公开(公告)号：EP1664023A1

公开(公告)日：2006-06-07

申请号：EP04782276.2

申请日：2004-08-25

申请人： AMGEN INC.

发明人： TEGLEY, Christopher

IPC分类号： C07D401/12 ,  C07D471/04 ,  C07D487/04 ,  C07D401/14 ,  C07D409/14 ,  C07D217/24 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/4704 ,  A61K31/498 ,  A61K31/4985

CPC分类号： C04B35/632 ,  C07D217/24 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D471/04 ,  C07D487/04

摘要： Compounds of formula (I) are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1483263A1

公开(公告)日：2004-12-08

申请号：EP03711046.7

申请日：2003-02-13

申请人： Amgen Inc.

发明人： SANTORA, Vincent ,  ASKEW, Benny, C. ,  DE MORIN, Frenel, F. ,  HAGUE, Andrew ,  LABER, Ellen ,  LI, Aiwen ,  LIU, Gang ,  LOPEZ, Patricia ,  NOMAK, Rana ,  TEGLEY, Christopher ,  YANG, Kevin

IPC分类号： C07D417/14 ,  C07D471/04 ,  C07D453/02 ,  C07D417/04 ,  C07D491/10 ,  C07D277/48 ,  A61K31/47

CPC分类号： C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/06 ,  C07D471/04 ,  C07D491/10

摘要： Selected thiazolyl urea compounds of formula (VI) are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1664023B1

公开(公告)日：2008-08-13

申请号：EP04782276.2

申请日：2004-08-25

申请人： AMGEN INC.

发明人： TEGLEY, Christopher

IPC分类号： C07D401/12 ,  C07D471/04 ,  C07D487/04 ,  C07D401/14 ,  C07D409/14 ,  C07D217/24 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/4704 ,  A61K31/498 ,  A61K31/4985

CPC分类号： C04B35/632 ,  C07D217/24 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D471/04 ,  C07D487/04

摘要： Compounds of formula (I) are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1951696A2

公开(公告)日：2008-08-06

申请号：EP06844335.7

申请日：2006-11-13

申请人： Amgen Inc. ,  BIOVITRUM AB

发明人： HENRIKSSON, Martin ,  HOMAN, Evert ,  JOHANSSON, Lars ,  VALLGARDA, Jerk ,  WILLIAMS, Meredith ,  BERCOT, Eric, A. ,  FOTSCH, Christopher, H. ,  LI, Aiwen ,  CAI, Guolin ,  HUNGATE, Randall, W. ,  YUAN, Chester, Chenguang ,  TEGLEY, Christopher ,  ST. JEAN, David, J., Jr. ,  HAN, Nianhe ,  HUANG, Qi ,  LIU, Qingyian ,  BARTBEGER, Michael, D. ,  MONIZ, George, A. ,  FRIZZLE, Matthew, J. ,  MARSHALL, Teresa, L.

IPC分类号： C07D277/54 ,  C07D277/60 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  A61K31/426 ,  A61K31/427

CPC分类号： C07D277/54 ,  C07D277/60 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to thiazolinones and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11- β-hydroxysteroid dehydrogenase type 1 enzyme.

公开(公告)号：EP1309589B1

公开(公告)日：2006-03-15

申请号：EP01964009.3

申请日：2001-08-15

申请人： AMGEN INC.

发明人： SANTORA, Vincent ,  ASKEW, Benny ,  GHOSE, Arup ,  HAGUE, Andrew ,  KIM, Tae, Seong ,  LABER, Ellen ,  LI, Aiwen ,  LIAN, Brian ,  LIU, Gang ,  NORMAN, Mark, Henry ,  SMITH, Leon ,  TASKER, Andrew ,  TEGLEY, Christopher ,  YANG, Kevin

IPC分类号： C07D417/14

CPC分类号： C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1575947A1

公开(公告)日：2005-09-21

申请号：EP03800245.7

申请日：2003-12-22

申请人： AMGEN INC.

发明人： ZHONG, Wenge ,  NORMAN, Mark, Henry ,  KALLER, Matthew ,  NGUYEN, Thomas ,  RZASA, Robert, Michael ,  TEGLEY, Christopher ,  WANG, Hui-Ling

IPC分类号： C07D417/14 ,  C07D417/04 ,  C07D471/04 ,  C07D491/04 ,  A61K31/4412 ,  A61P35/00

CPC分类号： C07D417/14 ,  C07D417/04 ,  C07D471/04 ,  C07D491/04

摘要： Compounds of formula I are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involvong stroke, cancer and the like.

公开(公告)号：EP1664027B1

公开(公告)日：2009-12-30

申请号：EP04782152.5

申请日：2004-08-25

申请人： AMGEN INC.

发明人： TEGLEY, Christopher ,  ADAMS, Jeffrey, A. ,  ASKEW, Benny, C., Jr. ,  CROGHAN, Michael ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  HABGOOD, Gregory, J. ,  HARRIED, Scott ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana Bogazici University ,  TASKER, Andrew ,  YANG, Kevin

IPC分类号： C07D401/12 ,  C07D401/14 ,  A61K31/4427 ,  A61K31/4035 ,  A61K31/47 ,  A61P29/00 ,  A61P35/00

CPC分类号： C04B35/632 ,  C07D401/12 ,  C07D401/14

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1664027A1

公开(公告)日：2006-06-07

申请号：EP04782152.5

申请日：2004-08-25

申请人： AMGEN INC.

发明人： TEGLEY, Christopher ,  ADAMS, Jeffrey, A. ,  ASKEW, Benny, C., Jr. ,  CROGHAN, Michael ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  HABGOOD, Gregory, J. ,  HARRIED, Scott ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana Bogazici University ,  TASKER, Andrew ,  YANG, Kevin

IPC分类号： C07D401/12 ,  C07D401/14 ,  A61K31/4427 ,  A61K31/4035 ,  A61K31/47 ,  A61P29/00 ,  A61P35/00

CPC分类号： C04B35/632 ,  C07D401/12 ,  C07D401/14

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1309589A2

公开(公告)日：2003-05-14

申请号：EP01964009.3

申请日：2001-08-15

申请人： Amgen Inc.

发明人： SANTORA, Vincent ,  ASKEW, Benny ,  GHOSE, Arup ,  HAGUE, Andrew ,  KIM, Tae, Seong ,  LABER, Ellen ,  LI, Aiwen ,  LIAN, Brian ,  LIU, Gang ,  NORMAN, Mark, Henry ,  SMITH, Leon ,  TASKER, Andrew ,  TEGLEY, Christopher ,  YANG, Kevin

IPC分类号： C07D417/14

CPC分类号： C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.