-
公开(公告)号：EP1802586B1
公开(公告)日：2013-04-24
申请号：EP05812237.5
申请日：2005-10-17
申请人： Amgen Inc.
发明人： CHAFFEE, Stuart C. , ALBRECHT, Brian K. , HODOUS, Brian L. , MARTIN, Matthew W. , MCGOWAN, David C. , DIMAURO, Erin F. , REDDY, Gade , CEE, Victor J. , OLIVIERI, Philip R. , REED, Anthony , ROMERO, Karina
IPC分类号： C07D239/42 , A61K31/505 , A61P35/00
CPC分类号： C07D213/74 , C07D213/81 , C07D215/14 , C07D239/42 , C07D241/42 , C07D401/06 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/06 , C07D413/12 , C07D417/12 , C07D471/04
-
公开(公告)号：EP1836174B2
公开(公告)日：2019-10-02
申请号：EP05818381.5
申请日：2005-10-03
申请人： AMGEN INC.
发明人： PATEL, Vinod F. , KIM, Joseph L. , GEUNS-MEYER, Stephanie D. , CHAFFEE, Stuart C. , CEE, Victor J. , HODOUS, Brian L. , BELLON, Steven , HARMANGE, Jean-christophe , OLIVIERI, Philip R. , THAMAN, Maya C. , DIMAURO, Erin F. , BUCHANAN, John L. , MCGOWAN, David C. , ALBRECHT, Brian K. , DEAK, Holly L. , BEMIS, Jean E. , WHITE, Ryan , MARTIN, Matthew W. , HABGOOD, Gregory J. , MASSE, Craig E. , BUCKNER, William H. , TEMPEST, Paul A. , HERBERICH, Bradley J. , GRACEFFA, Russell , ZHANG, Dawei , XU, Shimin , SHAM, Kelvin , RZASA, Robert M. , FALSEY, James Richard , CHAKRABARTI, Partha P. , CAO, Guo-giang , TOMLINSON, Susan Ann , PETTUS, Liping H. , SMITH, Adrian Leonard , PARAS, Nick A. , LIU, Gang , DEMORIN, Frenel F. , TASKER, Andrew , REED, Anthony
IPC分类号： C07D239/84
-
3.发明授权6-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YLMETHYL)-1,6-NAPHTHYRIDIN-5(6H)-ONE DERIVATIVES AS C-MET INHIBITORS 有权6 - （[1,2,4]三唑并[4,3-A]吡啶-3-基甲基）-1,6-萘啶-5（6H） - 酮衍生物作为C-Met抑制剂
公开(公告)号：EP2231663B1
公开(公告)日：2017-08-02
申请号：EP08870985.2
申请日：2008-10-14
申请人： Amgen Inc.
发明人： ALBRECHT, Brian K. , BAUER, David , BELLON, Steven , BODE, Christiane M. , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Derin , HARMANGE, Jean-Christophe , HIRAI, Satoko , HUNGATE, Randall W. , KIM, Tae-Seong , LEWIS, Richard T. , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark H. , POTASHMAN, Michelle , SIEGMUND, Aaron C. , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin , PETERSON, Emily, A. , ROMERO, Karina , COPELAND, Katrina, W.
IPC分类号： C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , A61K31/4355
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
-
4.发明公开
公开(公告)号：EP2231663A2
公开(公告)日：2010-09-29
申请号：EP08870985.2
申请日：2008-10-14
申请人： Amgen, Inc
发明人： ALBRECHT, Brian K. , BAUER, David , BELLON, Steven , BODE, Christiane M. , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Derin , HARMANGE, Jean-christophe , HIRAI, Satoko , HUNGATE, Randall W. , KIM, Tae-seong , LEWIS, Richard T. , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark H. , POTASHMAN, Michelle , SIEGMUND, Aaron C. , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin , PETERSON, Emily, A. , ROMERO, Karina , COPELAND, Katrina, W.
IPC分类号： C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , A61K31/4355
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 选定的化合物对于预防和治疗疾病如HGF介导的疾病是有效的。 本发明包括新化合物，类似物，前药和药学上可接受的盐，用于预防和治疗涉及癌症等的疾病和其他疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及用于这些方法的中间体。
-
5.发明公开ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS 有权ARYLNITROGENHALTIGE双环化合物及其作为激酶抑制剂
公开(公告)号：EP1836174A2
公开(公告)日：2007-09-26
申请号：EP05818381.5
申请日：2005-10-03
申请人： AMGEN INC.
发明人： PATEL, Vinod F. , KIM, Joseph L. , GEUNS-MEYER, Stephanie D. , CHAFFEE, Stuart C. , CEE, Victor J. , HODOUS, Brian L. , BELLON, Steven , HARMANGE, Jean-christophe , OLIVIERI, Philip R. , THAMAN, Maya C. , DIMAURO, Erin F. , BUCHANAN, John L. , MCGOWAN, David C. , ALBRECHT, Brian K. , DEAK, Holly L. , BEMIS, Jean E. , WHITE, Ryan , MARTIN, Matthew W. , HABGOOD, Gregory J. , MASSE, Craig E. , BUCKNER, William H. , TEMPEST, Paul A. , HERBERICH, Bradley J. , GRACEFFA, Russell , ZHANG, Dawei , XU, Shimin , SHAM, Kelvin , RZASA, Robert M. , FALSEY, James Richard , CHAKRABARTI, Partha P. , CAO, Guo-giang , TOMLINSON, Susan Ann , PETTUS, Liping H. , SMITH, Adrian Leonard , PARAS, Nick A. , LIU, Gang , DEMORIN, Frenel F. , TASKER, Andrew , REED, Anthony
IPC分类号： C07D239/84
CPC分类号： C07D215/38 , C07C205/37 , C07D215/12 , C07D217/12 , C07D217/22 , C07D217/26 , C07D239/26 , C07D239/84 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I, wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
-
6.发明授权ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS 有权ARYLNITROGENHALTIGE双环化合物及其作为激酶抑制剂
公开(公告)号：EP1836174B1
公开(公告)日：2013-02-27
申请号：EP05818381.5
申请日：2005-10-03
申请人： AMGEN INC.
发明人： PATEL, Vinod F. , KIM, Joseph L. , GEUNS-MEYER, Stephanie D. , CHAFFEE, Stuart C. , CEE, Victor J. , HODOUS, Brian L. , BELLON, Steven , HARMANGE, Jean-christophe , OLIVIERI, Philip R. , THAMAN, Maya C. , DIMAURO, Erin F. , BUCHANAN, John L. , MCGOWAN, David C. , ALBRECHT, Brian K. , DEAK, Holly L. , BEMIS, Jean E. , WHITE, Ryan , MARTIN, Matthew W. , HABGOOD, Gregory J. , MASSE, Craig E. , BUCKNER, William H. , TEMPEST, Paul A. , HERBERICH, Bradley J. , GRACEFFA, Russell , ZHANG, Dawei , XU, Shimin , SHAM, Kelvin , RZASA, Robert M. , FALSEY, James Richard , CHAKRABARTI, Partha P. , CAO, Guo-giang , TOMLINSON, Susan Ann , PETTUS, Liping H. , SMITH, Adrian Leonard , PARAS, Nick A. , LIU, Gang , DEMORIN, Frenel F. , TASKER, Andrew , REED, Anthony
IPC分类号： C07D239/84
CPC分类号： C07D215/38 , C07C205/37 , C07D215/12 , C07D217/12 , C07D217/22 , C07D217/26 , C07D239/26 , C07D239/84 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A 1 , A 2 , A 3 , B, R 1 , R 2 , R 3 and R 4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
-
公开(公告)号：EP1963312A1
公开(公告)日：2008-09-03
申请号：EP06838016.1
申请日：2006-11-17
申请人： Amgen Inc.
发明人： XUE, Qiufen , ALBRECHT, Brian K. , ANDERSEN, Denise Lyn , BARTBERGER, Michael , BROWN, James , BROWN, Ryan , CHAFFEE, Stuart C. , CHENG, Yuan , CROGHAN, Michael , GRACEFFA, Russell , HARRIED, Scott , HITCHCOCK, Stephen , HUNGATE, Randall , JUDD, Ted , KALLER, Matthew , KREIMAN, Charles , LA, Daniel , LOPEZ, Patricia , MASSE, Craig E. , MONENSCHEIN, Holger , NGUYEN, Thomas , NIXEY, Thomas , PATEL, Vinod F. , PENNINGTON, Lewis , WEISS, Matthew , YANG, Bryant , ZHONG, Wenge
IPC分类号： C07D405/12 , C07D413/12 , A61K31/44 , A61P25/28
CPC分类号： C07D405/12 , C07D413/12
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I) wherein R1, W, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula (I), or compositions including them, to a subject. The invention also comprises further embodiments of Formulas (II) and (III), intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译： 本发明包括用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD）和相关病症）的一类新化合物。 在一个实施方案中，所述化合物具有通式（I）其中R 1，W，B，R 3，R 4，R 5，i和j如本文所定义。 本发明还包括药物组合物，其包含一种或多种式（I）化合物，用于这些化合物的方法，包括治疗AD和相关疾病，通过施用式（I）化合物或包含它们的组合物， 到一个主题。 本发明还包括式（II）和（III）的其他实施方案，可用于制备本发明化合物的中间体和方法。
-
公开(公告)号：EP1802586A2
公开(公告)日：2007-07-04
申请号：EP05812237.5
申请日：2005-10-17
申请人： Amgen Inc.
发明人： CHAFFEE, Stuart C. , ALBRECHT, Brian K. , HODOUS, Brian L. , MARTIN, Matthew W. , MCGOWAN, David C. , DIMAURO, Erin F. , REDDY, Gade , CEE, Victor J. , OLIVIERI, Philip R. , REED, Anthony , ROMERO, Karina
IPC分类号： C07D239/42 , A61K31/505 , A61P35/00
CPC分类号： C07D213/74 , C07D213/81 , C07D215/14 , C07D239/42 , C07D241/42 , C07D401/06 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I: wherein A1, A2, A3, A4, R1 and R2 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
-
公开(公告)号：EP1963312B1
公开(公告)日：2014-07-02
申请号：EP06838016.1
申请日：2006-11-17
申请人： Amgen Inc.
发明人： XUE, Qiufen , ALBRECHT, Brian K. , ANDERSEN, Denise Lyn , BARTBERGER, Michael , BROWN, James , BROWN, Ryan , CHAFFEE, Stuart C. , CHENG, Yuan , CROGHAN, Michael , GRACEFFA, Russell , HARRIED, Scott , HITCHCOCK, Stephen , HUNGATE, Randall , JUDD, Ted , KALLER, Matthew , KREIMAN, Charles , LA, Daniel , LOPEZ, Patricia , MASSE, Craig E. , MONENSCHEIN, Holger , NGUYEN, Thomas , NIXEY, Thomas , PATEL, Vinod F. , PENNINGTON, Lewis , WEISS, Matthew , YANG, Bryant , ZHONG, Wenge
IPC分类号： C07D405/12 , C07D413/12 , A61K31/44 , A61P25/28
CPC分类号： C07D405/12 , C07D413/12
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.057 秒)
