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1.发明公开Precursors and synthesis of methyl-9-oxo-11 alpha, 16-di-hydroxy-16-vinyl-5-cis-13-transprostadienoates 失效Vorläuferund Synthese von甲基-9-氧代-11-α，16-二羟基-16-乙烯基-5-顺式-13-转葡糖基二烯酸。
公开(公告)号：EP0266533A2
公开(公告)日：1988-05-11
申请号：EP87113814.5
申请日：1987-09-22
摘要： This disclosure describes novel compounds which are useful as precursors in the synthesis of 9-oxo-11α, 16-dihydroxy-16-vinyl-5- cis -13- trans -prostadienoate esters which possess activity as hypotensive agents and/or as vasodilators.
摘要翻译： 本公开描述了在合成作为降血压剂和/或作为血管扩张剂的活性的9-氧代-11α，16-二羟基-16-乙烯基-5-顺式-13-反 - 前列腺素酯的合成中可用作前体的新型化合物 。
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公开(公告)号：EP0470355B1
公开(公告)日：1996-06-05
申请号：EP91110587.2
申请日：1991-06-26
IPC分类号： C07H19/04
CPC分类号： C07D239/54 , C07D405/04 , C07H19/06
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3.发明公开
公开(公告)号：EP0471941A3
公开(公告)日：1992-10-14
申请号：EP91110022.0
申请日：1991-06-19
发明人： Green, Kenneth E.
摘要： This invention is concerned with an improved process for metallating 2,4,6-tribromoanisole 1 and reacting this intermediate lithio species with various electrophiles for example the trialkoxy borates which an example is trimethylborate, the improvement comprising carrying out the reaction under heterogenous conditions. This product is oxidatively converted to the compound 5-bromo-2-methoxy-resorcinol 2 , which is in turn converted to the known 2-methoxy-resorcinol 3 . The process and intermediate are useful in the synthesis of platelet activating factor antagonist thiazolium, 3-[[3-[[hydroxy[2-methoxy-3-(tetradecyloxy) phenoxy]phosphinyl]oxy]phenyl]methyl]-5-methyl-, hydroxide, inner salt CA of U. S. Patent 4983592 (1991).
摘要翻译： 本发明涉及用于金属化2,4,6-三溴苯甲醚1并使该中间体锂二氧化物与各种亲电体反应的改进方法，例如硼酸三甲酯的三烷氧基硼酸盐，其改进包括在异质条件下进行反应。 将该产物氧化转化为化合物5-溴-2-甲氧基间苯二酚2，其又转化为已知的2-甲氧基间苯二酚3.该方法和中间体可用于合成血小板活化因子拮抗剂噻唑， 3 - [[3 - [[羟基[2-甲氧基-3-（十四烷氧基）苯氧基]氧膦基]氧基]苯基]甲基] -5-甲基 - 氢氧化物，内盐CA，美国专利4983592（1991）。
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4.发明公开An improved process for the preparation of 5-bromo-2-methoxyresorcinol 失效Verbeetes Verfahren zur Herstellung von 5-溴-2-甲氧基间苯二酚。
公开(公告)号：EP0471941A2
公开(公告)日：1992-02-26
申请号：EP91110022.0
申请日：1991-06-19
发明人： Green, Kenneth E.
摘要： This invention is concerned with an improved process for metallating 2,4,6-tribromoanisole 1 and reacting this intermediate lithio species with various electrophiles for example the trialkoxy borates which an example is trimethylborate, the improvement comprising carrying out the reaction under heterogenous conditions. This product is oxidatively converted to the compound 5-bromo-2-methoxy-resorcinol 2 , which is in turn converted to the known 2-methoxy-resorcinol 3 . The process and intermediate are useful in the synthesis of platelet activating factor antagonist thiazolium, 3-[[3-[[hydroxy[2-methoxy-3-(tetradecyloxy) phenoxy]phosphinyl]oxy]phenyl]methyl]-5-methyl-, hydroxide, inner salt CA of U. S. Patent 4983592 (1991).
摘要翻译： 本发明涉及用于金属化2,4,6-三溴苯甲醚1并使该中间体锂二氧化物与各种亲电体反应的改进方法，例如硼酸三甲酯的三烷氧基硼酸盐，其改进包括在异质条件下进行反应。 将该产物氧化转化为化合物5-溴-2-甲氧基间苯二酚2，其又转化为已知的2-甲氧基间苯二酚3.该方法和中间体可用于合成血小板活化因子拮抗剂噻唑， 3 - [[3 - [[羟基[2-甲氧基-3-（十四烷氧基）苯氧基]氧膦基]氧基]苯基]甲基] -5-甲基 - 氢氧化物，内盐CA，美国专利4983592（1991）。
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5.发明公开Process for the synthesis of acetic acid, (dimethoxyphosphinyl) [[1,1-dimethylethyl)dimethylsilyl]-oxy]-,(4-nitrophenyl)methyl ester 失效1-（4-硝基苯基）甲基酯 - 一种用于生产乙酸，（二甲氧基）（（1,1-二甲基乙基）二甲基甲硅烷）处理。
公开(公告)号：EP0622371A1
公开(公告)日：1994-11-02
申请号：EP94104784.7
申请日：1994-03-25
发明人： Green, Kenneth E. , Ruso, Edward R. , Jennings, Mellard N. , Jurgens, Alex R. , Blum, David M. , Feigelson, Gregg B.
IPC分类号： C07F9/40 , C07C205/42
CPC分类号： C07C201/12 , C07F9/4006 , C07C205/42
摘要： The invention is an improved process for the large scale production of acetic acid, (dimethoxyphosphinyl) [[1,1-dimethylethyl)dimethylsilyl]oxy]-, (4-nitrophenyl)methyl ester.
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6.发明公开
公开(公告)号：EP0470355A1
公开(公告)日：1992-02-12
申请号：EP91110587.2
申请日：1991-06-26
IPC分类号： C07H19/04
CPC分类号： C07D239/54 , C07D405/04 , C07H19/06
摘要： An improved process for the preparation of 2' and 3'-(halo-substituted)-2',3'-dideoxy nucleosides by reacting a protected anhydrothymidine compound with a halogenating composition containing a substituted organoaluminum compound which exhibits greater solubility in conventional solvents than AIF 3 .
摘要翻译： 通过使受保护的脱水胸苷化合物与含有取代的有机铝化合物的卤化组合物反应制备2'和3' - （卤素取代的）-2'，3'-二脱氧核苷的改进方法， 氟化铝。
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7.发明公开Precursors and synthesis of methyl-9-oxo-11 alpha, 16-di-hydroxy-16-vinyl-5-cis-13-transprostadienoates 失效前体和甲基-9-OXO-11 ALPHA，16-二羟基-16-乙烯基-5-CIS-13-十二烷基硫酸酯的合成
公开(公告)号：EP0266533A3
公开(公告)日：1988-07-20
申请号：EP87113814
申请日：1987-09-22
IPC分类号： C07C43/32 , C07C177/00 , C07F01/08 , C07F07/22 , C07F07/18 , C07C41/60 , C07C69/732 , C07C67/307
摘要： This disclosure describes novel compounds which are useful as precursors in the synthesis of 9-oxo-11α, 16-dihydroxy-16-vinyl-5- cis -13- trans -prostadienoate esters which possess activity as hypotensive agents and/or as vasodilators.
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