公开(公告)号：EP1309589B1

公开(公告)日：2006-03-15

申请号：EP01964009.3

申请日：2001-08-15

申请人： AMGEN INC.

发明人： SANTORA, Vincent ,  ASKEW, Benny ,  GHOSE, Arup ,  HAGUE, Andrew ,  KIM, Tae, Seong ,  LABER, Ellen ,  LI, Aiwen ,  LIAN, Brian ,  LIU, Gang ,  NORMAN, Mark, Henry ,  SMITH, Leon ,  TASKER, Andrew ,  TEGLEY, Christopher ,  YANG, Kevin

IPC分类号： C07D417/14

CPC分类号： C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1309589A2

公开(公告)日：2003-05-14

申请号：EP01964009.3

申请日：2001-08-15

申请人： Amgen Inc.

发明人： SANTORA, Vincent ,  ASKEW, Benny ,  GHOSE, Arup ,  HAGUE, Andrew ,  KIM, Tae, Seong ,  LABER, Ellen ,  LI, Aiwen ,  LIAN, Brian ,  LIU, Gang ,  NORMAN, Mark, Henry ,  SMITH, Leon ,  TASKER, Andrew ,  TEGLEY, Christopher ,  YANG, Kevin

IPC分类号： C07D417/14

CPC分类号： C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.