公开(公告)号：EP2079525A1

公开(公告)日：2009-07-22

申请号：EP07861535.8

申请日：2007-10-25

申请人： Amgen Inc.

发明人： FOTSCH, Christopher H. ,  TASKER, Andrew ,  POON, Steve, Fong ,  COULTER, Thomas, S. ,  KELLY, Michael, Gerard ,  DAVENPORT, Adams, James ,  HARRINGTON, Paul, E. ,  GHIRON, Chiara ,  ZENG, Qing, Ping ,  XI, Ning

IPC分类号： A61P1/12 ,  A61P3/14 ,  A61P5/20 ,  C07D207/06 ,  C07D207/09 ,  C07D207/48 ,  C07D211/22 ,  C07D211/62 ,  C07D213/30 ,  C07D213/38 ,  C07D213/81 ,  C07D213/82 ,  C07D231/14 ,  C07D233/60 ,  C07D235/06 ,  C07D237/14

CPC分类号： C07D261/18 ,  C07C211/29 ,  C07C217/58 ,  C07C233/43 ,  C07C233/44 ,  C07C233/80 ,  C07C271/28 ,  C07C311/37 ,  C07C317/32 ,  C07C323/32 ,  C07C2601/08 ,  C07C2601/16 ,  C07D207/06 ,  C07D207/09 ,  C07D207/48 ,  C07D211/22 ,  C07D211/62 ,  C07D213/30 ,  C07D213/38 ,  C07D213/81 ,  C07D213/82 ,  C07D231/14 ,  C07D233/60 ,  C07D235/06 ,  C07D237/14 ,  C07D239/42 ,  C07D249/08 ,  C07D261/08 ,  C07D263/24 ,  C07D263/34 ,  C07D271/06 ,  C07D285/06 ,  C07D295/088 ,  C07D295/185 ,  C07D295/205 ,  C07D295/26 ,  C07D307/68 ,  C07D317/58 ,  C07D333/38 ,  C07D333/40 ,  C07D409/04 ,  C07D413/12 ,  C07D417/04

摘要： The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.

摘要翻译： 本发明一般涉及式I所示的化合物，包含它们的药物组合物以及治疗与钙敏感受体的功能有关的疾病或病症的方法。 本发明还涉及制备这些化合物的方法和在这些方法中有用的中间体。

公开(公告)号：EP1751136A2

公开(公告)日：2007-02-14

申请号：EP05779977.7

申请日：2005-05-09

申请人： AMGEN INC.

发明人： GEUNS-MEYER, Stephanie, D. ,  HODOUS, Brian, L. ,  CHAFFEE, Stuart, C. ,  TEMPEST, Paul, A. ,  OLIVIERI, Philip, R. ,  JOHNSON, Rebecca, E. ,  ALBRECHT, Brian, K. ,  PATEL, Vinod, F. ,  CEE, Victor, J. ,  KIM, Joseph, L. ,  BELLON, Steven ,  ZHU, Xiaotian ,  CHENG, Yuan ,  XI, Ning ,  ROMERO, Karina ,  NGUYEN, Hanh, Nho ,  DEAK, Holly, L.

IPC分类号： C07D401/04

CPC分类号： C07D213/73 ,  C07D239/42 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04

摘要： The present invention relates to chemical compounds having a general formula (I) wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.

公开(公告)号：EP1603905A1

公开(公告)日：2005-12-14

申请号：EP04709532.8

申请日：2004-02-09

申请人： AMGEN INC.

发明人： DOHERTY, Elizabeth, M. ,  HAN, Nianhe ,  HUNGATE, Randall, W. ,  LIU, Qingyian ,  NORMAN, Mark, H. ,  XI, Ning ,  XU, Shimin ,  FOTSCH, Christopher, H.

IPC分类号： C07D417/04 ,  C07D417/12 ,  C07D403/04 ,  C07D277/20 ,  C07D233/66 ,  C07D263/34 ,  A61P29/00

CPC分类号： C07D233/90 ,  C07D263/34 ,  C07D277/56 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

公开(公告)号：EP1467721A2

公开(公告)日：2004-10-20

申请号：EP02723086.1

申请日：2002-01-11

申请人： Amgen Inc.

发明人： CHEN, Guoqing ,  ADAMS, Jeffrey ,  BEMIS, Jean ,  CROGHAN, Michael ,  DIPIETRO, Lucian ,  DOMINGUEZ, Celia ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  HUANG, Qi ,  KIM, Joseph, L. ,  OUYANG, Xiaohu ,  PATEL, Vinod, F. ,  SMITH, Leon, M. ,  TASKER, Andrew ,  XI, Ning ,  XU, Shimin ,  YUAN, Chester, Chenguang ,  KIM, Tae-Seong

IPC分类号： A61K31/00 ,  A61P19/02 ,  A61P35/00 ,  C07D231/56 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04

CPC分类号： C07D401/14 ,  A61K31/00 ,  C07D401/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  Y02A50/401

摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP2183232B1

公开(公告)日：2013-03-06

申请号：EP08794970.7

申请日：2008-08-01

申请人： Amgen, Inc

发明人： BOOKER, Shon ,  D'ANGELO, Noel ,  D'AMICO, Derin C. ,  KIM, Tae-seong ,  LIU, Longbin ,  MEAGHER, Kristin ,  NORMAN, Mark H. ,  PANTER, Kathleen ,  SCHENKEL, Laurie B. ,  SMITH, Adrian L. ,  TAMAYO, Nuria A. ,  WHITTINGTON, Douglas A. ,  XI, Ning ,  YANG, Kevin

IPC分类号： C07D277/82 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D513/04 ,  A61K31/423 ,  A61K31/424 ,  A61K31/428 ,  A61K31/429 ,  A61P35/00

CPC分类号： C07D277/82 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D513/04

公开(公告)号：EP1416933B8

公开(公告)日：2008-08-27

申请号：EP02750299.6

申请日：2002-07-25

申请人： Amgen Inc.

发明人： FOTSCH, Christopher, H. ,  CROGHAN, Michael ,  DOHERTY, Elizabeth, M. ,  KELLY, Michael, G. ,  NORMAN, Mark, H. ,  SMITH,Duncan, M. ,  TAMAYO, Nuria ,  XI, Ning ,  XU, Shimin

IPC分类号： A61K31/445 ,  C07D211/28 ,  C07K5/078 ,  A61P3/04 ,  C07D401/12 ,  C07D211/34 ,  C07D401/14

CPC分类号： C07K5/06191 ,  A61K38/00 ,  C07D211/28 ,  C07D211/34 ,  C07D401/12 ,  C07D401/14 ,  C07K5/06139

公开(公告)号：EP1827434A2

公开(公告)日：2007-09-05

申请号：EP05848812.3

申请日：2005-11-29

申请人： Amgen Inc.

发明人： KIM, Tae-seong ,  BELLON, Steven ,  BOOKER, Shon ,  D'ANGELO, Noel ,  DOMINGUEZ, Celia ,  FELLOWS, Ingrid ,  LEE, Matthew ,  LIU, Longbin ,  RAINBEAU, Elizabeth ,  SIEGMUND, Aaron, C. ,  TASKER, Andrew ,  XI, Ning ,  CHENG, Yuan

IPC分类号： A61K31/4709 ,  C07D401/12 ,  C07D401/14 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D215/233 ,  C07D401/12 ,  C07D409/14 ,  C07D413/12

摘要： Selected compounds of Formula (I) are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases such as cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. R - X - W - A - Y - R Formula (I) wherein R is X is O, S, NR2 or CR3R4 W is an substituted or unsubstituted aryl or substituted or unsubstituted 5- or 6- membered heteroaryl.

公开(公告)号：EP1509518A1

公开(公告)日：2005-03-02

申请号：EP03736701.8

申请日：2003-05-23

申请人： Amgen, Inc.

发明人： KELLY, Michael, G. ,  XU, Shimin ,  XI, Ning ,  TOWNSEND, Robert ,  SEMIN, David, J. ,  GHIRON, Chiara ,  COUTLER, Thomas

IPC分类号： C07D413/04 ,  C07D491/04 ,  C07D471/04 ,  C07D403/04 ,  C07D401/04 ,  C07D249/18 ,  C07D235/08 ,  C07D209/86 ,  C07D209/80 ,  C07D209/12 ,  C07D209/10 ,  C07D209/08

CPC分类号： C07D235/06 ,  C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/86 ,  C07D209/88 ,  C07D249/04 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D471/04 ,  C07D491/04

摘要： The compounds of the invention are represented by the following general structure (I) or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or inhibit PTH secretion, including methods for reducing or inhibiting PTH secretion and methods for treatment or prophylaxis of diseases associated with bone disorders, such as osteoporosis, or associated with excessive secretion of PTH, such as hyperparathyroidism. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1358184A1

公开(公告)日：2003-11-05

申请号：EP02717325.1

申请日：2002-01-11

申请人： Amgen Inc.

发明人： CHEN, Guoqing ,  ADAMS, Jeffrey ,  BEMIS, Jean ,  BOOKER, Shon ,  CAI, Guolin ,  CROGHAN, Michael ,  DIPIETRO, Lucian ,  DOMINGUEZ, Celia ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  GEUNS-MEYER, Stephanie ,  HANDLEY, Michael ,  HUANG, Qi ,  KIM, Joseph, L. ,  KIM, Tae-Seong ,  KISELYOV, Alexander ,  OUYANG, Xiaohu ,  PATEL, Vinod, F. ,  SMITH, Leon, M. ,  STEC, Markian ,  TASKER, Andrew ,  XI, Ning ,  XU, Shimin ,  YUAN, Chester Chenguang

IPC分类号： C07D409/12 ,  C07D409/14 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/14 ,  C07D405/14 ,  C07D405/12

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP2081931B1

公开(公告)日：2016-08-31

申请号：EP07810473.4

申请日：2007-07-13

申请人： Amgen Inc.

发明人： ALBRECHT, Brian ,  BAUER, David ,  BELLON, Steven ,  BODE, Christiane ,  BOOKER, Shon ,  BOEZIO, Alessandro ,  CHOQUETTE, Deborah ,  D'AMICO, Derin ,  HARMANGE, Jean-Christophe ,  HIRAI, Satoko ,  HUNGATE, Randall ,  KIM, Tae-Seong ,  LEWIS, Richard ,  LIU, Longbin ,  LOHMAN, Julia ,  NORMAN, Mark ,  POTASHMAN, Michele ,  SIEGMUND, Aaron ,  SPRINGER, Stephanie ,  STEC, Markian ,  XI, Ning ,  YANG, Kevin

IPC分类号： C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  A61K31/5025 ,  A61K31/52 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04