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1.发明公开BENZYLLACTOBIONAMIDES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION 审中-公开平滑肌增生的BENZYLLACTOBIONAMIDE作为抑制剂
公开(公告)号：EP1133507A2
公开(公告)日：2001-09-19
申请号：EP99944107.4
申请日：1999-11-23
IPC分类号： C07H13/04 , C07H13/08 , C07H11/00 , A61K31/70 , A61P9/00 , A61P21/00 , A61P35/00 , C07H15/18
CPC分类号： C07H15/203
摘要： This invention provides smooth muscle cell proliferation inhibitors of formula (I) having the structure or a pharmaceutically acceptable salt thereof.
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2.发明公开ACYLATED BENZYLMALTOSIDES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION 审中-公开酰化BENZYLMALTOSIDE增殖肌群化抑制剂
公开(公告)号：EP1133510A2
公开(公告)日：2001-09-19
申请号：EP99973295.1
申请日：1999-11-23
IPC分类号： C07H15/203 , C07H13/04 , C07H13/08 , C07H11/00 , A61K31/76 , A61P9/00 , A61P21/00 , A61P35/00
摘要： This invention provides smooth muscle cell proliferation inhibitors of formula (I) having the structure or pharmaceutically acceptable salts thereof.
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3.发明公开ACETAL BENZYLMALTOSIDES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION 审中-公开平滑肌收缩性ACETALBENZYLMALTOSIDE ALS抑制剂增殖
公开(公告)号：EP1133509A1
公开(公告)日：2001-09-19
申请号：EP99959083.9
申请日：1999-11-23
IPC分类号： C07H15/203 , A61K31/70
CPC分类号： C07H15/203
摘要： This invention provides smooth muscle cell proliferation inhibitors of formula (I), having structure (I), wherein X, R?1, R2, R3, R4, R5, R6, R7, R8 and R9¿ have the meaning given in the claims and description.
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4.发明公开2,3,5-SUBSTITUTED BIPHENYLS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA 审中-公开2,3,5-SUBSTITUIERTE BIPHENYLENÜTZLICHIN DIE BEHANDLUNG VON INSULINRESISTENZ UNDHYPERGLYKÄMIE
公开(公告)号：EP1077929A1
公开(公告)日：2001-02-28
申请号：EP99924158.1
申请日：1999-05-10
发明人： BUTERA, John, Anthony , CAUFIELD, Craig, Eugene , GRACEFFA, Russell, Francis , GREENFIELD, Alexander , GUNDERSEN, Eric, Gould , HAVRAN, Lisa, Marie , KATZ, Alan, Howard , LENNOX, Joseph, Richard , MAYER, Scott, Christian , McDEVITT, Robert, Emmett
IPC分类号： C07C235/44 , C07C59/70 , C07D307/80 , C07F9/38 , C07F9/40 , A61K31/165 , A61K31/19
CPC分类号： C07F9/4006 , C07B2200/07 , C07C17/16 , C07C45/68 , C07C45/71 , C07C47/575 , C07C205/35 , C07C205/37 , C07C225/20 , C07C233/43 , C07C235/46 , C07C235/48 , C07C235/52 , C07C237/30 , C07C255/54 , C07C271/12 , C07C271/16 , C07C271/28 , C07C271/30 , C07C309/77 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/08 , C07D213/40 , C07D233/54 , C07D263/58 , C07D295/088 , C07D295/13 , C07D307/58 , C07D307/80 , C07D307/81 , C07D317/54 , C07D333/74 , C07D413/12 , C07C22/04
摘要： This invention provides compounds of Formula (I) having structure (I) wherein: B and D are each, independently, hydrogen, halogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, aryl, heteroaryl, aralkyl of 6-12 carbon atoms, or heteroaralkyl of 6-12 carbon atoms except where B and D both are hydrogen; R1 is hydrogen, alkyl of 1-6 carbon atoms, -SO¿2?Ph(OH)(CO2H), -CH(R?2¿)W, -CH¿2?CH2Y, or -CH2CH2CH2Y; R?2¿ is hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms, -CH¿2?(1H-imidazol-4-yl), -CH2(3-1H-indolyl), -CH2CH2(1,3-dioxo-1,3-dihydro-isoindol-2-yl), -CH2CH2(1-oxo-1,3-dihydro-isoindol-2-yl), or -CH2(3-pyridyl); W is -CO2R?3¿, -CONHOH, -CN, -CONHR3, aryl, heteroaryl, -CHO, -CH=NOR3, or -CH=NHNHR3; Y is -W, -OCH¿2CO2R?3, aryl, heteroaryl, -C(=NOH)NH¿2, -OR?3, -O(C=O)NR?4R5, -NR3(C=O)OR3, -NR3(C=O)NR4R5¿, or -NR4R5; R3 is hydrogen or alkyl of 1-6 carbon atoms; R?4 and R5¿ are each, independently, hydrogen, or alkyl of 1-6 carbon atoms or R?4 and R5¿ are, together, -(CH¿2?)n-, or -CH2CH2XCH2CH2-; X is O, S, SO, SO2, NR?3¿, or CH¿2?; n is 2 to 5; C is alkyl of 1-18 carbon atoms, aryl, heteroaryl, aralkyl of 6-20 carbon atoms, heteroaralkyl of 6-20 carbon atoms, -CONR?6R7, -NR3CONR6R7, -NR3COR6, -OR6, -O¿2CNR?6R7, -NR3CO¿2R6, -O2CR6, -CH2OR?6, -NR6R7, -CR3=CR3R8¿, -CPh¿3?, -CH2NR?6R7¿, or Formula (1); R?6 and R7¿ are each, independently, hydrogen, alkyl of 1-18 carbon atoms, aryl, heteroaryl, aralkyl of 6-20 carbon atoms, heteroaralkyl of 6-20 carbon atoms, cycloalkyl of 3-10 carbon atoms, -(CH¿2?CH2O)nCH3, -(CH2)mA or R?6 and R7¿ are, together, -(CH¿2?)p-, -(CH2)2N(CH3)(CH2)4-, -(CH2)2N(R?8)(CH¿2)2-, or -(CH2)2CH(R8)-(CH2)2-; R8 is hydrogen, alkyl of 1-18 carbon atoms, aryl, heteroaryl, aralkyl of 6-20 carbon atoms, heteroaralkyl of 6-20 carbon atoms, cycloakyl or 3-10 carbon atoms, -(CH¿2?CH2O)nCH3, -(CH2CH2CH2O)nCH3, or -(CH2)mA; A is aryl, heteroaryl, aryloxy, heteroaryloxy, arylthio, heteroarylthio, arylsulfoxy, heteroarylsulfoxy, arylsulfonyl, heteroarylsulfonyl, -CHF2, -CH2F, -CF3, -(CH2CH2O)nCH3, -(CH2CH2CH2O)nCH3, -CO2R?3¿, -O(C=O)NR6R7, aralkyloxy, or heteroaralkyloxy; m is 2 to 16; p is 2 to 12; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
摘要翻译： 本发明提供具有结构的式I化合物，其中B，C，D和R 1如本说明书中所定义，或其药学上可接受的盐，其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。
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