公开(公告)号：EP3936497A1

公开(公告)日：2022-01-12

申请号：EP21180112.1

申请日：2017-05-18

Applicant: Oregon Health & Science University

Inventor： SCANLAN, Thomas ,  DEVEREAUX, Jordan ,  PLACZEK, Andrew ,  BANERJI, Tapasree ,  FERRARA, Skylar ,  MEINIG, James Matthew ,  BANERJI, Tania

IPC: C07C37/62 ,  C07C39/27 ,  C07C41/16 ,  C07C43/29 ,  C07C45/68 ,  C07C47/565 ,  C07C51/09 ,  C07C59/70 ,  C07C67/31 ,  C07C67/343 ,  C07C69/712

Abstract: The present invention concerns a process for the preparation of compounds of Formula (I) where each R is chloro or each R is bromo.

公开(公告)号：EP2991963A2

公开(公告)日：2016-03-09

申请号：EP14719748.7

申请日：2014-04-25

Applicant: Heinrich Heine Universität Düsseldorf

Inventor： METZ, Alexander ,  GOHLKE, Holger ,  SCHANDA, Julia ,  WICHMANN, Christian ,  GREZ, Manuel

IPC: C07C59/70 ,  C07D207/337 ,  C07D209/42 ,  C07D235/28 ,  C07D307/68 ,  C07D317/60 ,  C07D471/04 ,  C07D493/04 ,  A61K31/194 ,  A61K31/341 ,  A61K31/35 ,  A61K31/36 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4184

CPC classification number: C07D471/04 ,  C07C59/68 ,  C07C59/70 ,  C07D207/337 ,  C07D209/42 ,  C07D235/28 ,  C07D239/22 ,  C07D307/68 ,  C07D317/60 ,  C07D493/04 ,  G01N27/447 ,  G01N33/5011 ,  G01N2333/47

Abstract: The invention relates to inhibitors of the NHR2 tetramerization and their use as tumor therapeutics (e.g. against acute myeloid leukemia (AML)), cytostatics, and diagnostic agents.

Abstract translation: 本发明涉及NHR2四聚化的抑制剂及其作为肿瘤治疗剂（例如抗急性骨髓性白血病（AML）），细胞抑制剂和诊断剂的用途。

公开(公告)号：EP2880978A1

公开(公告)日：2015-06-10

申请号：EP13461564.0

申请日：2013-12-09

Applicant: Przedsiebiorstwo Produkcyjno-Consultingowe ADOB sp. z o.o. sp. k.

Inventor： Nawrocki, Adam ,  Pernak, Juliusz ,  Praczyk, Tadeusz ,  Olszewski, Radoslaw ,  Niemczak, Michal

IPC: A01N39/04 ,  C07C211/63 ,  C07C215/12 ,  C07C219/06 ,  C07C219/08 ,  C07C59/70

CPC classification number: C07C211/63 ,  A01N39/04 ,  C07C59/70 ,  C07C217/28 ,  C07C219/06 ,  A01N33/12 ,  A01N37/02

Abstract: A salt represented by the Formula (1), wherein K represents a quaternary ammonium cation of the formula selected from the- group consisting of Formula (2), Formula (3), Formula (4), and Formula (5), wherein R represents an alkyl selected from the group consisting of tallow, soya and oleyl alkyla, and x and y in Formula (4) are integers from the range 1 to 15, inclusive, a herbicidal composition comprising such salt, and a method of combating undesirable plant vegetation using such salt. The salts are herbicidal ionic liquids.

Abstract translation: 由式（1）表示的盐，其中K表示选自式（2），式（3），式（4）和式（5）的式的季铵阳离子，其中R 表示选自牛油，大豆和油基烷基的烷基，式（4）中的x和y为1-15的整数，包括该组合物的除草组合物，以及一种防治不需要的植物的方法 使用这种盐的植被。 盐是除草离子液体。

公开(公告)号：EP2816023A1

公开(公告)日：2014-12-24

申请号：EP13749442.3

申请日：2013-02-12

Applicant: Takeda Pharmaceutical Company Limited

Inventor： MIWATASHI, Seiji ,  SUZUKI, Hideo ,  OKAWA, Tomohiro ,  MIYAMOTO, Yasufumi ,  YAMASAKI, Takeshi ,  HITOMI, Yuko ,  HIRATA, Yasuhiro ,  SHIBUYA, Akito

IPC: C07C59/68 ,  A61K31/192 ,  A61K31/195 ,  A61K31/351 ,  A61K31/381 ,  A61K31/4166 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/505 ,  A61K31/506 ,  A61P9/10 ,  A61P43/00 ,  C07C59/70 ,  C07C59/72 ,  C07C229/34 ,  C07C233/47 ,  C07C255/37

CPC classification number: C07C59/135 ,  C07C59/68 ,  C07C59/70 ,  C07C59/72 ,  C07C229/34 ,  C07C233/47 ,  C07C235/34 ,  C07C255/37 ,  C07C255/41 ,  C07C255/46 ,  C07C309/65 ,  C07C309/66 ,  C07C311/21 ,  C07C317/44 ,  C07C323/56 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07D213/12 ,  C07D213/30 ,  C07D213/55 ,  C07D213/64 ,  C07D213/65 ,  C07D213/68 ,  C07D213/69 ,  C07D231/12 ,  C07D239/26 ,  C07D239/34 ,  C07D271/10 ,  C07D277/24 ,  C07D285/12 ,  C07D309/06 ,  C07D333/38 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14

Abstract: Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I):

wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.

公开(公告)号：EP1999098A2

公开(公告)日：2008-12-10

申请号：EP07726688.0

申请日：2007-03-07

Applicant: High Point Pharmaceuticals, LLC

Inventor： SAUERBERG, Per

IPC: C07C59/70 ,  C07D295/096 ,  A61K31/192 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/5375 ,  A61P3/10

CPC classification number: C07C59/70 ,  C07D295/096

Abstract: Compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPAR& and should be useful for treating conditions mediated by the same.

公开(公告)号：EP1840096A4

公开(公告)日：2008-04-02

申请号：EP06711912

申请日：2006-01-18

Applicant: HOPNIC LAB CO LTD ,  DAISO CO LTD

Inventor： TAKAGI SHUNJI ,  FUJIO YOSHIHARU

IPC: B32B17/10 ,  B60J1/00 ,  C03C27/12 ,  C07C51/41 ,  C07C53/124 ,  C07C59/70 ,  C07C63/04 ,  C07C65/21 ,  C07C69/80 ,  G02B5/22

CPC classification number: B32B17/10036 ,  B32B17/10761 ,  C07C51/412 ,  C07C53/124 ,  C07C59/70 ,  C07C63/04 ,  C07C65/21 ,  C07C67/30 ,  C07C69/80 ,  G02B5/223 ,  Y10T428/31627 ,  Y10T428/3163 ,  Y10T428/31645

Abstract: [PROBLEMS] To impart an antiglare effect to a laminated glass making use of a polyvinyl butyral resin as an intermediate film without coloring the same. [MEANS FOR SOLVING PROBLEMS] There is provided an intermediate film of laminated glass, comprised of a resin composition containing a polyvinyl butyral resin, a plasticizer and a neodymium compound compatible with plasticized resin. The neodymium compound is preferably a neodymium salt containing two or more types of polyvalent ester monocarboxylic acids, or a mixed neodymium salt containing a polyvalent ester monocarboxylic acid and an aliphatic or aromatic monocarboxylic acid.

公开(公告)号：EP1756062A4

公开(公告)日：2008-01-02

申请号：EP05751010

申请日：2005-05-13

Applicant: IRM LLC

Inventor： EPPLE ROBERT ,  AZIMIOARA MIHAI

IPC: C07C59/68 ,  A61K31/19 ,  A61K31/215 ,  A61K31/47 ,  A61K45/06 ,  A61P35/00 ,  C07C53/132 ,  C07C59/70 ,  C07C69/00 ,  C07C217/76 ,  C07C255/54 ,  C07C317/22 ,  C07C323/19 ,  C07C323/20 ,  C07C323/62 ,  C07D213/28 ,  C07D213/61 ,  C07D215/00 ,  C07D215/12 ,  C07D215/14 ,  C07D239/26 ,  C07D307/40 ,  C07D307/80

CPC classification number: C07D215/14 ,  A61K31/19 ,  A61K31/215 ,  A61K31/47 ,  A61K45/06 ,  C07C59/68 ,  C07C59/70 ,  C07C217/76 ,  C07C255/54 ,  C07C317/22 ,  C07C323/19 ,  C07C323/20 ,  C07C323/62 ,  C07D213/28 ,  C07D213/61 ,  C07D215/12 ,  C07D239/26 ,  C07D307/40 ,  C07D307/80 ,  A61K2300/00

公开(公告)号：EP1840096A1

公开(公告)日：2007-10-03

申请号：EP06711912.3

申请日：2006-01-18

Applicant: Hopnic Laboratory Co., Ltd. ,  DAISO CO., LTD.

Inventor： TAKAGI, Syunji ,  FUJIO, Yoshiharu

IPC: C03C27/12 ,  B60J1/00 ,  C07C51/41 ,  C07C53/124 ,  C07C59/70 ,  C07C63/04 ,  C07C65/21 ,  C07C69/80 ,  E06B3/66

CPC classification number: B32B17/10036 ,  B32B17/10761 ,  C07C51/412 ,  C07C53/124 ,  C07C59/70 ,  C07C63/04 ,  C07C65/21 ,  C07C67/30 ,  C07C69/80 ,  G02B5/223 ,  Y10T428/31627 ,  Y10T428/3163 ,  Y10T428/31645

Abstract: [PROBLEMS] To impart an antiglare effect to a laminated glass making use of a polyvinyl butyral resin as an intermediate film without coloring the same.
[MEANS FOR SOLVING PROBLEMS] There is provided an intermediate film of laminated glass, comprised of a resin composition containing a polyvinyl butyral resin, a plasticizer and a neodymium compound compatible with plasticized resin. The neodymium compound is preferably a neodymium salt of one or more types of polyvalent ester monocarboxylic acids, or a mixed neodymium salt of a polyvalent ester monocarboxylic acid and an aliphatic or aromatic monocarboxylic acid.

Abstract translation: 为了赋予使用聚乙烯醇缩丁醛树脂作为中间膜而不使其着色的夹层玻璃赋予防眩光效果。 解决问题的手段提供一种夹层玻璃的中间膜，其由含有聚乙烯醇缩丁醛树脂，增塑剂和与增塑树脂相容的钕化合物的树脂组合物组成。 钕化合物优选为一种或多种多价酯单羧酸的钕盐，或多价酯单羧酸和脂族或芳族单羧酸的混合钕盐。

公开(公告)号：EP1838654A1

公开(公告)日：2007-10-03

申请号：EP06700691.6

申请日：2006-01-13

Applicant: Phoenix Chemicals Limited

Inventor： MCCORMACK, Peter Phoenix Chemicals Ltd. ,  CHEN, Weiping ,  MOHAMMED, Karim

IPC: C07C51/36 ,  C07C253/30 ,  C07D333/24 ,  C07C59/64 ,  C07C59/70 ,  C07C255/57

CPC classification number: C07C51/36 ,  C07B2200/07 ,  C07C253/30 ,  C07D333/24 ,  C07C59/64 ,  C07C59/68 ,  C07C255/57

Abstract: The invention concerns a process for the manufacture of substituted propionic acids comprising providing a substrate of formula (I): And subjecting the substrate to enantioselective hydrogenation under enantioselective hydrogenation conditions in the presence of an enantioselective hydrogenation catalyst comprising a catalyst ligand having a metallocene group with a chiral phosphorus or arsenic substituent to provide in enantiomeric excess a product of formula (II): or its enantiomer or if applicable its diastereomer.

公开(公告)号：EP1765760A1

公开(公告)日：2007-03-28

申请号：EP05754803.4

申请日：2005-06-21

Applicant: F.HOFFMANN-LA ROCHE AG

Inventor： ACKERMANN, Jean ,  BINGGELI, Alfred ,  GRETHER, Uwe ,  KUHN, Bernd ,  MAERKI, Hans-Peter ,  MEYER, Markus ,  AEBI, Johannes

IPC: C07C59/68 ,  C07C59/70 ,  C07D213/30 ,  C07D239/26 ,  C07C323/20 ,  C07C69/736 ,  A61P3/10 ,  A61K31/192 ,  C07C235/34

CPC classification number: C07D213/30 ,  C07C69/712 ,  C07D239/26

Abstract: This invention is concerned with compounds of the formula (I) wherein one of R5, R6 and R7 is formula (II) and X1, X2, R1 to R12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.