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1.发明公开DRUG GRANULE COATINGS THAT IMPART SMEAR RESISTANCE DURING MECHANICAL COMPRESSION 审中-公开药物颗粒涂料耐油性机械压缩奖
公开(公告)号：EP1701707A2
公开(公告)日：2006-09-20
申请号：EP04815921.4
申请日：2004-12-28
发明人： EDGREN, David , KHAN, Alya , QURESHI, Abdul Majid , ERGUN, James , RAMACHANDRAN, Satishkumar , YAM, Noymi
CPC分类号： A61K9/0004 , A61K9/5026 , A61K9/5047
摘要： A drug formulation is disclosed comprising granules having a substrate and a coating, said granule substrate comprising a solubilizing surfactant or a low solubility therapeutic drug, or both, and said granule coating comprising a hydrophilic polymer. Also disclosed is a drug formulation consisting of a tablet core made by mechanical compression, wherein said tablet core comprises granules having a substrate and a coating, said granule substrate comprising a solubilizing surfactant or a low solubility therapeutic drug, or both, and said granule coating comprising a hydrophilic polymer. Also disclosed is a dosage form for oral administration of topiramate, comprising a tablet core and an osmotic delivery system. Methods for controlling topiramate release patterns by altering the composition of the topiramate dosage form are also disclosed.
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公开(公告)号：EP1126853B1
公开(公告)日：2006-04-19
申请号：EP99971322.5
申请日：1999-10-26
申请人： ALZA CORPORATION
发明人： CRUZ, Evangeline, G. , YAM, Noymi , ZHONG, Adam , AYER, Atul , BHATT, Padmanabh
IPC分类号： A61K31/496 , A61K9/22
CPC分类号： A61K31/496 , A61K9/0004 , A61K31/506
摘要： Dosage forms and methods for the controlled release of antidepressants, such as exemplified by phenoxyethyl substituted-1, 2, 4-triazolones over a prolonged period of time are described.
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3.发明公开METHODS AND DOSAGE FORMS FOR INCREASING SOLUBILITY OF DRUG COMPOSITIONS FOR CONTROLLED DELIVERY 审中-公开方法和剂型增加药物组合物的溶解度控制的供给
公开(公告)号：EP1703894A1
公开(公告)日：2006-09-27
申请号：EP04817055.9
申请日：2004-12-22
申请人： ALZA CORPORATION
发明人： JAO, Frank , EDGREN, David , SKLUZACEK, Robert , YAM, Noymi
CPC分类号： A61K9/0004 , A61K31/7004
摘要： Dosage forms and devices for enhancing controlled delivery of pharmaceutical agents by use of a drug core composition that increases the solubility of the pharmaceutical agent are described. The present invention provides a means of delivering high doses of poorly soluble drug in oral drug delivery systems that are convenient to swallow, for once-a-day administration.
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4.发明授权DOSAGE FORMS AND METHODS FOR PROVIDING EFFECTIVE REBOXETINE THERAPY WITH ONCE-A-DAY DOSING 有权剂型和以“一天一次”剂量的方法对于一个有效的REBOXETINTHERAPIE
公开(公告)号：EP1216031B1
公开(公告)日：2007-03-14
申请号：EP00963500.4
申请日：2000-09-15
申请人： ALZA CORPORATION
发明人： SEROFF, Sylvia , YAM, Noymi , AYER, Atul, D. , BHATT, Padmanabh , DESJARDIN, Michael, A. , LAM, Andrew, C. , EDGREN, David, E. , NIXON, Phillip, R.
IPC分类号： A61K9/22
CPC分类号： A61K31/5375 , A61K9/0004
摘要： Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxetine concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma reboxetine concentration occurrence in each 24 hour period. In addition, the peak plasma reboxetine concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma reboxetine concentration that occurs following administration of reboxetine in an immediate-release dosage form.
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5.发明公开DOSAGE FORMS AND METHODS FOR PROVIDING EFFECTIVE REBOXETINE THERAPY WITH ONCE-A-DAY DOSING 有权剂型和以“一天一次”剂量的方法对于一个有效的REBOXETINTHERAPIE
公开(公告)号：EP1216031A2
公开(公告)日：2002-06-26
申请号：EP00963500.4
申请日：2000-09-15
申请人： Alza Corporation
发明人： SEROFF, Sylvia , YAM, Noymi , AYER, Atul, D. , BHATT, Padmanabh , DESJARDIN, Michael, A. , LAM, Andrew, C. , EDGREN, David, E. , NIXON, Phillip, R.
IPC分类号： A61K9/22
CPC分类号： A61K31/5375 , A61K9/0004
摘要： Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxetine concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma reboxetine concentration occurrence in each 24 hour period. In addition, the peak plasma reboxetine concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma reboxetine concentration that occurs following administration of reboxetine in an immediate-release dosage form.
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公开(公告)号：EP1126853A1
公开(公告)日：2001-08-29
申请号：EP99971322.5
申请日：1999-10-26
申请人： ALZA CORPORATION
发明人： CRUZ, Evangeline, G. , YAM, Noymi , ZHONG, Adam , AYER, Atul , BHATT, Padmanabh
IPC分类号： A61K31/496 , A61K9/22
CPC分类号： A61K31/496 , A61K9/0004 , A61K31/506
摘要： Dosage forms and methods for the controlled release of antidepressants, such as exemplified by phenoxyethyl substituted-1, 2, 4-triazolones over a prolonged period of time are described.
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公开(公告)号：EP1701708A2
公开(公告)日：2006-09-20
申请号：EP04815922.2
申请日：2004-12-28
申请人： ALZA CORPORATION
发明人： EDGREN, David , JAO, Frank , KIMBEL, Rhea , LI, Shaoling , YAM, Noymi , SEROFF, Sylvia Lillian , SHIVANAND, Padmaja
CPC分类号： A61K9/0004 , A61K9/209 , A61K31/35
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and / or low dissolution rate pharmacuetical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
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公开(公告)号：EP1701706A2
公开(公告)日：2006-09-20
申请号：EP04815919.8
申请日：2004-12-28
申请人： ALZA CORPORATION
发明人： EDGREN, David , JAO, Frank , KIMBEL, Rhea , LI, Shaoling , YAM, Noymi , SEROFF, Sylvia Lillian , SHIVANAND, Padmaja
CPC分类号： A61K9/209 , A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmacuetical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
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公开(公告)号：EP1126827A2
公开(公告)日：2001-08-29
申请号：EP99971310.0
申请日：1999-10-26
申请人： ALZA CORPORATION
IPC分类号： A61K9/24
CPC分类号： A61K9/0004
摘要： Controlled release of active agents from sustained release push delivery devices having high drug loading are described wherein residual drug content in the device is minimized by the utilization of a flow-promoting layer between the semi-permeable wall and the drug layer.
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