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1.发明公开
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公开(公告)号：EP0627933A4
公开(公告)日：1997-01-15
申请号：EP93907044
申请日：1993-02-25
申请人： AUTOIMMUNE INC
IPC分类号： A61K38/22 , A61K38/00 , A61K38/11 , A61K38/17 , A61K38/26 , A61K38/28 , A61K38/39 , A61K39/00 , A61P3/08 , A61P3/10 , A61P27/02 , A61P29/00 , A61P37/00 , C07K14/47 , A61K37/02 , A61K37/12 , A61K37/24 , C07K3/00
CPC分类号： A61K38/1709 , A61K38/26 , A61K38/28 , A61K38/39 , A61K39/0008 , C07K14/4713
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3.发明公开SUPPRESSION OF T-CELL PROLIFERATION USING PEPTIDE FRAGMENTS OF MYELIN BASIC PROTEIN. 失效T细胞增殖的肽段髓鞘碱性蛋白的抑制。
公开(公告)号：EP0650498A4
公开(公告)日：1995-06-21
申请号：EP93912176
申请日：1993-04-09
申请人： AUTOIMMUNE INC
IPC分类号： A61K38/00 , A61K38/11 , A61K38/39 , A61K39/00 , A61P37/00 , A61P37/02 , C07K7/08 , C07K14/435 , C07K14/47
CPC分类号： A61K38/39 , A61K39/0008 , C07K14/4713
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4.发明公开TREATMENT OF AUTOIMMUNE DISEASE USING TOLERIZATION IN COMBINATION WITH METHOTREXATE 失效联合甲磺酸盐治疗自身免疫性疾病后耐受性增加
公开(公告)号：EP0994717A4
公开(公告)日：2000-07-26
申请号：EP98908452
申请日：1998-01-26
申请人： AUTOIMMUNE INC
IPC分类号： C07D475/08 , A61K31/519 , A61K38/00 , A61K38/17 , A61K38/26 , A61K38/28 , A61K38/39 , A61K38/51 , A61K39/00 , A61P3/10 , A61P19/04 , A61P27/02 , A61P29/00 , A61P37/06 , B41J2/21 , H04N1/60 , A61K31/505 , A61P37/00
CPC分类号： A61K31/519 , A61K39/0008 , A61K2039/542 , B41J2/2107 , G06K2215/0094 , G06K2215/0097
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公开(公告)号：EP0662838A4
公开(公告)日：1996-07-24
申请号：EP93924897
申请日：1993-09-24
申请人： AUTOIMMUNE INC
发明人： WEINER HOWARD L , TRENTHAM DAVID E
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6.发明公开SUPPRESSION OF PROLIFERATIVE RESPONSE AND INDUCTION OF TOLERANCE WITH POLYMORPHIC CLASS II MHC ALLOPEPTIDES. 失效抑制性反应的BOSÄRTIGER和宽容的多晶型TYPE II具体MHC ALLOPEPTIDE感应。
公开(公告)号：EP0637249A4
公开(公告)日：1997-01-08
申请号：EP93910671
申请日：1993-04-20
申请人： AUTOIMMUNE INC
CPC分类号： C07K14/70539 , A61K35/26 , A61K35/28 , A61K38/00 , A61K39/001 , A61K39/395 , A61K2300/00
摘要： Described are methods for: (a) suppressing the ability of T-cells from a mammal to proliferate in response to stimulation by nonself mammalian tissue; and (b) suppressing immune response which leads to allograft rejection in a mammal receiving an allograft from a donor mammal. The methods involve orally administering to the mammal to be thus treated a composition comprising at least one of: (i) a major histocompatibility complex Class II antigen from a second nonself mammal or from tissue of a mammal syngeneic to said nonself mammal; (ii) at least one synthetic peptide corresponding to a T-cell suppressive fragment of said Class II antigen, said composition being administered in an amount effective to suppress said proliferation. The foregoing compositions are also described.
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7.发明公开
公开(公告)号：EP0555413A4
公开(公告)日：1994-12-07
申请号：EP92902860
申请日：1991-10-31
申请人： AUTOIMMUNE INC
IPC分类号： A61K38/00 , A61K20060101 , A61K35/26 , A61K35/28 , A61K39/00 , A61P37/06 , A61K37/00 , A61K37/10
CPC分类号： A61K39/001 , A61K35/26 , A61K35/28
摘要： Disclosed herein are methods for suppressing allograft rejection in mammals comprising administering to a mammal about to undergo or having undergone allograft surgery an agent selected from the group consisting of splenic tissue from an allograft donor, splenic extracts, cultured lymphocytes from an allograft donor, extracts of said cultured lymphocytes, MHC antigens, transplantation rejection suppressive fragments and analogs of MHC antigens in an oral or aerosol form. Also disclosed herein are pharmaceutical formulations and dosage forms for use in said methods.
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8.发明公开ENHANCEMENT OF THE DOWN-REGULATION OF AUTOIMMUNE DISEASES BY ORAL ADMINISTRATION OF AUTOANTIGENS. 失效增加异径自身免疫性疾病的调控汽车抗原口服。
公开(公告)号：EP0594607A4
公开(公告)日：1993-04-20
申请号：EP91906685
申请日：1991-03-04
发明人： WEINER HOWARD L , HAFLER DAVID A , KHOURY SAMIA J
IPC分类号： A61K38/00 , A61K38/11 , A61K38/17 , A61K38/39 , A61K39/00 , A61K39/39 , A61P37/00 , A61K37/20
CPC分类号： A61K39/0008 , A61K38/00 , A61K38/1709 , A61K38/39 , A61K39/0005 , A61K2300/00
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