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1.ENHANCEMENT OF THE DOWN-REGULATION OF AUTOIMMUNE DISEASES BY ORAL ADMINISTRATION OF AUTOANTIGENS. 失效
标题翻译: 增加异径自身免疫性疾病的调控汽车抗原口服。公开(公告)号:EP0594607A4
公开(公告)日:1993-04-20
申请号:EP91906685
申请日:1991-03-04
发明人: WEINER HOWARD L , HAFLER DAVID A , KHOURY SAMIA J
IPC分类号: A61K38/00 , A61K38/11 , A61K38/17 , A61K38/39 , A61K39/00 , A61K39/39 , A61P37/00 , A61K37/20
CPC分类号: A61K39/0008 , A61K38/00 , A61K38/1709 , A61K38/39 , A61K39/0005 , A61K2300/00
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2.TREATMENT OF AUTOIMMUNE DISEASE USING ORAL TOLERIZATION AND/OR TYPE I INTERFERON 失效
标题翻译: 自身免疫性疾病的口服耐受性和/或I型干扰素的治疗公开(公告)号:EP0752880A4
公开(公告)日:2000-08-09
申请号:EP95916183
申请日:1995-04-07
发明人: HAFLER DAVID A , WEINER HOWARD L
IPC分类号: A61K38/00 , A61K38/17 , A61K38/21 , A61K38/26 , A61K38/28 , A61K39/00 , A61P3/08 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P37/00 , A61P43/00 , C07K14/47 , A61K38/39
CPC分类号: C07K14/4713 , A61K38/212 , A61K38/215 , A61K39/0008 , A61K2300/00
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3.TREATMENT OF AUTOIMMUNE DISEASES BY ORAL ADMINISTRATION OF AUTOANTIGENS. 失效
标题翻译: 自身免疫性疾病由AUTO抗原口服给药治疗。公开(公告)号:EP0359783A4
公开(公告)日:1990-06-27
申请号:EP88906457
申请日:1988-06-24
发明人: WEINER HOWARD L , HAFLER DAVID A
IPC分类号: A61K38/00 , A61K38/11 , A61K38/17 , A61K38/39 , A61K39/00 , A61K39/04 , A61P25/00 , A61P29/00 , A61P37/00 , C07K7/08 , C07K14/46 , C07K14/47
CPC分类号: A61K39/04 , A61K38/1709 , A61K38/39 , A61K39/0008 , A61K2039/542 , A61K2039/543 , C07K14/4713
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4.MODULATION OF CYTOKINE PATTERNS OF HUMAN AUTOREACTIVE T-CELL CLONES 失效
标题翻译: MODULIERUNG VON CYTOKIN-MUSTERN VON MENSCHLICHEN T-ZELL KLONEN公开(公告)号:EP0825870A4
公开(公告)日:2002-09-25
申请号:EP96920109
申请日:1996-04-19
发明人: HAFLER DAVID A , WEINER HOWARD L , KUCHROO VIJAY K
CPC分类号: A61K39/0008 , A61K38/00 , C07K14/4713
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5.
公开(公告)号:EP0553291A4
公开(公告)日:1994-11-30
申请号:EP92900084
申请日:1991-10-15
发明人: WEINER HOWARD L , HAFLER DAVID A
CPC分类号: A61K38/39 , A61K38/00 , A61K39/0008 , A61K2039/542 , Y10S514/825
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6.SUPPRESSION OF T-CELL PROLIFERATION USING PEPTIDE FRAGMENTS OF MYELIN BASIC PROTEIN. 失效
标题翻译: T细胞增殖的肽段髓鞘碱性蛋白的抑制。公开(公告)号:EP0650498A4
公开(公告)日:1995-06-21
申请号:EP93912176
申请日:1993-04-09
申请人: AUTOIMMUNE INC
IPC分类号: A61K38/00 , A61K38/11 , A61K38/39 , A61K39/00 , A61P37/00 , A61P37/02 , C07K7/08 , C07K14/435 , C07K14/47
CPC分类号: A61K38/39 , A61K39/0008 , C07K14/4713
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7.
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公开(公告)号:EP0627933A4
公开(公告)日:1997-01-15
申请号:EP93907044
申请日:1993-02-25
申请人: AUTOIMMUNE INC
IPC分类号: A61K38/22 , A61K38/00 , A61K38/11 , A61K38/17 , A61K38/26 , A61K38/28 , A61K38/39 , A61K39/00 , A61P3/08 , A61P3/10 , A61P27/02 , A61P29/00 , A61P37/00 , C07K14/47 , A61K37/02 , A61K37/12 , A61K37/24 , C07K3/00
CPC分类号: A61K38/1709 , A61K38/26 , A61K38/28 , A61K38/39 , A61K39/0008 , C07K14/4713
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9.SUPPRESSION OF PROLIFERATIVE RESPONSE AND INDUCTION OF TOLERANCE WITH POLYMORPHIC CLASS II MHC ALLOPEPTIDES. 失效
标题翻译: 抑制性反应的BOSÄRTIGER和宽容的多晶型TYPE II具体MHC ALLOPEPTIDE感应。公开(公告)号:EP0637249A4
公开(公告)日:1997-01-08
申请号:EP93910671
申请日:1993-04-20
申请人: AUTOIMMUNE INC
CPC分类号: C07K14/70539 , A61K35/26 , A61K35/28 , A61K38/00 , A61K39/001 , A61K39/395 , A61K2300/00
摘要: Described are methods for: (a) suppressing the ability of T-cells from a mammal to proliferate in response to stimulation by nonself mammalian tissue; and (b) suppressing immune response which leads to allograft rejection in a mammal receiving an allograft from a donor mammal. The methods involve orally administering to the mammal to be thus treated a composition comprising at least one of: (i) a major histocompatibility complex Class II antigen from a second nonself mammal or from tissue of a mammal syngeneic to said nonself mammal; (ii) at least one synthetic peptide corresponding to a T-cell suppressive fragment of said Class II antigen, said composition being administered in an amount effective to suppress said proliferation. The foregoing compositions are also described.
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