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1.发明公开
公开(公告)号：EP0923576A1
公开(公告)日：1999-06-23
申请号：EP97938630.0
申请日：1997-08-26
CPC分类号： C07D409/12
摘要： A compound of formula (I) in which Y is hydrogen, halogen or alkoxy; R is hydrogen or alkylthio; R1 is hydrogen or alkyl; X is hydrogen, halogen, alkoxy, alkyl or phenyl; n is one of the integers 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of shizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.
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公开(公告)号：EP1171439A1
公开(公告)日：2002-01-16
申请号：EP00923540.9
申请日：2000-04-20
IPC分类号： C07D471/04 , A61K31/437 , A61P25/24
CPC分类号： C07D471/04
摘要： Compounds useful in the treatment of diseases affected by disorders of the serotonin-affected neurological systems, such as depression and anxiety, are provided having formula (I) wherein: R1 and R2 form a carbocyclic or heterocyclic ring of 5 to 7 atoms, wherein said ring may be saturated or unsaturated; and X is independently hydrogen, cyano, carbamoyl, halogen or alkoxy; or pharmaceutically acceptable salts thereof.
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3.发明公开
公开(公告)号：EP1171434A1
公开(公告)日：2002-01-16
申请号：EP00926187.6
申请日：2000-04-20
IPC分类号： C07D401/06 , C07D401/08 , A61K31/4725 , A61P25/24
CPC分类号： C07D401/06 , C07D401/08
摘要： Compounds are provided which have formula (I) wherein: R1, R2, R3, and R4 are, independently, hydrogen, halogen, alkoxy, or carboxamide; R5 is hydrogen, halogen, CF3, CN, carbamide or alkoxy; and X is (CH2)n or a 4-6 membered carbocyclic ring, wherein n is an integer of 2 to 4; or pharmaceutically acceptable salts thereof.
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4.发明公开
公开(公告)号：EP1140919A1
公开(公告)日：2001-10-10
申请号：EP00903156.8
申请日：2000-01-06
IPC分类号： C07D409/14 , A61K31/445 , A61P25/24 , A61P25/22
CPC分类号： C07D409/14
摘要： Compounds useful for the treatment of disorders of the serotonin-affected neurological systems are provided which have formula (I) wherein: X is carbon or nitrogen; the dotted line represents an optional bond which is absent when X = N; R1 and R2 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, or MeSO2; R3 is hydrogen, halogen, or alkyl; R4 is hydrogen, alkyl, alkylaryl, or aryl; and R5 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; or a pharmaceutically acceptable salt thereof.
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5.发明公开4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A? LIGANDS 失效4-氨基乙氧基 - 吲哚衍生物ALS多巴胺D2激动剂和AS 5HT1A配体
公开(公告)号：EP0923548A1
公开(公告)日：1999-06-23
申请号：EP97938629.0
申请日：1997-08-26
CPC分类号： C07D209/30 , C07D209/08 , C07D209/12
摘要： Compounds of the formula (I) in which R1 is hydrogen, alkyl, cycloalkylalkyl, arylalkyl, (haloaryl)alkyl, (alkoxy-aryl)alkyl, thienylmethyl, furanylmethyl, pyridinylmethyl, alkylphenyl, 4-fluoro-butyrophenome or 6-fluoro-1,2-benzisoxasol-yl-propyl; X is hydrogen, halogen, cyano, alkyl, acetyl, trifluoroacetyl, trifluoromethyl or formyl; Y is hydrogen, halogen, alkoxy or alkyl; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs and they also have affinity for the 5-HT1A receptors which characterizes them as useful in the treatment of diseases attending disturbances in the serotinergic systems, such as anxiety, stress, depression, sexual dysfunctions and sleep disturbances.
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