公开(公告)号：EP1656355A2

公开(公告)日：2006-05-17

申请号：EP04820712.0

申请日：2004-06-21

申请人： AMGEN INC.

发明人： CHEN, Jian, J. ,  ASKEW, Ben, C. ,  BISWAS, Kaustav ,  CHAU, Jennifer, N. ,  D'AMICIO, Derin, C. ,  HARRIED, Scott ,  NGUYEN, Thomas ,  QIAN, Wenyuan ,  ZHU, Jiawang ,  FOTSCH, Christopher, H. ,  HAN, Nianhe ,  LI, Aiwen ,  LIU, Qingyian ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  PETERKIN, Tanya ,  RIAHI, Babak ,  YANG, Kevin ,  YUAN, Chester, Chenguang

IPC分类号： C07D241/00

CPC分类号： C07D241/08 ,  C07D243/08 ,  C07D245/02 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14

摘要： Compounds (I) are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1656355B1

公开(公告)日：2008-03-12

申请号：EP04820712.0

申请日：2004-06-21

申请人： AMGEN INC.

发明人： CHEN, Jian, J. ,  ASKEW, Ben, C. ,  BISWAS, Kaustav ,  CHAU, Jennifer, N. ,  D'AMICO, Derin, C. ,  HARRIED, Scott ,  NGUYEN, Thomas ,  QIAN, Wenyuan ,  ZHU, Jiawang ,  FOTSCH, Christopher, H. ,  HAN, Nianhe ,  LI, Aiwen ,  LIU, Qingyian ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  PETERKIN, Tanya ,  RIAHI, Babak ,  YANG, Kevin ,  YUAN, Chester, Chenguang

IPC分类号： A61K31/495 ,  C07D241/08 ,  C07D243/08 ,  C07D245/02 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC分类号： C07D241/08 ,  C07D243/08 ,  C07D245/02 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14

摘要： Compounds (I) are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1483263A1

公开(公告)日：2004-12-08

申请号：EP03711046.7

申请日：2003-02-13

申请人： Amgen Inc.

发明人： SANTORA, Vincent ,  ASKEW, Benny, C. ,  DE MORIN, Frenel, F. ,  HAGUE, Andrew ,  LABER, Ellen ,  LI, Aiwen ,  LIU, Gang ,  LOPEZ, Patricia ,  NOMAK, Rana ,  TEGLEY, Christopher ,  YANG, Kevin

IPC分类号： C07D417/14 ,  C07D471/04 ,  C07D453/02 ,  C07D417/04 ,  C07D491/10 ,  C07D277/48 ,  A61K31/47

CPC分类号： C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/06 ,  C07D471/04 ,  C07D491/10

摘要： Selected thiazolyl urea compounds of formula (VI) are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1971604A2

公开(公告)日：2008-09-24

申请号：EP06826602.2

申请日：2006-10-23

申请人： Amgen Inc.

发明人： GERMAIN, Julie ,  ASKEW, Benny, C., Jr. ,  BAUER, David ,  CHOQUETTE, Deborah ,  DIPIETRO, Lucian, V. ,  GRACEFFA, Russell ,  HARMANAGE, Jean-Christophe ,  HUANG, Qi ,  KIM, Joseph, L. ,  LA, Daniel ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  PATEL, Vinod ,  POTASHMAN, Michele ,  RIAHI, Babak ,  STORZ, Thomas ,  VAN DER PLAS, Simon ,  YANG, Kevin ,  YUAN, Chester, C.

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1631542A1

公开(公告)日：2006-03-08

申请号：EP04759403.1

申请日：2004-04-12

申请人： Amgen, Inc. ,  Array Biopharma, Inc.

发明人： GRONEBERG, Robert, D. ,  ASKEW, Ben ,  D'AMICO, Derin ,  ZHAN, James ,  TORO, Andras ,  YONGBOO, Kim ,  MARESKA, David, A. ,  HAN, Nianh ,  FOTSCH, Christopher, H. ,  LIU, Qinglan ,  RIAHI, Babak ,  YANG, Kevin ,  LI, Aiwan ,  YUAN, Chester ,  BISWAS, Kaustav ,  HARRIED, Scott ,  NGUYEN, Tom ,  QIAN, Wenyuan ,  CHEN, Jian, J. ,  NOMAK, Rana

IPC分类号： C07C311/18 ,  C07D311/68 ,  C07D295/135 ,  C07D279/00 ,  C07D409/12 ,  A61K31/34 ,  A61K31/18 ,  A61K31/33 ,  A61P29/00 ,  A61P25/04

CPC分类号： C07C311/19 ,  C07C311/13 ,  C07C311/29 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D205/04 ,  C07D207/12 ,  C07D207/16 ,  C07D207/20 ,  C07D209/14 ,  C07D209/16 ,  C07D209/40 ,  C07D209/52 ,  C07D211/38 ,  C07D211/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/70 ,  C07D213/42 ,  C07D213/56 ,  C07D213/64 ,  C07D215/38 ,  C07D215/40 ,  C07D215/42 ,  C07D217/22 ,  C07D233/54 ,  C07D239/74 ,  C07D271/08 ,  C07D277/64 ,  C07D279/02 ,  C07D285/14 ,  C07D295/125 ,  C07D295/13 ,  C07D295/135 ,  C07D307/14 ,  C07D307/28 ,  C07D307/79 ,  C07D307/81 ,  C07D311/68 ,  C07D317/58 ,  C07D333/20 ,  C07D333/24 ,  C07D333/58 ,  C07D333/62 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D407/06 ,  C07D407/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/08

摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 选择的化合物是有效的用于治疗疼痛和疾病，：如炎症介导的疾病的。 本发明包括新化合物，类似物，前体药物和药学上可接受的衍生物，药物组合物和用于预防的方法和治疗疾病和其它疾病或病症涉及疼痛，炎症等。 本主题发明因此涉及一种用于制造测试以及的中间体在寻求过程中有用的化合物的方法。

公开(公告)号：EP1971604B1

公开(公告)日：2012-08-01

申请号：EP06826602.2

申请日：2006-10-23

申请人： Amgen Inc.

发明人： GERMAIN, Julie ,  ASKEW, Benny, C., Jr. ,  BAUER, David ,  CHOQUETTE, Deborah ,  DIPIETRO, Lucian, V. ,  GRACEFFA, Russell ,  HARMANAGE, Jean-Christophe ,  HUANG, Qi ,  KIM, Joseph, L. ,  LA, Daniel ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  PATEL, Vinod ,  POTASHMAN, Michele ,  RIAHI, Babak ,  STORZ, Thomas ,  VAN DER PLAS, Simon ,  YANG, Kevin ,  YUAN, Chester, C.

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1773817B1

公开(公告)日：2009-08-26

申请号：EP05791799.9

申请日：2005-07-20

申请人： Amgen Inc.

发明人： YUAN, Chester Chenguang ,  YANG, Kevin ,  VANDERPLAS, Simon ,  RIAHI, Babak ,  POTASHMAN, Michele ,  PATEL, Vinod F. ,  NOMAK, Rana ,  LI, Aiwen ,  HUANG, Qi ,  HARMANGE, Jean-Christophe ,  ASKEW, JR., Benny C.

IPC分类号： C07D401/12 ,  C07D413/14 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D217/02 ,  C07D403/12 ,  C07D417/14 ,  C07D471/04 ,  A61K31/443 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07D217/02 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

公开(公告)号：EP1562933B1

公开(公告)日：2008-03-19

申请号：EP03764755.9

申请日：2003-07-15

申请人： AMGEN INC.

发明人： PATEL, Vinod, F. ,  ASKEW JR, Benny, C. ,  BOOKER, Shon ,  CHEN, Guoqing ,  DIPIETRO, Lucian, V. ,  GERMAIN, Julie ,  HABGOOD, Gregory, J. ,  HUANG, Qi ,  KIM, Tae-Seong ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  RIAHI, Babak ,  YUAN, Chester, Chenguang ,  ELBAUM, Daniel

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D417/14 ,  C07D405/14 ,  C07D407/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4433 ,  C07D413/14

CPC分类号： C07D471/04 ,  A61K31/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1773817A1

公开(公告)日：2007-04-18

申请号：EP05791799.9

申请日：2005-07-20

申请人： Amgen Inc.

发明人： YUAN, Chester Chenguang ,  YANG, Kevin ,  VANDERPLAS, Simon ,  RIAHI, Babak ,  POTASHMAN, Michele ,  PATEL, Vinod F. ,  NOMAK, Rana ,  LI, Aiwen ,  HUANG, Qi ,  HARMANGE, Jean-Christophe ,  ASKEW, JR., Benny C.

IPC分类号： C07D401/12 ,  C07D413/14 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D217/02 ,  C07D403/12 ,  C07D417/14 ,  C07D471/04 ,  A61K31/443 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07D217/02 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

公开(公告)号：EP1633743A1

公开(公告)日：2006-03-15

申请号：EP04759563.2

申请日：2004-04-12

申请人： Amgen, Inc. ,  Array Biopharma, Inc.

发明人： GRONEBERG, Robert, D. ,  ZHAN, James ,  ASKEW, Ben ,  D'AMICO, Derin ,  HAN, Nianh ,  FOTSCH, Christopher, H. ,  LIU, Qinglan ,  RIAHI, Babak ,  ZHU, Jiawang ,  YANG, Kevin ,  CHEN, Jian, J. ,  NOMAK, Rana

IPC分类号： C07D405/12 ,  C07D413/14 ,  C07D405/14 ,  C07D207/48 ,  C07D409/14 ,  C07D211/96 ,  C07D401/12 ,  C07D417/12 ,  C07D215/58 ,  A61P29/00 ,  C07D409/12 ,  C07D417/14 ,  C07D217/22 ,  A61K31/425 ,  A61K31/4523

CPC分类号： C07D207/48 ,  C07D211/96 ,  C07D215/58 ,  C07D217/22 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of formula (I) are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation mediated by Bradykinin. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes wherein q, t, R, Ra, Rb, Rc and R2 are as defined herein.