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    APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF FENTANYL-BASED AGENTS
    1.
    发明公开
    APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF FENTANYL-BASED AGENTS 审中-公开
    用于透皮递送基于芬太尼的药剂的装置和方法

    公开(公告)号：EP1737434A2

    公开(公告)日：2007-01-03

    申请号：EP05725916.0

    申请日：2005-03-18

    申请人： ALZA CORPORATION

    发明人： AMERI, Mahmoud ,  CORMIER, Michel, J.N. ,  MAA, Yuh-Fun ,  DADDONA, Peter ,  GALE, Robert, M.

    IPC分类号： A61K9/70

    CPC分类号： A61K9/0021 ,  A61K31/445 ,  A61M37/0015 ,  A61M2037/0023

    摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the fentanyl-based agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having a fentanyl-based agent­containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the fentanyl-based agent is contained in both the coating and the hydrogel formulation.

    摘要翻译： 一种用于透皮递送生物活性剂的设备和方法，该设备和方法包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括适于刺穿角质层进入下面的表皮层的多个微突出物（或其阵列） 表皮和真皮层。 在一个实施方案中，基于芬太尼的药剂被包含在施用于微喷射体元件的生物相容涂层中。 在进一步的实施方案中，递送系统包括具有基于芬​​太尼的药剂的含水凝胶制剂的凝胶组合物，其在施用于患者皮肤之后置于微喷射体构件上。 在另一个实施方案中，基于芬太尼的试剂包含在包衣和水凝胶制剂中。

    METHOD AND DEVICE FOR COATING A CONTINUOUS STRIP OF MICROPROJECTION MEMBERS
    5.
    发明公开
    METHOD AND DEVICE FOR COATING A CONTINUOUS STRIP OF MICROPROJECTION MEMBERS 审中-公开
    方法和装置涂层的连续条带微型投影元素

    公开(公告)号：EP1898989A2

    公开(公告)日：2008-03-19

    申请号：EP06785214.5

    申请日：2006-06-20

    申请人： ALZA CORPORATION

    发明人： DADDONA, Peter ,  DOHNER, John

    IPC分类号： A61M37/00

    CPC分类号： A61B17/205 ,  A61B2017/00526 ,  A61B2017/00893 ,  A61M37/0015 ,  A61M2037/0053

    摘要： The present invention provides a device and method for selectively providing multiple applications of an agent formulation on the skin piercing portions of a micrÌprojection member to form an agent-containing coating on the microprojections. The formulation is dried to form a solid coating which contains the agent. A continuous conveyor strip bearing multiple microprojection members is spiral wrapped around a product drum so that each microprojection member is conveyed past a reservoir a plurality of times. The reservoir is configured to transfer an application of agent formulation onto the microprojection member each time it passes the reservoir.

    MICROPROJECTION APPARATUS AND SYSTEM WITH LOW INFECTION POTENTIAL
    9.
    发明公开
    MICROPROJECTION APPARATUS AND SYSTEM WITH LOW INFECTION POTENTIAL 审中-公开
    微型投影装置及系统具有低潜在感染

    公开(公告)号：EP1776156A1

    公开(公告)日：2007-04-25

    申请号：EP05786621.2

    申请日：2005-08-10

    申请人： Alza Corporation, c/o Johnson & Johnson

    发明人： CORMIER, Michel, J., N. ,  DADDONA, Peter ,  ANDERSON, Rolfe

    IPC分类号： A61M37/00 ,  A61K9/70

    CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K9/06 ,  A61M2037/0023 ,  A61M2037/0046

    摘要： A transdermal agent delivery apparatus and system having a low infection potential comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the microprojection member includes a biocompatible coating having at least one biologically active agent and at least one antimicrobial agent disposed therein. In another embodiment, the microprojection member includes a hydrogel formulation having at least one biologically active agent and at least one antimicrobial agent. In yet another embodiment, the microprojection member includes a hydrogel formulation having at least one antimicrobial agent and a solid film having at least one biologically active agent.