP1381352B1
公开(公告)日：2007-06-13
申请号：EP02715112.5
申请日：2002-03-15
申请人： Alza Corporation
发明人： VENKATRAMAN, Subramanian, S. , LI, Shaoling , GALE, Robert, M. , STEPIC, Jane , VAN OSDOL, William, W.
IPC分类号： A61K9/70 , A61K31/4468
CPC分类号： A61K31/4468 , A61K9/0014 , A61K9/703 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/4535 , A61K47/14 , A61K47/22 , A61K47/32 , A61K47/34
摘要： A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
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公开(公告)号：EP1701708A2
公开(公告)日：2006-09-20
申请号：EP04815922.2
申请日：2004-12-28
申请人： ALZA CORPORATION
发明人： EDGREN, David , JAO, Frank , KIMBEL, Rhea , LI, Shaoling , YAM, Noymi , SEROFF, Sylvia Lillian , SHIVANAND, Padmaja
CPC分类号： A61K9/0004 , A61K9/209 , A61K31/35
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and / or low dissolution rate pharmacuetical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
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公开(公告)号：EP1701706A2
公开(公告)日：2006-09-20
申请号：EP04815919.8
申请日：2004-12-28
申请人： ALZA CORPORATION
发明人： EDGREN, David , JAO, Frank , KIMBEL, Rhea , LI, Shaoling , YAM, Noymi , SEROFF, Sylvia Lillian , SHIVANAND, Padmaja
CPC分类号： A61K9/209 , A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmacuetical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
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公开(公告)号：EP1381352A1
公开(公告)日：2004-01-21
申请号：EP02715112.5
申请日：2002-03-15
申请人： Alza Corporation
发明人： VENKATRAMAN, Subramanian, S. , LI, Shaoling , GALE, Robert, M. , STEPIC, Jane , VAN OSDOL, William, W.
IPC分类号： A61K9/70 , A61K31/4468
CPC分类号： A61K31/4468 , A61K9/0014 , A61K9/703 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/4535 , A61K47/14 , A61K47/22 , A61K47/32 , A61K47/34
摘要： A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
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