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公开(公告)号：EP2307400B1
公开(公告)日：2014-04-23
申请号：EP09767432.9
申请日：2009-05-29
申请人： Amgen, Inc
发明人： BO, Yunxin Y. , BOOKER, Shon , BRYAN, Marian , DEAK, Holly L. , LIU, Longbin , ANDREWS, Kristin , NISHIMURA, Nobuko , NORMAN, Mark H. , PANTER, Kathleen , SCHENKEL, Laurie , SIEGMUND, Aaron C. , TAMAYO, Nuria A. , YANG, Kevin
IPC分类号： C07D401/04 , C07D401/14 , C07D471/04 , A61K31/498 , A61K31/502 , A61K31/4709 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
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2.发明授权ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS 有权ARYLNITROGENHALTIGE双环化合物及其作为激酶抑制剂
公开(公告)号：EP1836174B1
公开(公告)日：2013-02-27
申请号：EP05818381.5
申请日：2005-10-03
申请人： AMGEN INC.
发明人： PATEL, Vinod F. , KIM, Joseph L. , GEUNS-MEYER, Stephanie D. , CHAFFEE, Stuart C. , CEE, Victor J. , HODOUS, Brian L. , BELLON, Steven , HARMANGE, Jean-christophe , OLIVIERI, Philip R. , THAMAN, Maya C. , DIMAURO, Erin F. , BUCHANAN, John L. , MCGOWAN, David C. , ALBRECHT, Brian K. , DEAK, Holly L. , BEMIS, Jean E. , WHITE, Ryan , MARTIN, Matthew W. , HABGOOD, Gregory J. , MASSE, Craig E. , BUCKNER, William H. , TEMPEST, Paul A. , HERBERICH, Bradley J. , GRACEFFA, Russell , ZHANG, Dawei , XU, Shimin , SHAM, Kelvin , RZASA, Robert M. , FALSEY, James Richard , CHAKRABARTI, Partha P. , CAO, Guo-giang , TOMLINSON, Susan Ann , PETTUS, Liping H. , SMITH, Adrian Leonard , PARAS, Nick A. , LIU, Gang , DEMORIN, Frenel F. , TASKER, Andrew , REED, Anthony
IPC分类号： C07D239/84
CPC分类号： C07D215/38 , C07C205/37 , C07D215/12 , C07D217/12 , C07D217/22 , C07D217/26 , C07D239/26 , C07D239/84 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A 1 , A 2 , A 3 , B, R 1 , R 2 , R 3 and R 4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
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公开(公告)号：EP1984353A1
公开(公告)日：2008-10-29
申请号：EP07716912.6
申请日：2007-01-22
申请人： Amgen, Inc
发明人： CEE, Victor J. , DEAK, Holly L. , DU, Bingfan , GEUNS-MEYER, Stephanie D. , HODOUS, Brian L. , NGUYEN, Hanh Nho , OLIVIERI, Philip R. , PATEL, Vinod F. , ROMERO, Karina , SCHENKEL, Laurie
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D497/04 , A61K31/502 , A61P35/00
CPC分类号： C07D401/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D497/04
摘要： The present invention relates to chemical compounds having a general formula (I) wherein A1, A2, C1, C2, D, L1, L2, Z and R1-8 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
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公开(公告)号：EP2321298A2
公开(公告)日：2011-05-18
申请号：EP09740559.1
申请日：2009-08-04
申请人： Amgen Inc.
IPC分类号： C07D401/12 , C07D403/12 , C07D403/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to chemical compounds having a general formula I (I) wherein A
1-6 , L
1 , R
1 , R
4-6 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinase proteins. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds and methods of treating disease states related to the activity of Aurora kinase.-
公开(公告)号：EP2307400A2
公开(公告)日：2011-04-13
申请号：EP09767432.9
申请日：2009-05-29
申请人： Amgen, Inc
发明人： BO, Yunxin Y. , BOOKER, Shon , BRYAN, Marian , DEAK, Holly L. , LIU, Longbin , ANDREWS, Kristin , NISHIMURA, Nobuko , NORMAN, Mark H. , PANTER, Kathleen , SCHENKEL, Laurie , SIEGMUND, Aaron C. , TAMAYO, Nuria A. , YANG, Kevin
IPC分类号： C07D401/04 , C07D401/14 , C07D471/04 , A61K31/498 , A61K31/502 , A61K31/4709 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X
1 , X
2 , R
1 and Z are as defined herein.-
公开(公告)号：EP1836174B2
公开(公告)日：2019-10-02
申请号：EP05818381.5
申请日：2005-10-03
申请人： AMGEN INC.
发明人： PATEL, Vinod F. , KIM, Joseph L. , GEUNS-MEYER, Stephanie D. , CHAFFEE, Stuart C. , CEE, Victor J. , HODOUS, Brian L. , BELLON, Steven , HARMANGE, Jean-christophe , OLIVIERI, Philip R. , THAMAN, Maya C. , DIMAURO, Erin F. , BUCHANAN, John L. , MCGOWAN, David C. , ALBRECHT, Brian K. , DEAK, Holly L. , BEMIS, Jean E. , WHITE, Ryan , MARTIN, Matthew W. , HABGOOD, Gregory J. , MASSE, Craig E. , BUCKNER, William H. , TEMPEST, Paul A. , HERBERICH, Bradley J. , GRACEFFA, Russell , ZHANG, Dawei , XU, Shimin , SHAM, Kelvin , RZASA, Robert M. , FALSEY, James Richard , CHAKRABARTI, Partha P. , CAO, Guo-giang , TOMLINSON, Susan Ann , PETTUS, Liping H. , SMITH, Adrian Leonard , PARAS, Nick A. , LIU, Gang , DEMORIN, Frenel F. , TASKER, Andrew , REED, Anthony
IPC分类号： C07D239/84
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公开(公告)号：EP1984353B1
公开(公告)日：2015-12-30
申请号：EP07716912.6
申请日：2007-01-22
申请人： Amgen, Inc
发明人： CEE, Victor J. , DEAK, Holly L. , DU, Bingfan , GEUNS-MEYER, Stephanie D. , HODOUS, Brian L. , NGUYEN, Hanh Nho , OLIVIERI, Philip R. , PATEL, Vinod F. , ROMERO, Karina , SCHENKEL, Laurie
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D497/04 , A61K31/502 , A61P35/00
CPC分类号： C07D401/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D497/04
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公开(公告)号：EP2321298B1
公开(公告)日：2013-10-02
申请号：EP09740559.1
申请日：2009-08-04
申请人： Amgen Inc.
IPC分类号： C07D401/12 , C07D403/12 , C07D403/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
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9.发明公开ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS 有权ARYLNITROGENHALTIGE双环化合物及其作为激酶抑制剂
公开(公告)号：EP1836174A2
公开(公告)日：2007-09-26
申请号：EP05818381.5
申请日：2005-10-03
申请人： AMGEN INC.
发明人： PATEL, Vinod F. , KIM, Joseph L. , GEUNS-MEYER, Stephanie D. , CHAFFEE, Stuart C. , CEE, Victor J. , HODOUS, Brian L. , BELLON, Steven , HARMANGE, Jean-christophe , OLIVIERI, Philip R. , THAMAN, Maya C. , DIMAURO, Erin F. , BUCHANAN, John L. , MCGOWAN, David C. , ALBRECHT, Brian K. , DEAK, Holly L. , BEMIS, Jean E. , WHITE, Ryan , MARTIN, Matthew W. , HABGOOD, Gregory J. , MASSE, Craig E. , BUCKNER, William H. , TEMPEST, Paul A. , HERBERICH, Bradley J. , GRACEFFA, Russell , ZHANG, Dawei , XU, Shimin , SHAM, Kelvin , RZASA, Robert M. , FALSEY, James Richard , CHAKRABARTI, Partha P. , CAO, Guo-giang , TOMLINSON, Susan Ann , PETTUS, Liping H. , SMITH, Adrian Leonard , PARAS, Nick A. , LIU, Gang , DEMORIN, Frenel F. , TASKER, Andrew , REED, Anthony
IPC分类号： C07D239/84
CPC分类号： C07D215/38 , C07C205/37 , C07D215/12 , C07D217/12 , C07D217/22 , C07D217/26 , C07D239/26 , C07D239/84 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I, wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
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