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    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    5.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
    方法和组合物诊断和预后肾损伤和肾功能衰竭的

    公开(公告)号：EP2585825A4

    公开(公告)日：2013-12-11

    申请号：EP11798514

    申请日：2011-06-23

    申请人： ASTUTE MEDICAL INC

    发明人： ANDERBERG JOSEPH ,  GRAY JEFF ,  MCPHERSON PAUL ,  NAKAMURA KEVIN ,  KAMPF JAMES PATRICK

    IPC分类号： G01N33/48 ,  G01N33/53 ,  G01N33/68

    CPC分类号： G01N33/6893 ,  G01N33/573 ,  G01N33/74 ,  G01N33/92 ,  G01N2800/347 ,  G01N2800/60

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect Insulin-like growth factor-binding protein 4, and optionally further a kidney injury marker of Tumor necrosis factor receptor superfamily member 8, Alpha-Fetoprotein, Thyroxine-binding globulin, Prostate-specific antigen (free form), Apolipoprotein A, Apolipoprotein E, Thyrotropin subunit beta, Platelet-derived growth factor B/B dimer, C-C motif chemokine 7, C-C motif chemokine 26, Complement C4-B, Corticotropin, Interferon alpha-2, Interleukin-4 receptor alpha chain, , Insulin-like growth factor-binding protein 5, Interleukin 21, Interleukin 23 alpha subunit, Interleukin-28A, Interleukin-33, Lutropin subunit beta, Matrix Metalloproteinase-1, Neural cell adhesion molecule 1, Pigment epithelium-derived factor, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 3, and IgG4 as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及一种用于在患有或疑似患有肾损伤的受试者监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用被配置为检测选自肿瘤坏死因子受体超家族成员8，甲胎蛋白，甲状腺素结合球蛋白，前列腺特异性抗原中选择的肾损伤标记物的一个或多个测定（自由 ），载脂蛋白A载脂蛋白E，促甲状腺素亚基β，血小板衍生生长因子B / B二聚体，CC趋化因子基序7，CC趋化因子基序26补体C4-B，促肾上腺皮质激素，干扰素α-2，白介素-4受体α链， 胰岛素样生长因子结合蛋白4，胰岛素样生长因子结合蛋白5，白介素21，白介素23α亚基，白细胞介素28A，白细胞介素33，促黄体素β亚基，基质金属蛋白酶1，神经细胞粘附分子1 ，色素上皮衍生因子，血管内皮生长因子受体2，血管内皮生长因子受体3和IgG4作为肾损伤的诊断和预后的生物标志物。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    9.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
    方法和组合物诊断和预后判断肾功能衰竭和肾损害

    公开(公告)号：EP2946211A4

    公开(公告)日：2016-11-02

    申请号：EP14740960

    申请日：2014-01-16

    申请人： ASTUTE MEDICAL INC

    发明人： ANDERBERG JOSEPH ,  GRAY JEFF ,  MCPHERSON PAUL ,  NAKAMURA KEVIN ,  KAMPF JAMES PATRICK

    IPC分类号： G01N33/566 ,  C12M1/34 ,  C40B30/04 ,  C40B60/12 ,  G01N33/573

    CPC分类号： G01N33/6893 ,  G01N33/70 ,  G01N2333/4703 ,  G01N2333/4745 ,  G01N2333/65 ,  G01N2333/8146 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56 ,  G06F19/24 ,  G16H50/20 ,  Y02A90/26

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a measured urine concentration of one or more of TIMP2 and IGFBP7 in combination with one or more of a measured serum creatinine and a measured urine output, which results are correlated to the renal status of the subject, and can be used for diagnosis, prognosis, risk stratification, staging, monitoring, categorizing and determination of further diagnosis and treatment regimens in subjects suffering or at risk of suffering from an injury to renal function, reduced renal function, and/or acute renal failure.

    摘要翻译： 本发明涉及一种用于在患有或疑似患有肾损伤的受试者监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用一个或多个与一个或多个测量的血清肌酸酐和测量的尿量，所述结果关联于受试者的肾状态的TIMP2和IGFBP7在组合中的测量尿液浓度，和 可以的受试者或在从损伤患肾功能的风险可用于诊断，预后，风险分层，分期，监测，分类和确定进一步的诊断和治疗方案，肾功能降低和/或急性肾衰竭。