公开(公告)号：EP1802586B1

公开(公告)日：2013-04-24

申请号：EP05812237.5

申请日：2005-10-17

申请人： Amgen Inc.

发明人： CHAFFEE, Stuart C. ,  ALBRECHT, Brian K. ,  HODOUS, Brian L. ,  MARTIN, Matthew W. ,  MCGOWAN, David C. ,  DIMAURO, Erin F. ,  REDDY, Gade ,  CEE, Victor J. ,  OLIVIERI, Philip R. ,  REED, Anthony ,  ROMERO, Karina

IPC分类号： C07D239/42 ,  A61K31/505 ,  A61P35/00

CPC分类号： C07D213/74 ,  C07D213/81 ,  C07D215/14 ,  C07D239/42 ,  C07D241/42 ,  C07D401/06 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D405/06 ,  C07D409/06 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

公开(公告)号：EP1836174B1

公开(公告)日：2013-02-27

申请号：EP05818381.5

申请日：2005-10-03

申请人： AMGEN INC.

发明人： PATEL, Vinod F. ,  KIM, Joseph L. ,  GEUNS-MEYER, Stephanie D. ,  CHAFFEE, Stuart C. ,  CEE, Victor J. ,  HODOUS, Brian L. ,  BELLON, Steven ,  HARMANGE, Jean-christophe ,  OLIVIERI, Philip R. ,  THAMAN, Maya C. ,  DIMAURO, Erin F. ,  BUCHANAN, John L. ,  MCGOWAN, David C. ,  ALBRECHT, Brian K. ,  DEAK, Holly L. ,  BEMIS, Jean E. ,  WHITE, Ryan ,  MARTIN, Matthew W. ,  HABGOOD, Gregory J. ,  MASSE, Craig E. ,  BUCKNER, William H. ,  TEMPEST, Paul A. ,  HERBERICH, Bradley J. ,  GRACEFFA, Russell ,  ZHANG, Dawei ,  XU, Shimin ,  SHAM, Kelvin ,  RZASA, Robert M. ,  FALSEY, James Richard ,  CHAKRABARTI, Partha P. ,  CAO, Guo-giang ,  TOMLINSON, Susan Ann ,  PETTUS, Liping H. ,  SMITH, Adrian Leonard ,  PARAS, Nick A. ,  LIU, Gang ,  DEMORIN, Frenel F. ,  TASKER, Andrew ,  REED, Anthony

IPC分类号： C07D239/84

CPC分类号： C07D215/38 ,  C07C205/37 ,  C07D215/12 ,  C07D217/12 ,  C07D217/22 ,  C07D217/26 ,  C07D239/26 ,  C07D239/84 ,  C07D239/94 ,  C07D239/95 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A 1 , A 2 , A 3 , B, R 1 , R 2 , R 3 and R 4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.

公开(公告)号：EP1994030A1

公开(公告)日：2008-11-26

申请号：EP07751460.2

申请日：2007-02-22

申请人： Amgen Inc.

发明人： CEE, Victor, J. ,  DEAK, Holly, L. ,  GEUNS-MEYER, Stephanie, D. ,  HODOUS, Brian, L. ,  NGUYEN, Hanh Nho ,  OLIVIERI, Philip R. ,  PATEL, Vinod, F. ,  ROMERO, Karina

IPC分类号： C07D401/14 ,  C07D417/14 ,  C07D413/14 ,  C07D403/12 ,  A61K31/444 ,  A61K31/4427 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention relates to chemical compounds having a general formula I 'INSERT STRUCTURE HERE' wherein A, B, C1, C2, D, L1, L2 and R3-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Tie-2 and Aurora kinase enzymes thereby influencing angiogenesis and the process of cell cycle and cell proliferation, respectively, to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of various protein kinases.

公开(公告)号：EP1984353A1

公开(公告)日：2008-10-29

申请号：EP07716912.6

申请日：2007-01-22

申请人： Amgen, Inc

发明人： CEE, Victor J. ,  DEAK, Holly L. ,  DU, Bingfan ,  GEUNS-MEYER, Stephanie D. ,  HODOUS, Brian L. ,  NGUYEN, Hanh Nho ,  OLIVIERI, Philip R. ,  PATEL, Vinod F. ,  ROMERO, Karina ,  SCHENKEL, Laurie

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D497/04 ,  A61K31/502 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D497/04

摘要： The present invention relates to chemical compounds having a general formula (I) wherein A1, A2, C1, C2, D, L1, L2, Z and R1-8 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

公开(公告)号：EP1802586A2

公开(公告)日：2007-07-04

申请号：EP05812237.5

申请日：2005-10-17

申请人： Amgen Inc.

发明人： CHAFFEE, Stuart C. ,  ALBRECHT, Brian K. ,  HODOUS, Brian L. ,  MARTIN, Matthew W. ,  MCGOWAN, David C. ,  DIMAURO, Erin F. ,  REDDY, Gade ,  CEE, Victor J. ,  OLIVIERI, Philip R. ,  REED, Anthony ,  ROMERO, Karina

IPC分类号： C07D239/42 ,  A61K31/505 ,  A61P35/00

CPC分类号： C07D213/74 ,  C07D213/81 ,  C07D215/14 ,  C07D239/42 ,  C07D241/42 ,  C07D401/06 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D405/06 ,  C07D409/06 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I: wherein A1, A2, A3, A4, R1 and R2 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.

公开(公告)号：EP1836174B2

公开(公告)日：2019-10-02

申请号：EP05818381.5

申请日：2005-10-03

申请人： AMGEN INC.

发明人： PATEL, Vinod F. ,  KIM, Joseph L. ,  GEUNS-MEYER, Stephanie D. ,  CHAFFEE, Stuart C. ,  CEE, Victor J. ,  HODOUS, Brian L. ,  BELLON, Steven ,  HARMANGE, Jean-christophe ,  OLIVIERI, Philip R. ,  THAMAN, Maya C. ,  DIMAURO, Erin F. ,  BUCHANAN, John L. ,  MCGOWAN, David C. ,  ALBRECHT, Brian K. ,  DEAK, Holly L. ,  BEMIS, Jean E. ,  WHITE, Ryan ,  MARTIN, Matthew W. ,  HABGOOD, Gregory J. ,  MASSE, Craig E. ,  BUCKNER, William H. ,  TEMPEST, Paul A. ,  HERBERICH, Bradley J. ,  GRACEFFA, Russell ,  ZHANG, Dawei ,  XU, Shimin ,  SHAM, Kelvin ,  RZASA, Robert M. ,  FALSEY, James Richard ,  CHAKRABARTI, Partha P. ,  CAO, Guo-giang ,  TOMLINSON, Susan Ann ,  PETTUS, Liping H. ,  SMITH, Adrian Leonard ,  PARAS, Nick A. ,  LIU, Gang ,  DEMORIN, Frenel F. ,  TASKER, Andrew ,  REED, Anthony

IPC分类号： C07D239/84

公开(公告)号：EP1984353B1

公开(公告)日：2015-12-30

申请号：EP07716912.6

申请日：2007-01-22

申请人： Amgen, Inc

发明人： CEE, Victor J. ,  DEAK, Holly L. ,  DU, Bingfan ,  GEUNS-MEYER, Stephanie D. ,  HODOUS, Brian L. ,  NGUYEN, Hanh Nho ,  OLIVIERI, Philip R. ,  PATEL, Vinod F. ,  ROMERO, Karina ,  SCHENKEL, Laurie

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D497/04 ,  A61K31/502 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D497/04

公开(公告)号：EP1994030B1

公开(公告)日：2010-08-25

申请号：EP07751460.2

申请日：2007-02-22

申请人： Amgen Inc.

发明人： CEE, Victor, J. ,  DEAK, Holly, L. ,  GEUNS-MEYER, Stephanie, D. ,  HODOUS, Brian, L. ,  NGUYEN, Hanh Nho ,  OLIVIERI, Philip R. ,  PATEL, Vinod, F. ,  ROMERO, Karina

IPC分类号： C07D401/14 ,  C07D417/14 ,  C07D413/14 ,  C07D403/12 ,  A61K31/444 ,  A61K31/4427 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention relates to chemical compounds having a general formula I 'INSERT STRUCTURE HERE' wherein A, B, C1, C2, D, L1, L2 and R3-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Tie-2 and Aurora kinase enzymes thereby influencing angiogenesis and the process of cell cycle and cell proliferation, respectively, to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of various protein kinases.

公开(公告)号：EP1836174A2

公开(公告)日：2007-09-26

申请号：EP05818381.5

申请日：2005-10-03

申请人： AMGEN INC.

发明人： PATEL, Vinod F. ,  KIM, Joseph L. ,  GEUNS-MEYER, Stephanie D. ,  CHAFFEE, Stuart C. ,  CEE, Victor J. ,  HODOUS, Brian L. ,  BELLON, Steven ,  HARMANGE, Jean-christophe ,  OLIVIERI, Philip R. ,  THAMAN, Maya C. ,  DIMAURO, Erin F. ,  BUCHANAN, John L. ,  MCGOWAN, David C. ,  ALBRECHT, Brian K. ,  DEAK, Holly L. ,  BEMIS, Jean E. ,  WHITE, Ryan ,  MARTIN, Matthew W. ,  HABGOOD, Gregory J. ,  MASSE, Craig E. ,  BUCKNER, William H. ,  TEMPEST, Paul A. ,  HERBERICH, Bradley J. ,  GRACEFFA, Russell ,  ZHANG, Dawei ,  XU, Shimin ,  SHAM, Kelvin ,  RZASA, Robert M. ,  FALSEY, James Richard ,  CHAKRABARTI, Partha P. ,  CAO, Guo-giang ,  TOMLINSON, Susan Ann ,  PETTUS, Liping H. ,  SMITH, Adrian Leonard ,  PARAS, Nick A. ,  LIU, Gang ,  DEMORIN, Frenel F. ,  TASKER, Andrew ,  REED, Anthony

IPC分类号： C07D239/84

CPC分类号： C07D215/38 ,  C07C205/37 ,  C07D215/12 ,  C07D217/12 ,  C07D217/22 ,  C07D217/26 ,  C07D239/26 ,  C07D239/84 ,  C07D239/94 ,  C07D239/95 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I, wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.