公开(公告)号：EP1499291B1

公开(公告)日：2009-01-07

申请号：EP03728526.9

申请日：2003-04-25

申请人： ALZA Corporation

发明人： AYER, Atul ,  SHIVANAND, Padmaja ,  MODI, Nishit, B. ,  SEROFF, Sonya ,  DESJARDIN, Michael, A. ,  FINK, Tracy, A. ,  HEARNEY, Linda, M. ,  JOHNSON, Deborah, J. ,  ALLPHIN, Clark, P.

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61P25/04

CPC分类号： A61K9/0004 ,  A61K31/485

摘要： Dosage forms and methods for the controlled release of oxycodone over a prolonged period of time are described. The sustained release dosage forms provide therapeutically effective average steady-state plasma oxycodone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma oxycodone concentration occurrence in each 24 hour period that occurs at a later time after administration and exhibits a lesser magnitude than the peak plasma oxycodone concentration that occurs following administration of oxycodone in an immediate-release dosage form and other prior art extended release dosage forms.

公开(公告)号：EP1126853A1

公开(公告)日：2001-08-29

申请号：EP99971322.5

申请日：1999-10-26

申请人： ALZA CORPORATION

发明人： CRUZ, Evangeline, G. ,  YAM, Noymi ,  ZHONG, Adam ,  AYER, Atul ,  BHATT, Padmanabh

IPC分类号： A61K31/496 ,  A61K9/22

CPC分类号： A61K31/496 ,  A61K9/0004 ,  A61K31/506

摘要： Dosage forms and methods for the controlled release of antidepressants, such as exemplified by phenoxyethyl substituted-1, 2, 4-triazolones over a prolonged period of time are described.

公开(公告)号：EP1126853B1

公开(公告)日：2006-04-19

申请号：EP99971322.5

申请日：1999-10-26

申请人： ALZA CORPORATION

发明人： CRUZ, Evangeline, G. ,  YAM, Noymi ,  ZHONG, Adam ,  AYER, Atul ,  BHATT, Padmanabh

IPC分类号： A61K31/496 ,  A61K9/22

CPC分类号： A61K31/496 ,  A61K9/0004 ,  A61K31/506

摘要： Dosage forms and methods for the controlled release of antidepressants, such as exemplified by phenoxyethyl substituted-1, 2, 4-triazolones over a prolonged period of time are described.

公开(公告)号：EP1517671A2

公开(公告)日：2005-03-30

申请号：EP03742204.5

申请日：2003-06-26

申请人： Alza Corporation

发明人： EDGREN, David ,  WONG, Patrick, S., L. ,  JAO, Frank ,  SKLUZACEK, Robert ,  LI, Shu ,  LAM, Andrew ,  BHATTI, Gurdish ,  LI, Shaoling ,  AYER, Atul ,  TO, Winnie

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K31/35 ,  A61K31/4166 ,  A61P25/08

CPC分类号： A61K31/4166 ,  A61K9/0004 ,  A61K31/35 ,  A61K47/34

摘要： Dosage forms and devices for enhancing controlled delivery of pharmaceutical agents by use of a drug core composition containing a polymer carrier (e.g. polyethylene oxide) and a surfactant (e.g. polyoxyl stearate, poloxamer) that increases the solubility of the pharmaceutical agent are described. The present invention provides a means of delivering high doses of lowly soluble drug in oral drug delivery systems that are convenient to swallow, for once-a-day administration. Osmotic devices are described.

公开(公告)号：EP1499291A1

公开(公告)日：2005-01-26

申请号：EP03728526.9

申请日：2003-04-25

申请人： Alza Corporation

发明人： AYER, Atul ,  SHIVANAND, Padmaja ,  MODI, Nishit, B. ,  SEROFF, Sonya ,  DESJARDIN, Michael, A. ,  FINK, Tracy, A. ,  HEARNEY, Linda, M. ,  JOHNSON, Deborah, J. ,  ALLPHIN, Clark, P. ,  RASHID, Ayesha

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61P25/04

CPC分类号： A61K9/0004 ,  A61K31/485

摘要： Dosage forms and methods for the controlled release of oxycodone over a prolonged period of time are described. The sustained release dosage forms provide therapeutically effective average steady-state plasma oxycodone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma oxycodone concentration occurrence in each 24 hour period that occurs at a later time after administration and exhibits a lesser magnitude than the peak plasma oxycodone concentration that occurs following administration of oxycodone in an immediate-release dosage form and other prior art extended release dosage forms.